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Solutions of the electronic leaflet for the pharmaceutical industry
Psota, Tomáš ; Odstrčilík, Jan (referee) ; Čmiel, Vratislav (advisor)
This bachelor thesis deals with the introduction of electronic package leaflet for drug boxes. The theoretical part deals with the process of registration and production of medicinal products and their modern labeling used for identification. The practical part deals with the issue of printing labels using a web application, so that printed labels comply with the regulations and directives that are given and have not been violated.
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Nowadays....
Kouba, Tomáš ; Surůvka, Jiří (referee) ; Ruller, Tomáš (advisor)
The set of works created from private video of materials, unfinished concepts and new videos. Essential motive passing through these videos is to develop a simple, stern, radical expression.
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Drug transport using microbubbles
Piňos, Ondřej ; Tancjurová, Jana (referee) ; Rudolf, Pavel (advisor)
This bachelor thesis deals with the research in field of medical usage of microbubbles, specially focused on ultrasound iniciated cavitation of microbubbles filled with drugs. Thesis includes technology of manufacturing, chemical composition, efects of cavitated microbubbles on tissue and description of mechanism that occurs during the aplication of ultrasound triggered microbubbles. Second part deals with mathematical description of microbubble under acustic pressure using the Rayleigh-Plesset equation and equation for microbubble with membrane are presented. The MATLAB script for calculation of physical parameters describing state of microbubble is also explained.
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Controlled Drug Release from Biodegradable Hydrogels.
Oborná, Jana ; Chýlková, Jaromíra (referee) ; Kráčmar, Stanislav (referee) ; Kučerík, Jiří (referee) ; Vávrová, Milada (advisor)
This dissertation is focused on the controlled release of drugs from a biodegradable amphiphilic hydrogel based on hydrophobic poly(lactic acid), poly(glycolic acid) and hydrophilic poly(ethylene glycol) (PLGA-PEG-PLGA, ABA) and its modification with itaconic anhydride (ITA). The resulting ,-itaconyl(PLGA-PEG-PLGA) copolymer is referred to as ITA/PLGA-PEG-PLGA/ITA or ITA/ABA/ITA. Itaconic acid provides reactive double bonds and a functional carboxyl group at the ends of the PLGA-PEG-PLGA copolymer chain, thereby rendering the modified ITA/ABA/ITA copolymer less hydrophobic and offering the possibility of forming a carrier for hydrophilic drug substances. These functional copolymers are thermosensitive and change in the external environment (e.g. temperature) causes a sol-gel phase transition due to the formation of micellar structure. The bioactive substances can thus be mixed with a copolymer which is in a low viscous phase (sol phase) and subsequently the mixture can be injected into patient's body at the target site where it forms a gel at 37 °C. This hydrogel becomes a drug depot, which gradually releases the active substance. Prediction of the substance’s release profile from the hydrogel is an effective tool to determine the frequency of administration, potentially enhancing efficacy, and assessment of side effects associated with dosing. The analgesic paracetamol and the sulfonamide antibiotic sulfathiazole were used as model drugs, representing hydrophilic and hydrophobic substances, respectively. The active substances had a significant effect on the resulting hydrogel stiffness. Type of solvent, incubation medium and nanohydroxyapatite also influenced on the gel stiffness and subsequent stability of the hydrogel-drug system. Controlled release of drugs took place in simulated conditions of the human body. Verification of Korsmeyer-Peppas (KP) drug-release model is also discussed in this thesis. The KP model was found suitable for simulating the release of sulfathiazole from ABA and ITA/ABA/ITA hydrogels. On the contrary, the performance of KP model was not suitable for describing the release of paracetamol from the ABA hydrogels. Therefore, a new regression model suitable for both buffered simulated media and water has been proposed. The proposed model fitted better the release of both sulfathiazole and paracetamol from composite material prepared from ABA hydrogel and nanohydroxyapatite.
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Meat, Bones, Useless Things
Walter, František ; Zet, Martin (referee) ; Ruller, Tomáš (advisor)
This work is the presentation of a personal philosophy. Form of video addresses the issues of themes: love, addiction, future, suicide, transience. It is processed with a digital camera in full HD format. I offer no solutions to problems, I displaying only subjective reality.
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Interactions of pharmaceuticals with humic acids
Libiger, Jan ; Enev, Vojtěch (referee) ; Klučáková, Martina (advisor)
The bachelor thesis is focused on interaction of drugs with humic substances, which are part of organic soil matter. The results would help in understanding the behavior of drugs in soil and other natural systems. Three drugs were selected. Humic acid was selected as a sorbent, which was extracted from lignin, the lower one is assumed to be the same as that in organic soil. Based on a comparison of the measurement results using the UV-VIS method, it was determined how much the acid of the given drug is able to absorb and how much it is released back into the water. The theoretical part deals with the information about soil organic matter, with the information about humic substances, with the information about drugs such as ibuprofen, sulfamethoxazol or sulfapyridine. Furthermore, the theoretical part deals with methods of analysis.
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Embedded Control Unit for Instrumentation of Laboratory Appliance
Voda, Zbyšek ; Strnadel, Josef (referee) ; Šimek, Václav (advisor)
Aim of this thesis is modular design of control system for Golem device, which is used for drug research. Several modules with specified controlled area were designed. They communicate using CAN bus and are controlled by Raspberry Pi computer. The thesis includes PCB design and control firmware for modules, backend application for Raspberry Pi, which provides application interface, and simple protocol used for communication between modules. Designed system was tested in simulated environment.
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Determination of antibiotics in the soil ecosystem
Brož, Tomáš ; Zlámalová Gargošová, Helena (referee) ; Mravcová, Ludmila (advisor)
This work deals with a current issue of increasing drug concentrations and thus the growing number of resistant bacteria in the soil. One of the problem helping this issue is the fertilization of agricultural fields with animal faeces, in which antibiotics occur in an unchanged and still active form, as well as the insufficient effectiveness of conventional methods used in wastewater treatment plants. In an effort to improve the monitoring of this problem, a method for the determination of these antibacterial agents in the soil matrix, using solid phase extraction, and also a UPLC/MS method for their evaluation have been developed and optimized. From the group of sulfonamide antibiotics, sulfacetamide, sulfadiazole, sulfamerazine, sulfamethazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfathiaosal and trimethoprim were selected. The lowest limit of detection for the method is 0.3 µg/g for sulfathiazole and the highest of 8.1 µg/g for sulfasalazine. The highest average yields were achieved with sulfamethoxazole, namely 63 ±8 %.
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Shedding Light on The Dark Web
Horváth, Jakub ; Jašková, Jana (referee) ; Ellederová, Eva (advisor)
Tato bakalářská práce pojednává o Temném webu a jeho využití. Přestože je Temný web součástí Internetu takřka od samotného vzniku Internetu, veřejnost mu začala věnovat svou pozornost teprve před pár lety. Hlavním cílem této práce je zvýšit povědomí uživatelů internetu o dané problematice Temného webu a tím jim pomoci chránit sebe a své osobní informace. Práce se zabývá vrstvami, do kterých je web rozdělen a jeho původem. Dále také vysvětluje, jak k Dark Webu získat přístup za použití prohlížeče Tor, popisuje kryptoměnu Bitcoin a tržiště Silkroad. Na závěr práce uvádí obsah, který lze na Dark Webu nalézt, definuje pojem počítačová kriminalita a předpovídá budoucnost Dark Webu.
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Mobile Application for Recording of Compulsive Behavior
Foltýn, Martin ; Janoušek, Vladimír (referee) ; Hrubý, Martin (advisor)
The main goal of this bachelor thesis is to design, implement and test mobile application for iOS platform. It will be used to monitor drug and psychical addiction. The app can help the user to see his progress over time, patterns and triggers of its addictive behavior and guide him to the right direction towards abstinence. It is here to understand the user's problems, motivate and give a helping hand. Important aspects in the development were the study of programming of mobile applications, existing solutions, research of the target group of users, theory of addictology and therapy, design and implementation with understandable user interface, testing of results on real users.
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