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Endocrine disruptors and their impact on mammalian oocyte developmental competence
Štenglová, Anna ; Němcová, Lucie (advisor) ; Ješeta, Michal (referee)
Endocrine disruptors (EDs) are defined as substances of exogenous origin that disrupt endocrine system. EDs are found in significant amounts in the natural environment, plastic products and flame retardants, leading to unavoidable exposure. Due to their broad effects, several organizations/ conventions aim to regulate their presence in the natural environment and limit, or even eliminate their production. By entering the body, they negatively affect development, reproductive, nervous or immune systems of various animal classes through hormones. Modified hormonal levels are associated not only with fertility issues, but also with physiological abnormalities, osteoporosis, depression or metabolic diseases. EDs affect the female reproductive system through hormonal modifications of the HHG axis, which can lead to an earlier pubertal onset in some cases. Under the influence of EDs, impairments can also be observed in the process of steroidogenesis, development of follicles and oocytes, particularly through meiotic defects, which can lead to premature ovarian failure or infertility. Multiple chemicals disrupt the females reproductive system across several generations through epigenetic effects. This work summarizes knowledge about these ubiquitous substances and their impact on female reproductive...
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High dynamic range rendering of virtual 3D scenes
Goncearenco, Vadim ; Chlubna, Tomáš (referee) ; Pečiva, Jan (advisor)
Tato bakalářská práce je zaměřena na téma Vysokého Dynamického Rozsahu (HDR), konkrétně různých HDR technik, které jsou široce používány v oblasti počítačové grafiky. Navíc se zabývá Vulkan API a jeho aplikací pro HDR vykreslováni virtuálních 3D scén. Praktická část této práce je aplikace pro renderování 3D scén, jejímž účelem je demonstrovat praktickou implementaci popsaných HDR technik, jako jsou globální operátory mapování tónu (fotografické, filmové a založené na ACES), lokální operátor mapování tónu založený na bilaterálním filtru, dynamická adaptace oka, exposure fusion a pokročilý bloom efekt.
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Exposure
Römerová, Denisa ; Vaněk, Vojtěch (referee) ; Gravlejs, Ivars (advisor)
Project Exposure is a card game and series of photographs with educational character. Players should understand principle of exposition and get awareness of history of photography after game.
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Possibilities of Companies Advertisement of Fairs
Budínská, Lucie ; MBA, Kateřina Čapková, (referee) ; Dvořák, Jiří (advisor)
The bachelor's thesis is focused on promotion EXCON copmany, Ins. at the trade fairs. It contains information about the company being analyzed, the general advertising and advertising at trade fairs. Methods and examples of promotion at the trade fair, ways to prepare and implement the exhibition to meet all the required targets. Above all this bachelor's thesis is focused on proposition of the optimal structure of advent at the trade fairs.
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Nanosafety and the Current Trends in the Risk Assessment of Nanoparticles
Valovič, Stela ; Poláčik, Ján (referee) ; Adamec, Vladimír (advisor)
This diploma thesis deals with the current state of nanosafety. The aim of this paper was to review and critically analyze approaches to facilitate the risk assassment of nanomaterials. In the first part it provides an overview of the most important methods and software tools that are used in this field. Methods were analyzed against a set of relevant criteria. Criteria include consideration of exposure, life cycle and physicochemical properties, transparency, applicability and the field of application. Different criteria were chosen for the software tools. Based on results, a new approach was suggested. The approach takes the form of a diagram based on questions. The purpose of the suggested approach is to recommend the most relevant method, tool or their combination to assess the safety of a nanomaterial depending on known characteristics. The approach was also implemented in a software tool.
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Realization of digital exposure meter
Vacula, Richard ; Michal, Vratislav (referee) ; Frýza, Tomáš (advisor)
Bachelor’s thesis deals with the history of light measurement, ways of measuring exposure and constructions of exposure meters. In the last chapters it is treated of the realization of digital exposure meter. This project also examines the characteristics of digital light sensor ISL29003 and its use for purposes of measuring exposure.
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Study of Formation and Elimination of Acrylamide in Food Matrix during Heat Treatment.
Marková, Lucie ; Jarošová, Alžběta (referee) ; Buňka, František (referee) ; Šimko, Peter (advisor)
Acrylamide (AA) is a probable human carcinogen and undesirable contaminant which is produced by the reaction of reducing sugars with asparagine in plant foods during their thermal treatment above 120 °C. AA is most often determined by GC-MS and LC-MS/MS in isolates from the matrix in a wide range of foods. According to our observations, AA intake from food is higher among young people (from 1.8 to 3.8 µg/kg bw/day), which is consistent with the estimations of JECFA FAO/WHO from the year 2006. Considering the health risk, it is recommended to reduce AA formation in food during its processing, in particular exploiting the available experience. The aim of this thesis was to extend the knowledge of the possibility of AA elimination in selected types of thermally processed foods. The study was focused on cereal foods that contribute significantly to AA exposure, especially bread and sweet biscuits. The whole AA content in the bread is in the crust, which represents 5-15% of the bread. Crust of home-made bread contains approximately 30-75 µg/kg, however the marketed bread contains 2 to 10 times more of AA. This is due to the composition of bread mix, preparation conditions and baking. For maintaining the quality of home-made bread during the dry mixture shelf-life, optimization of bread mixtures was designed by increasing of yeast content, which proved positive effect on the reduction of AA content at sufficiently high activity of the yeast. Monitoring of AA content in assortment of sweet bakery products showed higher levels of AA in diabetic biscuits containing fructose instead of sucrose. Three of them even exceeded the reference value (500 µg/kg) more than 1.5 times for commodity "cookies". Elimination of AA by applications of the enzyme asparaginase has been designed for minimal interference in technology of their production. The concentration of the enzyme and the appropriate method of its use in industrial environment have been tested previously in model systems. In optimized conditions of the enzyme application, AA content in diabetic biscuits was reduced by more than 40% without affecting the organoleptic properties of the final product. Effect of the antioxidants on AA formation was also part of the study. AA content in gingerbread was reduced efficiently by the use of fennel, anise, cloves, vanilla and white pepper (by about 9-21%). Conversely, coriander and cinnamon significantly increased its content (by 18-54%). Since correlations between the DPPH• radical quenching activity of the spice extracts and AA content was not observed, the final content of AA was probably influenced by the chemical composition of spices and reactivity of the individual components in the matrix. Investigated methods appear to be suitable ways of elimination AA in some foods; however their specific use must be optimized with regard to the composition of the food, processing and the technology used. Estimated impact of application of the above-mentioned methods to the overall elimination of AA exposure showed that its intake in high school students from the Czech and Slovak Republic can be reduced on average by 10%. This decrease is a success to reduce the possible risk of cancer disease by eating foods with a high AA content. It is also important piece of information for food producers for further development of relevant methods for AA elimination which would help to reduce the AA intake from foods even more.
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The Gallery of Brno Grand Prix
Sikora, Zbigniew ; Boleslavská, Yvona (referee) ; Žalmanová, Petra (advisor)
The main task of this thesis was to create an architectural study of The Gallery of Brno Grand Prix based on previous urban study from previous semester works. The proposal is focused on the iconic circuit’s former glory restoration, on providing new content for raceway complex and creating decent and presentable place for the presentation of the rich history of Czech and Czechoslovak motorsport. The result is a study of an object that meets these needs while respecting the historical and morphological values of the place. The building creates new themed attraction and creates the potential for further development of near circuit.
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