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Food intolerance
Jirkovská, Magdaléna ; Tlaskalová - Hogenová, Helena (advisor) ; Křížan, Jiří (referee) ; Seifertová, Eva (referee)
This bachelor's thesis is a literature research that deals with food intolerances. It focuses primarily on celiac sprue, describes the disease, its clinical manifestations, symptoms, complications, methods of investigation, diagnosis and treatment. Part of the thesis deals with relationship of gluten to other diseases such as gluten sensitivity or autism.
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Coeliac Disease and its Effect on Everyday Life
Hadravová, Petra ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
Coeliac disease is an autoimmune digestive disease that damages the villi of the small intestine and interferes with absorption of nutrients from food, and which is among the most common disease of the immune system. Essentially the body is attacking itself every time a person with coeliac consumes gluten. Currently is coeliac untreatable, the only treatment is a lifelong gluten free diet. Low public awareness and frequent late diagnosis usually causes unnecessary discomfort. For this reason are the most important aims of my work define basic knowledges about coeliac disease, symptoms, diagnosis and treatment. At the same time it should also provide an information, especially to general public about the effect of the disease on the quality of life.
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The effect of gluten-free diet on β-cell residual capacity, immune function and gut microbiome in children with newly diagnosed type 1. diabetes
Neuman, Vít ; Šumník, Zdeněk (advisor) ; Pelikánová, Terezie (referee) ; Škvor, Jaroslav (referee)
The effect of gluten-free diet on β-cell residual capacity, immune function and gut microbiome in children with newly diagnosed type 1. diabetes Abstract The pathophysiology of the onset and progression of type 1 diabetes (T1D) is not fully understood. Gluten has a proinflammatory effect on the immune system and is therefore considered as one of the factors affecting the onset and progression of T1D. The aim of the thesis is to allow a complex insight into the role of the GFD on the residual β-cell capacity, T1D control, gut microbiome, gut permeability, subtypes of immune cells and the effect of gut microbiome transfer into germ-free non-obese diabetic (NOD) mice on the incidence of diabetes. On the group of 45 children with T1D (26 intervention group, 19 control group) we proved the association of the GFD with slower decrease of β-cell residual capacity (the difference in the trend of C-peptide decrease 409 pmol/l/year; p = 0,04) and lower HbA1c (by 7,8 mmol/mol; p=0,02). We also described the changes in the gut bacteria that were differentially abundant after the administration of the GFD and the changes in abundance of the regulatory and effector immune cells. We showed there was no change in the gut permeability with respect to the study group. We also proved that the transfer of human gut microbiota...
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Importance of micronutrients in patients with celiac disease
Dolanská, Pavla ; Humlová, Zuzana (advisor) ; Meisnerová, Eva (referee)
This diploma thesis deals with the issue of celiac disease with a focus on the importance of micronutrients in treatment and clinical monitoring of patients with celiac disease. The thesis is divided into two parts, theoretical and practical. The theoretical part is divided into two chapters. The first chapter deals with celiac disease in general - history, epidemiology, pathogenesis, clinical classification, clinical manifestations, diagnostics and complications of celiac disease. Procedures for clinical monitoring of patients with celiac disease are also discussed. Last but not least, cereal proteins are analysed with a focus on gluten and its importance in the pathogenesis of celiac disease. The second chapter describes gluten-free diet as the only available possibility how to treat celiac disease. Furthermore, the pitfalls of the gluten-free diet and its possible nutritional imbalances associated with a gluten-free diet. The issue of gluten-free products is discussed, both in terms of legislation and in terms of selecting suitable foods. The possibilities of supplementation of micronutrients in celiac and other investigated possibilities of treatment of celiac disease outside the gluten-free diet are also mentioned. The practical part of this diploma thesis has two main goals. The first goal is...
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Comparison of the options and financial demands of a regular diet with gluten-free diet
Kosíková, Monika ; Starnovská, Tamara (advisor) ; Floriánková, Marcela (referee)
In the Czech Republic, 50 000 people are diagnosed with Celiac disease and the only known treatment for it is a gluten-free diet. For such patients, gluten consumption can provoke inflammation of a small bowel that can result in heavy consequences. Gluten is a protein contained in wheat, rye, barley, and oats and plays an important role in food production, because of its properties. Bakery and other gluten-free products are produced from other types of cereals. They also require a special technological process, separate spaces, and have a much smaller target group of consumers, which can increase their price at the end. People following a gluten- free diet have to be very careful while eating in restaurants and canteens because even a small amount of gluten can harm their health. Health insurance companies in the Czech Republic contribute various amounts to the GFD, however, mostly only for children. The goal of the research was to find out whether and for how much gluten-free food is more expensive than the ordinary one; and how the availability of gluten-free products and meals is assessed by people who have to eliminate gluten due to health reasons. To achieve the goal, quantitative research with a questionnaire survey was used. The questionnaire with 17 questions was filled in by a hundred...
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Relationship of students of the selected secondary schools to the alternative ways of eating
Fialová Krejzová, Lenka ; Váchová, Alena (advisor) ; Kovaříková, Miroslava (referee)
The diploma thesis deals with the relationships and opinions of students of selected secondary schools, which are connected with alternative ways of eating. The theoretical part contains basic information about rational nutrition, individual nutrients, there is a comparison of the food pyramid and a healthy plate. Last but not least, alternative diets are also clarified and then information on five specific types of alternative diets is given. In the individual subchapters, vegetarianism, veganism, raw food, paleo diet and a gluten-free diet are mentioned. The aim of the practical part is to find out the opinion of students of selected secondary schools on alternative ways of eating. These are my chosen secondary schools in the Rakovnicko region. A questionnaire survey is used as a research tool. Based on the data obtained, the questionnaire was evaluated and the results were converted into tables and graphs, which are always commented. 187 respondents answered the questionnaire. It was found that 19 of all respondents have nutrition-related health restrictions. The surprising result is that students did not learn about alternative meals primarily at school, but from their own resources (friends, family, etc.). The results of the questionnaire survey point to the fact that secondary school students...
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Effect of gluten-free diet on immune cell subsets in the NOD mouse model of type 1 diabetes
Tejklová, Tereza ; Funda, David (advisor) ; Krulová, Magdaléna (referee)
Type 1 diabetes (T1D) is an autoimmune disease leading to destruction of insulin-secreting pancreatic -cells. Environmental factors e.g. exposures to infections, dietary components play a substantial role in etiopathogenesis of T1D and are responsible for rapid increase of T1D incidence in past decades, preferentially in developed countries. Despite long record of T1D research no causative cure or efficient prevention exists. While gluten displays proinflammatory properties, gluten-free diet (GFD) has been documented by several studies as a strong diabetes- preventive environmental factor in spontaneous animal models of T1D, mostly in NOD mouse. The aim of this thesis is to better characterize effects of GFD on the immune system of NOD mouse. Using flow cytometry, we compared effects of GFD vs standard (STD) Altromin diets on NK cell subsets, Tregs, as well as other regulatory cell subsets and their cytokine profile in prediabetic SPF NOD females that were exposed to the diets since "in utero". A reference diabetes incidence in NOD females in our SPF facility kept on STD and GFD was recorded. Diabetes-preventive capacity of GFD were tested by using the NOD-SCID model of diabetes transfer, in which splenocytes from at-onset NOD females kept on GFD or STD were transferred to NOD-SCID recipients....
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Life of coeliac and his family in these days
Machovcová, Denisa ; Kohout, Pavel (advisor) ; Pavlík, Vladimír (referee)
Name: Life of coeliac and his family in these days Aim: The aim of my diploma thesis is to map life difficulties of people with celiac disease. First of all, it is a problem with gluten-free diet which is essential for celiac disease. Problems with eating out, shopping for ingredients for meal preparation at home, expensiveness of this eating, and last but not least, support from insurance companies and the state. Methods: The theoretical part includes findings about celiac disease as an illness, it means the characteristics of its origin, diagnostics and treatment. Furthermore, findings about gluten- free diet and problems related to this kind of eating were worked. Last but not least, diet and availability of food for gluten-free eating are mentioned. I applied a survey method in the practical part, in which case an anonymous survey was created electronically by using Google forms, and then sent out via internet. The survey was filled out by 296 respondents. Outcome: We can see from the outcomes that most of the respondents sometimes break the diet due to social integration. Furthermore, we observed the frequency of eating in restaurant services, in which case most of the people sometimes visit, it means less than once a week. The reason of sporadic or even no visit to restaurants is bad...
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