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"Why am I trying to become what I don't want to be?" The Corrupted American Dream in the Selected Arthur Miller's and Tennessee Williams's Dramas
Hájková, Hana ; Ulmanová, Hana (advisor) ; Wallace, Clare (referee)
In my thesis, I focused on the challenges of the American Dream and its damaging demands. I compared these aspects to The Glass Menagerie, All My Sons, and Death of the Salesman, plays by Tennessee Williams and Arthur Miller, two playwrights concerned with similar issues in the 1940s and 1950s. Each chapter was introduced by Robert Frost's poem related to its topic. This element was added as a chapters' introduction to express the universality of the depicted issues and to tight the sections together under one pattern. In the theoretical part of the thesis, I concentrated on the 40s and 50s America and its features and the historical development of the American Dream. This section's main influences were works by Rodney P. Carlisle, Richard A. Schwartz, Stephanie Coontz, and Jim Cullen. With their books about America and its historical background, Carlisle, Schwartz, and Coontz provided a base for the factual context of this thesis. Cullen's work on the American Dream was used as the primary source for understanding the reasons behind the Dream and its historical development. The whole thesis was supported by arguments from Lauren Berlant, John W. Thoburn and Thomas L. Sexton, and Piotr Sztompka. Berlant's work on cruel optimism provided a possible explanation of particular behavior that accompanied...
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Planning care for clients with Alzheimer's disease in the Hradec Králové region
Hájková, Hana ; Vrzáček, Petr (advisor) ; Hradcová, Dana (referee)
The theme of the thesis is the issue of planning social services for people affected by Alzheimer's disease and other types of dementia in the territory of the Hradec Králové region. Alzheimer's disease is among the most common causes of dementia, and the number of patients with the disease continues to grow. It is the increase in the number of clients with the disease that creates a new challenge to ensure the availability of social services, so that an individual approach is maintained in view of the patients' specific needs. The thesis contains a theoretical and an empirical part. The theoretical part briefly describes the clinical picture of Alzheimer's disease. Furthermore, this section focuses on the incidence of dementia both globally and in the territory of Europe. Some organisations and strategic documents dedicated to supporting and caring for those with dementia in the territories of France, Sweden and Switzerland are listed in this section. There is also a chapter that gives an idea of individual types and forms of care for clients with dementia manifestations in the Czech Republic. It includes an explanation of basic concepts such as: social services, social services network, community planning. As the work deals with care planning in the Hradec Králové region, the Mid-Term Plan for...
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The promoter of c-myc oncogene as a target for a novel type of heterocyclic cations stabilizing G-quadruplex.
Pohlová, Lenka ; Šmídková, Martina (advisor) ; Hájková, Hana (referee)
Targeting oncogene promoters: a novel heterocyclic cations as G-quadruplex stabilizing ligands Lenka Pohlová Abstract: The diploma thesis studies an effect of newly synthesized group of compounds - helquats - on the expression of c-myc as a major player in malignant transformation and tumorigenesis via the stabilization of G-quadruplex in c-myc promotor. The G-quadruplex c-myc stabilization ability was tested for 101 helquats using dual luciferase reporter assay. The G-quadruplex c-myc stabilization ability was found for 13 helquats by this method. 8 successful helquats was selected by a comparison of the results from dual luciferase reporter assay and FRET melting assay. Effect on cell viability of tumor (HeLa S3) and non-tumor (HUVEC) cell lines was evaluated for these 8 helquats. Three of them exhibited cytotoxic effect on tumor cells but no effect was observed on viability of non-tumor cells. Moreover, an effect of these 3 helquats on c-myc expression on both mRNA and protein level, where significant effect on c-myc mRNA expression was not found for most of incubation periods. The 30% decrease in mRNA level was observed only for 24 hours incubation period for two helquats (LS702 and MJ656). The decrease in the expression on protein level was observed for all tested helquats, and helquat LS702 had the...
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"A time to live and a time to die" in Theological Ethics
Hájková, Hana ; Milfait, René (advisor) ; Svobodová, Zuzana (referee)
This bachelor thesis introduces the Leben hat seine Zeit, und Sterben hat seine Zeit handbook by the society of Gemeinschaft Evangelischer Kirchen in Europa. From this handbook the main argumentation theological-ethic tools used in discussions concerning the questions of the end of a human life are taken. The Jewish-Christian religion attaches unique dignity to a human life, which is assumed on the basis of imago Dei or imago Christi. Other aspects related to a human life rise from this dignity. They are aspects such as justification through religion, autonomy of a human being in which the limits among freedom, dependence and responsibility are being clarified. Furthermore, the thesis shows how Gemeinschaft Evangelischer Kirchen in Europa puts its beliefs (related to the questions appearing at the end of a human life) into practice. Consequently, the thesis reacts to the outputs of the handbook. Notions concerning euthanasia are clarified in a way they are used in Europe nowadays. Moreover, three main arguments that (according to the handbook) are fundamental for a discussion with dying and incurably ill people are being presented. It is though the human dignity, autonomy and the right to spread the palliative care that promises creating a humanly dignified life even when it comes to its end. Powered by...
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DNA methylation changes in patients with acute myeloid leukemia
Hájková, Hana ; Haškovec, Cedrick (advisor) ; Hejnar, Jiří (referee) ; Reiniš, Milan (referee)
DNA methylation is a well-established epigenetic mechanism regulating gene expression. It has essential functions in cells under physiological as well as pathological conditions. In acute myeloid leukemia (AML), aberrant DNA methylation has been confirmed in the pathogenesis and progression of the disease. Changes in DNA methylation of promoters, or other regions, are studied primarily with respect to pathways that are involved in tumor transformation and DNA methylation impact on prognosis. Clinical importance of DNA methylation has been confirmed by a number of recent publications. According to the Cancer Genome Atlas (TCGA) Research Network, mutations of genes involved in DNA methylation are found in 44% of AML patients at diagnosis. However, the impact of these mutations on specific DNA methylation and gene expression remains controversial. We examined 79 AML patients at diagnosis for DNA methylation of 12 selected genes (CDKN2B, CALCA, CDH1, ESR1, SOCS1, MYOD1, DAPK1, TIMP3, ICAM1, TERT, CTNNA1, EGR1) - some of them proved as tumor suppressor genes and 24 HOX genes, and in parallel for mutations in DNMT3A. We observed lower levels of DNA methylation (P<0.0001) as well as lower numbers of concurrently hypermethylated genes (P<0.0001) in patients with DNMT3A mutations. Our study of the impact of...
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Transfer pricing and the Arm's length principle
Hájková, Hana ; Kemény, Irena (advisor) ; Hollmannová, Monika (referee)
The Diploma Thesis is devoted to the Transfer pricing problematic, whereby the Transfer Pricing and the Arm's length principle as such are defined, further the Czech and Slovak transfer pricing law is presented and the different transfer pricing together with their possible usage are described. The work is divided into 7 sections, section 1 - 5 is basically a theoretical description of the topics stated above. Section 6 comments the actual situation and development in the transfer pricing area around the world and finally section 7 demonstrates o an example the practical transfer pricing analysis with all its relevant aspects. The aim of the analysis was to present the possible ways of determining the appropriate transfer pricing method and the evaluation of the financial data when applying the selected method. The presented case study was based on an analysis of a group of 3 companies and was in general oriented on two different kinds of transactions. The application of various transfer pricing methods was demonstrated and the correctness of the transaction conditions was commented. Powered by TCPDF (www.tcpdf.org)
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