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Marketing Mix of Company Jiří Plocek
Dosedlová, Petra ; Jareš, Jaromír (referee) ; Mráček, Pavel (advisor)
This bachelor’s thesis is aimed on the optimal design of the marketing mix. Analysis of the current status of the selected company and file a subsequent basis, which should aim to future business growth. The aim of my work is to compare the current factors affecting the operation of the company, and to assess whether there are any ways through which would achieve a better situation of the company on the Czech market.
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Proposal of Marketing Strategy of Schwarzwolf Outdoor Brand
Jaroš, Martin ; Kaderka, Tomáš (referee) ; Chalupský, Vladimír (advisor)
The thesis describes a proposal of iMi Partner, a.s. marketing strategies for entering new markets with Schwarzwolf outdoor brand. The proposal section contains a summary measure for the achievement of expanding the product into new markets and for strengthening the brand. The proposed section is preceded by a strategic analysis of external and internal environment of the company. Part of this work is devoted to the marketing as its theoretical starting point.
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Polymeric nanoparticles for poorly water soluble drugs delivery
Nekolová, Martina ; Holas, Ondřej (advisor) ; Smékalová, Monika (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Mentor: PharmDr. Ondřej Holas, Ph.D. Student: Martina Nekolová Title of thesis: Polymeric nanoparticles for poorly water-soluble drugs delivery Polymeric nanoparticles represent a modern drug form. One of the main advantages is influencing the pharmacokinetic properties of the administered substance - e.g. increasing solubility in water. They enable the targeted delivery of the drug to the affected tissue and this way minimize adverse effects. This could be of great benefit to the therapy of cancer or inflammatory diseases. Both the target tissue and the nanoparticles must have some specific properties. For particles, it is, for example, size and surface charge. The aim of this work was to prepare nanoparticles with a substance poorly soluble in water, represented by curcumin. The particles were prepared by the nanoprecipitation method with different types of poly(lactic-co-glycolic acid) (PLGA) copolymer. A 50:50 linear PLGA polymer and a branched PLGA A2 polymer were used. The prepared nanoparticles were compared on several parameters - particle size and polydispersity, encapsulation efficiency (EE), drug-loading capacity (DLC) and dissolution profile. PLGA 50:50 was found to provide...
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Preparation and evaluation of nanoparticles for targeted treatment of inflammatory diseases
Wurzel, Natalie ; Holas, Ondřej (advisor) ; Smékalová, Monika (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Supervisor: PharmDr. Ondřej Holas, PhD Consultant: Mgr. Barbora Boltnarová Student: Natalie Wurzel Title of Thesis: Preparation and evaluation of nanoparticles for targeted treatment of inflammatory diseases Nanoparticles are used in the health sciences for, among other things, targeted drug delivery. This is used for the therapy of cancer and chronic inflammatory diseases. The aim of this diploma thesis was to prepare nanoparticles suitable for targeted treatment of inflammatory diseases. The task was to determine the ideal concentration of the active substance, which would ensure high encapsulation efficiency and drug loading. The difference between nanoparticles prepared from PLGA 5/5E and PLGA 7/3A was also investigated. Nanoparticles were prepared by the nanoprecipitation method. The matrix of the nanoparticles was composed of PLGA with different ratios of lactic acid and glycolic acid. Acetone was used as the organic solvent. The encapsulated active substance was the anti-inflammatory dexamethasone acetate. The aqueous phase was consisted of a 0.1% aqueous solution of Pluronic F-127. The evaluated parameters of the resulting nanoparticles included size, polydispersity index, zeta potential,...
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Polymeric nanoparticles: platform for poorly water soluble drugs delivery
Roztočilová, Adéla ; Holas, Ondřej (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Mentor: PharmDr. Ondřej Holas, Ph.D. Student: Adéla Roztočilová Title of thesis: Polymeric nanoparticles as a platform for delivery of poorly water-soluble drugs Polymer nanoparticles can be used as drug carriers due to their beneficial properties. One of the advantages of polymeric nanoparticles is, for example, to increase the solubility of drugs in water. They have great potential in the therapy of inflammatory diseases such as Crohn's disease or in shifting cancer pharmacotherapy. The main objective of this thesis was to prepare polymeric nanoparticles with encapsulated curcumin as model active ingredient. Four types of poly(lactic-co-glycolic acid) (PLGA) copolymer were used to prepare the nanoparticles. Nanoprecipitation and emulsion evaporation methods were employed. The parameters evaluated were encapsulation efficiency, drug loading, particle size and polydispersity. Both the water phase, where two different surfactants were employed, and the organic phase were varied during the experiment. The experimental part also used a dissociation method where two types of PLGA copolymer were compared and during the dissociation, samples were taken at predetermined times to determine the total...
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Targeting and positioning in a presidential election campaign of Petr Pavel - young voters generation
Dejmková, Tereza ; Konrádová, Marcela (advisor) ; Shavit, Anna (referee)
This bachelor thesis deals with targeting and positioning of the presidential election campaign of Petr Pavel and focuses mainly on addressing the youngest generation of voters, Generation Z. The 2023 presidential election was different in several ways, but one of them was, for example, the targeting of some candidates to Generation Z. The generation currently includes the majority of voters who participated in the presidential election for the first time, and who may also have followed it more closely for the first time. The aim of this thesis is therefore to find out to what extent the targeting and positioning of the campaign was adapted to Generation Z in the development of the strategy, and also to find out whether Petr Pavel was able to reach this target group through the campaign and through which steps he achieved this. The theoretical part of the thesis first describes and defines the tools of political marketing, characterizes Generation Z and the specifics of their voting behaviour. In the practical part of the thesis, the aforementioned tools of political marketing are applied to the campaign of Petr Pavel. The information for this part of the thesis was obtained from a personal interview with the marketing director of the Petr Pavel campaign, Martin Klčo, conducted by the author of the...
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Crypto.com Marketing Case Study Wiithin Major Sport Events
Kamiš, Kilián ; Ortová, Nina (advisor) ; Koblovský, Petr (referee)
The bachelor thesis examines marketing and communication outcomes of the cryptocurrency exchange Crypto.com at major sporting events between the years 2021 and 2022. Since the issue of cryptocurrencies and blockchain is not generally known at present, the theoretical part of the thesis is devoted to this topic. In the initial three chapters, I present, according to the market capitalization parameter, the main cryptocurrencies that Crypto.com has in its portfolio. Part of the excursion into the world of virtual currencies is also an insight into the nature of the blockchain and its potential use in marketing. The practical part is represented by a content study that analyzes media and sponsorship partnerships between Crypto.com and brands in the field of professional sports. Individual fragments are analyzed primarily in connection with Morning Consult's research, which examined the relationship of sports fans with cryptocurrencies and blockchain. In the second part of the research, the advertising outputs of the 2022 Super Bowl cryptocurrency exchange competitors and their impact on the current competitive market position are described. The thesis concludes with suggestions and findings that arise from the stated research questions.
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Proposal of the Strategy of the Selected Company to Enter French Market
Michalová, Martina ; Ulč, Jakub (referee) ; Chlebovský, Vít (advisor)
The master´s thesis is focused on the determination of individual analyzes of the environment and the competitive positioning of the company. It also specifies terms such as marketing goals, segmentation and targeting. The last part of the theoretical basis is dedicated to the company´s expansion into the foreign market, as well as individual methods of entry. The analysis of the current state is focused on the practical use of theoretical knowledge and their actual implementation in practice. The master´s thesis also includes a specific business strategy for the entry of the selected company into the French market, processed in the form of a marketing plan, as a proposal in response to the results of individual analyzes carried out.
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Polymeric nanoparticles for poorly water soluble drugs delivery
Nekolová, Martina ; Holas, Ondřej (advisor) ; Smékalová, Monika (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Mentor: PharmDr. Ondřej Holas, Ph.D. Student: Martina Nekolová Title of thesis: Polymeric nanoparticles for poorly water-soluble drugs delivery Polymeric nanoparticles represent a modern drug form. One of the main advantages is influencing the pharmacokinetic properties of the administered substance - e.g. increasing solubility in water. They enable the targeted delivery of the drug to the affected tissue and this way minimize adverse effects. This could be of great benefit to the therapy of cancer or inflammatory diseases. Both the target tissue and the nanoparticles must have some specific properties. For particles, it is, for example, size and surface charge. The aim of this work was to prepare nanoparticles with a substance poorly soluble in water, represented by curcumin. The particles were prepared by the nanoprecipitation method with different types of poly(lactic-co-glycolic acid) (PLGA) copolymer. A 50:50 linear PLGA polymer and a branched PLGA A2 polymer were used. The prepared nanoparticles were compared on several parameters - particle size and polydispersity, encapsulation efficiency (EE), drug-loading capacity (DLC) and dissolution profile. PLGA 50:50 was found to provide...
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Polymeric particles for targeted drug delivery into mononuclear phagocytic system
Prošková, Denisa ; Holas, Ondřej (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Supervisor: PharmDr. Ondřej Holas, Ph.D. Consultant: Dmytro Iefremenko, M.Sc. Student: Denisa Prošková Title of Thesis: Polymeric paticles for targeted drug delivery into mononuclear fagocytic system Polymeric nanoparticles (NPs) can act as drug nanocarriers. They are frequently used to enhance distribution to a target tissues in which they specifically act. The mononuclear phagocytic system (MPS) represents a target to which NPs could be specifically distributed. It has been found that cells of this system are involved in the development of a number of diseases. Optimal parameters of NPs suitable for MPS targeting are size ranging between 100 nm and 300 nm and negative surface charge. In this work the polymeric nanoparticles with encapsulated cholic acid were prepared by nanoprecipitation method using five selected types of non-ionic surfactants in concentration of 0,1%, 0,5%, 1% and 2%. PLGA was the polymer used for their preparation because of its high biocompatibility and biodegradability. Encapsulation efficiency, size and zeta-potential were selected as critical parameters chosen for prepared nanoparticles. The obtained data were used to characterize the effect of non-ionic surfactants on the...
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