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The effect of flubendazole on temozolomide treatment in glioblastoma cells
Dvořáková, Kateřina ; Skálová, Lenka (advisor) ; Pávek, Petr (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Kateřina Dvořáková Supervisor: prof. RNDr. Lenka Skálová, Ph.D. Title of diploma thesis: The effect of flubendazole on temozolomide treatment in glioblastoma cells Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors in adults. Despite significant advances in treatment, GBM remains to have very poor prognosis and median survival of only 12 to 15 months after diagnosis. Standard treatment consists of maximal possible surgical resection followed by chemo-radiotherapy with antitumor drug temozolomide (TMZ), which use is problematic due to fast developing chemoresistance. The aim of this study was to examine the effect of potential anticancer drug, anthelmintic flubendazole (FLU) and effect of FLU in combination with TMZ on GBM cells. For this purpose, two GBM cell lines were used - A172 and T98G. In general FLU reduced cell proliferation more, especially in T98G cells. Moreover, the use of different combinations of TMZ + FLU showed even higher inhibitory effect on the viability of GBM cell lines. The combination of TMZ + FLU reduced the protein level of -tubulin and III-tubulin, simoultaneously interesting changes in STAT3 and EGFR expression, as well as lower...
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Education at the Time of Family Crisis
Dvořáková, Kateřina ; Strouhal, Martin (advisor) ; Krykorková, Hana (referee)
Anotation: The aim of the work is to look into the relationship between education and family crisis. The first part is concerned with the issue of education. It specifies the definition of education, the connections between upbringing and education, also it describes the effects of diverse educational styles in child development and their consequent behaviour and actions in society. The influence of social environment on the individual is not omitted. The second part is focused on studying educational significance of family. The work describes the historical development of family and makes an attempt to identify the origins of crisis that is much discussed topic today. It is trying to capture the influence of family on the education for future generation.
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The Importance of Cooperation between the Clinical Speech Therapist and an Occupational Therapist in People with Disabled Phatic Functions
Dvořáková, Kateřina ; Stančáková, Zuzana (advisor) ; Svěcená, Kateřina (referee)
The main idea of rehabilitation is a multidisciplinary team collaboration. In my bachelor thesis I tried to highlight the team work of the clinical speech therapist and an occupational therapist in people with language disorders. The main objective was to determine how clo-sely these two professionals work and what is important for a person with aphasia. The re-search within the practical part was carry out by a questionnaire that I sent to clinical spe-ech therapists and occupational therapists in various workplaces. Respondents to the ques-tionnaire often mentioned that the work of speech therapist and occupational therapist blends in some situations. However, it does not mean, they do the same tasks. Both disci-pline look at the issue from their own angle, thus ensuring comprehensive care. The result of quantitative research clearly show the fact that in people with impaired communication is cooperation speech therapist and an occupational therapist beneficial, but in many cases is not the ideal level. The end of the thesis highlights the importance of teamwork.
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Adolescents as offenders of crime, the importance of family environment and relationships, the possibility of work with family context
Dvořáková, Kateřina ; Boukalová, Hedvika (advisor) ; Gillernová, Ilona (referee)
DVOŘÁKOVÁ, Kateřina. Adolescents as offenders of crime, the importance of family environment and relationships, the possibility of work with family context. Prague: The Faculty of Arts of Charles University, 2013. 82 pgs. The final thesis. This thesis deals with adolescent as offenders and their family environment and family relationships. The theoretical part of this work presents the importance of the family during adolescence as it related to specific factors which may have an impact on whether juveniles commit the offence or not. The importance of the family environment was the basis for the design, development and implementation of psychosocial program "Together". In the case of juveniles' committing crimes, the relationships between family members are even more at risk, which appears to be at risk for further development and upbringing. The aim of the program was to strengthen the juvenile's personality and relationships in their family. The purpose of the program activities, within a safe environment to allow juvenile offenders and their parents to share some important information from their life experiences to help with reflection. The aim of these activities was also to strengthen the experience of family cohesion that are needed for reciprocal respect and support. The program was...
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The influence of shared custody on the child's school success in primary school
Dvořáková, Kateřina ; Straková, Jana (advisor) ; Valenta, Josef (referee)
The topic of this diploma thesis is the influence of joint custody on school successfulness of a child. In the theoretical part I describe a contemporary family and major functions of the family. I chart the situation of legislation in the Czech Republic, I deal with circumstances how the Czech courts make a decision about commiting children into parental care after a divorce of their parents and whether the number of children being involved in joint custody increases. I am really interested in the fact whether the courts make a decision based on the child needs. Following this part I focus on the definition of school successfulness of children and the behaviour of younger learners. I indicate the factors that could have an influence on school successfulness. In the practical part I present the results of my qualitative research. I explore the influence of joint custody into child school successfulness from the point of view of class teachers. I survey the behaviour of children who live in joint custody after the divorce of parents and I also take an interest into the fact whether the class teacher have noticed any features that could connect these children.
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Biodegradable Waste: School Project for Lower Secondary School
Dvořáková, Kateřina ; Pavlasová, Lenka (advisor) ; Skýbová, Jana (referee)
The proper way to manage biological waste has only recently become a topic of discussion and the public still does not have enough information about it and does not have a comprehensive opinion. In order for bio-waste to be properly managed, knowledge of this topic and positive attitude towards it is necessary, in class this could be achieved by activating pupils through project based education. Teaching in projects is a great way to understand the issue, which can influence pupils' attitudes towards bio-waste management. The aim of this diploma thesis is to create a project on the topic of biodegradable waste, and then to find out how the knowledge and opinions of students about bio-waste have changed. The created project was verified at the lower secondary school, for which it is primarily intended. A total of 54 6th-year pupils was involved in this project. They were given a pretest before the start of the project, finding out the initial knowledge about bio-waste and their opinion on the classification of bio-waste. After the project, the pupils completed a posttest and by comparing the individual answers, it was determined whether and how the knowledge of the tested pupils and their attitude towards the topic changed. The answers of individual pupils in the pretest and posttest were evaluated...
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Mass Media and Their Role in the Mechanism of Legal Regulation
Dvořáková, Kateřina ; Agha, Petr (advisor) ; Havel, Tomáš (referee)
The aim of this thesis is to show how mass media can affect the legislative process. This is shown generally as well as specifically - using the legislative process in the Czech Republic as an example, which is illustrated by a specific case, in which media pressure resulted in the change of legislation. This thesis is divided into four chapters. The first two are theoretical, the third chapter presents a case study and the last chapter draws conclusions from the previous three. The first chapter shows law as an open system, which develops while communicating with the other subsystems of society. Sociological approach to law is presented, as well as selected concepts from sociology of law. Some crucial concepts from law theory are defined. The last part of the first chapter presents the legislative process in the Czech Republic, which is being defined in the broad meaning of this concept. The theme of the second chapter is mass media - first its definition, followed by presentation of selected concepts of relationship between mass media and society, with emphasis on agenda-setting and framing. The third chapter presents a case study of a successful campaign for change in legislation - mass media campaign associated with the premiere of the documentary film Smejdi in Czech cinemas. Role of the...
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Proposal for Changes of Marketing Mix of concret Company
Dvořáková, Kateřina ; Vopatová, Iveta (referee) ; Mráček, Pavel (advisor)
This master thesis deals with the proposal of changes in the marketing mix of a particular company. These suggestions could lead in the future to get new customers and strenghten loyalty to existing customers. The master thesis is divided into three essential units. The first one will introduce theories needed to carry out the following part, which is the analysis of this company and the necessary analyzes. For the processing of the last design part, these analyzes are necessary.
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