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The awareness of health professionals in the field of gynecology about prevention of cervical cancer
Havlíková, Tereza ; Sláma, Jiří (advisor) ; Šimonová, Daniela (referee)
The bachelor thesis deals with the topic of the awareness of health professionals in the field of gynecology about the prevention of cervical carcinoma. The thesis summarizes basic information about primary and secondary prevention, risk factors and clinical symptoms of cervical carcinoma. It also includes information on the diagnosis and subsequent treatment of patients with cervical carcinoma. The main aim of the study was to identify which group of health professionals would have the greatest knowledge of cervical cancer prevention. A total of four research hypotheses were established, of which three were confirmed and only one was disproved. A quantitative type of research was chosen to address them. Data collection was carried out by means of a questionnaire survey conducted at the Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital in Prague. A questionnaire of twenty-six questions was distributed in paper form among local doctors, midwives and nurses. The final size of the research sample was one hundred respondents. All questions were answered completely voluntarily and anonymously. Tables and graphs summarizing the results of the survey were produced as part of the data analysis. The main finding was that the group of doctors was much more aware of the...
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The importance of cell-free HPV DNA detection
Milt, Petr ; Saláková, Martina (advisor) ; Horníková, Lenka (referee)
Human papillomaviruses (HPV) are small, nonenveloped DNA viruses that are abundant in the population. They are sexually transmitted or spread by close contact with mucosa and skin. Papillomaviruses can cause lesions and warts on the skin and mucosa. In addition, high-risk HPV types, especially HPV 16 and 18, are associated with squamous cell carcinomas such as cervical cancer, oropharyngeal cancer and carcinomas of the vulva, anus, penis and vagina. Early detection and the right evaluation of the risk of recurrence are crucial for effective treatment. Cell-free DNA released from cells into body fluids has potential in cancer diagnosis. Cell-free circulating HPV DNA, in the blood of patients with HPV-associated cancers is a promising and highly sensitive biomarker, useful for monitoring treatment efficiency, early detection of the disease and estimation of recurrence risk. Key words: HPV, carcinogenesis, cfDNA, cfHPV DNA, significance of detection, cervical cancer, oropharyngeal cancer
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Selected Bacterial and Viral Infections Transmitted through Sexual Contact
Tesařová, Kateřina ; Pavlasová, Lenka (advisor) ; Ehler, Edvard (referee)
Selected bacterial and viral infections transmitted through sexual contact The abstract This thesis deals with selected bacterial and viral venereal disease. It is an STD (Sexually Transmitted Diseases) transmitted mainly through sexual contact. The elaborated retrieval work deals with the occurrence of these selected infections - chlamydia, gonorrhea, chancroid, syphilis, hepatitis B, AIDS, genital herpes, genital warts and cervical cancer. Its task is a summary of the issue of sexually transmitted diseases, a detailed introduction to current information and results of scientific research. The attention is paid to the individual diseases, the general characteristics of viruses or bacteria, symptoms and mode of transmission. Further the study points to ways of diagnosis and treatment, epidemiological incidence of infection. Last but not least the emphasis is on prevention. Keywords: sexually transmitted disease, chlamydia, gonorrhea, chancroid, syphilis, hepatitis B, HIV / AIDS, genital herpes, genital wals, cervical cancer
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Sexuality of patients after simple and radical hysterectomy for bening or malignant gynaecologic disease
Vrzáčková, Petra ; Sláma, Jiří (advisor) ; Tošner, Jindřich (referee) ; Kubíček, Vladimír (referee)
Background: Cervical carcinoma is frequently diagnosis of young, sexually active women. Radical hysterectomy, as a basic therapeutic modality of early stages of cervical cancer, has very positive oncogynaecologic results. On the opposite site it has it's significant morbidity including bladder and rectal dysfunctions, lymphedemas, and deterioration in patient's sexual life. Methods: Data of forty one patients undergoing radical hysterectomy for cervical cancer were used for analysis, as well as data of forty nine patients undergoing simple hysterectomy for benign gynacologic disease and fifty three healthy controls Participants filled out sexual function and quality of life questionnaires before surgery and three and six months postoperatively. Results: The most important finding was statistically significant worsening in objective arousal in cervical cancer patients (p = 0,041). Also decrease in libido and higher frequency of dyspareunia was registered. Patients undergoing simple hysterectomy showed decreasing trend in sexual dysfunctions, mainly in severe dyspareunia. Conclusions: Radical hysterectomy for cervical carcinoma has a risk of arousal disorder, libido decrease and worsening of dyspareunia. Psychosexual counselling decreases frequency of early postoperative sexual dysfunctions.
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Psychological adaptation demands to oncological diagnosis of cervival cancer: quality of life and posttraumatic growth in the phase of disease remission
Hejnová, Kateřina ; Loneková, Katarína (referee) ; Hrachovinová, Tamara (referee)
The presented thesis deals with psychological demands and specific factors of the adaptation to the oncological diagnosis "cervical cancer." The focus is on quality of life and posstraumatic growth of patients in the phase of disease remission. The theoretical part first introduces specifics of cervical cancer with consideration of patients' experience and then provides the issue of coping with the oncological disease in terms of coping and defense mechanisms. Then it elaborates the psychological adaptation to cancer disease with focus on other aspects linked to society, patients and disease altogether with problems in coping with oncological diagnosis. The theoretical part of the study is concluded with the description of demands and patients' experience in each clinical stage of the disease. The chapter of disease remis;sion is focused on theoretical background of life quality and posttraumatic growth concepts including an overview of tools for quantitative evaluation. The empirical part describes supporting psychological and other aspects, which help women to cope with cervical cancer. It also pays attention to the change of these aspects and needs with regard to clinical stage of the disease (treatment, remission and relapse) and specific demographic data (age, children, size of residence,...
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Perineural spread of pelvic tumors: mechanism and diagnosis
Čapek, Štěpán ; Sameš, Martin (advisor) ; Haninec, Pavel (referee) ; Hořínek, Daniel (referee)
Perineural spread of pelvic tumors mechanism and diagnosis Abstract Neoplastic lumbosacral plexopathies are infrequent affections of the lumbosacral plexus. Cases with minimal or non-specific finding on imaging can be particularly puzzling to diagnose. We describe a series of patients with perineural spread from the site of the primary tumor along the visceral autonomous nerves to the lumbosacral plexus and further proximally to the spinal nerves and even intradurally and also distally to the sciatic nerve. On series of 17 patients diagnosed with perineural spread of pelvic malignancy we describe characteristic clinical presentation and imaging finding. In many of these cases a tissue biopsy is necessary to finalize the diagnosis. We describe operative technique of targeted fascicular biopsy of the sciatic nerve and our experience with this procedure. On series of 117 patients, we report the outcome and complication: diagnostic yield was 84.8% and complication rate was 2.7 %. If a tissue sample is needed to conclude the diagnosis, targeted fascicular biopsy does increase the yield at an acceptable complication rate. Perineural spread of pelvic cancer is a new clinical-pathological entity with an unknown natural history or ideal treatment strategy. Based on the imaging finding in this group we present a...
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Evaluation of postoperative lymphoedema after differently radical surgery for vulvar and cervical carcinoma
Nováčková, Marta ; Halaška, Michael (advisor) ; Špaček, Jiří (referee) ; Mlynček, Miloš (referee) ; Kučera, Eduard (referee)
The aim of this study was a prospective detection of postoperative lymphedema of the lower limbs in patients after the surgery for cervical and vulvar cancer using different methods of examination and their comparison and monitoring of postoperative complications and quality of life. Totally 78 women were followed after the surgery for cervical cancer and 36 for carcinoma of the vulva. Due to the radicality of the surgery the patients were divided into the conservative and radical groups. Lower limbs lymphedema were evaluated preoperatively and 3, 6 and 12 months after the surgery by the measurement of the lower limbs circumference, multifrequency bioelectrical impedance analysis (MFBIA) and subjective feeling. Quality of life using the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires was evaluated before and 6 and 12 month after the surgery. 12 months after the cervical cancer surgery 35.9 % of patients reported subjective lymphedema, 37.18 % lymphedema were objectively diagnosed by the measurement of lower limb circuits and in 52.56 % of cases the increase of amount of extracellular fluid was detected by the MFBIA Ri/R0 method. The prevalence of lymphedema after the surgery for vulvar cancer reached 19.44% by the subjective assessment, 38.89 % by the measurement of...
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The role of sentinel lymph node biopsy in the management of patients with early-stage cervical cancer
Kocián, Roman ; Cibula, David (advisor) ; Roztočil, Aleš (referee) ; Špaček, Jiří (referee)
The sentinel lymph node biopsy is part of recommended surgical staging guidelines in patients with early stages of cervical cancer. High success rates of bilateral detection of SLN are achieved in sites with adequate experience with this procedure. The sentinel lymph node biopsy without systematic pelvic lymph node dissection is currently considered inadequate procedure for stages IB to IIA of the disease. One of the benefits of sentinel lymph node detection is extensive histopathological examination using the ultrastaging protocol enabling detection of small metastases (i.e. micrometastases). At the moment, there is lack of evidence about oncological safety of sentinel lymph node biopsy which might replace systematic lymph node dissection in the future. Prognostic significance of micrometastases is also controversial due to the lack of data about their potential presence in non-sentinel lymph nodes in cases with negative sentinel lymph nodes. This dissertation deals with the concept of sentinel lymph node biopsy in the cervical cancer and focuses on several topics. We have shown that the presence of micrometastasis is associated with significant negative impact on patients' prognosis on the largest retrospective cohort of patients ever published. Only 67% of patients with micrometastasis have...
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Quality of life in patients with cervical cancer
Králová, Eva ; Raudenská, Jaroslava (advisor) ; Jirkovský, Daniel (referee)
My bachelor thesis deals with the quality of life in patients with locally advanced cervical cancer. The aim of the thesis is to assess the quality of life of this group of patients in the period after the completion of treatment and the influencing factors, and to compare the differences in the assessment of the quality of life for various time intervals from the completion of treatment. The theoretical part of the thesis gives an overview of cervical cancer, including the epidemiology, risk factors, classification, diagnosis, therapy and its early and late side effects, and the prevention of the disease. Definition of the quality of life is given together with the significance of the assessment of the quality of life. The empirical part is aimed to find out the subjective assessment of the quality of life and the level of functional status of the patients. The aims of the thesis and working hypotheses are defined, methods of the survey are described and the group of patients surveyed is presented. Patients were surveyed with a non-standardized questionnaire and the questionnaires for the assessment of the quality of life EORTC QLQ C-30 and QLQ CX-24. The data are presented in the form of graphs and tables with comments. The results of the survey are given together with their comparison to other...
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