National Repository of Grey Literature 215 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
A teacher's profession at the secondary school during the coronavirus crisis
Widemannová, Bohuslava ; Murad, Salim (advisor) ; Svobodová, Zuzana (referee)
Reflection The diploma thesis deals with the topic of teaching during the coronavirus crisis. The coronavirus brought not only a disease, but also a pandemic which had global consequences for the population. People were affected by social, economic, psychological and physical consequences. This thesis deals with the impact of the pandemic on education and the form of teaching during this period. The teaching profession that was interrupted and limited at one point. Teachers were faced with a new situations brought by the closure of schools. A considerable amount of space is devoted to teaching itself, especially distance learning and it mentions its positives and negatives. A short cross-section of the history of teaching and its interruption is also interesting. The thesis is divided into two parts: theoretical and practical. The theoretical part is devoted to important concepts related to the coronavirus disease, the occurence and development of the pandemic itself. It also deals with the beginning of the coronavirus crisis in the Czech Republic and what effects recieved Czech education. Then the form of teaching before the pandemic is explained. It presents a form of distance education which became the only solution in this time. A short history of education in the Czech Republic is also mentioned, as...
Educational management of pedagogical staff
Nováková, Andrea ; Tureckiová, Michaela (advisor) ; Svobodová, Zuzana (referee)
The diploma thesis analyzes the current problems associated with further education of pedagogical staff in the capital city of Prague. The theoretical part defines the basic concepts, characterizes the current system of education, new trends in further education of teachers and provides an overview of further education in some EU countries. The practical part evaluates the results of a research survey, which includes the analysis and comparison of data obtained from structured interviews, questionnaires and annual reports of schools. Problems in further education of pedagogical staff, its quality, method of implementation and factors that affect it are, among other things, assessed with regard to the specific needs of teachers for working with pupils with special educational difficulties. KEYWORDS Adult educational, education, educational management, further education, quality of education, lector, pedagogical staff
Automated preparation of anti-COVID magnetic immunosorbent
Křížová, Lucie ; Svobodová, Zuzana (advisor) ; Smělá, Denisa (referee)
The target of the diploma thesis is the automation of the manual preparation of anti-COVID-19 magnetic immunosorbent. The theoretical part of the work is focused on the research processing of information about the SARS-CoV-2 virus causing the disease COVID-19. The basic characteristics of the disease, its causative agent, clinical picture, methods for detecting the SARS-CoV-2 virus in the human body, and treatment are described here. Furthermore, the principle of the LIS method is described here and the methods of its use in other areas of analysis are described here. The experimental part describes how the manually demanding batch method for antibody immobilization on magnetic particles was converted to an automated method in the Lab-In-Syringe (LIS) system. To convert the batch method to LIS, a series of experiments, optimizations, and searches for analogies were carried out to fully automate the method with minimal operator involvement. Using the device, we prepared anti-COVID-19 immunosorbents, which were subsequently tested using the PCR method on patient samples in the laboratory of the University of Pardubice with BSL 3 protection Keywords: COVID-19, SARS-CoV-2, magnetic particles, Lab-In-Syringe, LIS
Evaluation of antibody quality for Endoglin detection in liver
Kejzlarová, Eliška ; Svobodová, Zuzana (advisor) ; Tripská, Katarína (referee)
The diploma thesis deals with endoglin, a transmembrane glycoprotein that can be cleaved to form so-called soluble endoglin, which then circulates in the blood. The theoretical part of the thesis is devoted to cardiovascular and liver diseases related to changes in the expression or level of endoglin in the blood and summarizes current knowledge about endoglin and its relation to various diseases. The experimental part of the thesis describes the selection of a suitable antibody against endoglin intended for western blot (WB). We have four anti-endoglin primary antibodies available from three manufacturers. The purpose was to test the antibodies and determine, which one had the best ability to detect endoglin in mouse tissue samples such as liver or aorta on WB. Affiblot was used to verify their ability to bind endoglin and also to compare their affinities to this protein. Newly developed patented dot-blot-based device. The binding of the used antibodies to endoglin was verified using the WB method and then the results of both methods were compared. The obtained results showed that the Abcam antibody has the most suitable parameters regarding specificity and sensitivity for the identification of endoglin in mouse tissue on WB. Keywords: endoglin, soluble endoglin, NASH, cirrhosis, non-alcoholic...
Immunohistochemical analysis of TRC105 effects on the liver fibrosis
Hamerníková, Veronika ; Němečková, Ivana (advisor) ; Svobodová, Zuzana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Biological and Medicinal Sciences Studijní obor: Pharmacy Author: Veronika Hamerníková Supervisor: RNDr. Ivana Němečková, Ph.D. Title of master thesis: Immunohistochemical analysis of TRC105 effects on the liver fibrosis The subject of this diploma thesis was the analysis of the expression of liver fibrosis biomarkers in mice liver. The aim of our work was to test the effect of the drug TRC105 (carotuximab) on a fibrotic liver model after 4 weeks of DDC (3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-colidine) administration. Collagen deposition and expression of α-SMA, GFAP and endoglin were examined and compared. Animals were divided into 3 groups: control group (n=6), DDC group (n=6) and TRC105 group (n=6). The control group was fed a standard diet, while the DDC and the TRC105 groups were fed a diet with 0.1% DDC. Physiological solution was administered to the control and DDC groups while carotuximab was administered to the TRC105 group. The analysis of fibrosis biomarker expression was then performed on fixed liver sections. Collagen expression was evaluated by Picro-Sirius Red staining and α-SMA, GFAP and endoglin expression by immunohistochemistry with fluorescence imaging. Histological staining of collagen...
System of employee development in selected organisation
Krajčinovská, Zdeňka ; Svobodová, Zuzana (advisor) ; Tureckiová, Michaela (referee)
The thesis dealing with the topic "System of employee development in selected organisation" focuses on the educational system of a company operating in the automotive industry. It is a medium-sized company with about 150 employees. The company has chosen a competency model as a training strategy to achieve its training goals, i.e. the company has developed a competency matrix that shows which competencies are necessary for the performance of each job position. The aim of this thesis is to analyse and describe the educational strategy of the company under study, to identify problem areas and to suggest possible improvements. The thesis is divided into a theoretical part, based on the study of the literature, and an empirical part, dealing with the investigation of the actual state of the functioning of the training system in the company by means of document analysis and structured interview with the HR manager. In the theoretical part, the theoretical knowledge of individual authors is examined to introduce the reader to the issues, there is, for example, an explanation of the basic concepts in the field of corporate training, the phases of training, training from the perspective of strategic or competency-based approach to training. The practical part establishes the research methodology, describes...

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