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Synthesis of purine derivatives with potential antimycobacterial activity
Finger, Vladimír ; Roh, Jaroslav (advisor) ; Doležal, Martin (referee) ; Brulíková, Lucie (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Doctoral Degree Program Bioorganic Chemistry Candidate: Ing. Vladimír Finger Supervisor: Assoc. Prof. PharmDr. Jaroslav Roh, Ph.D. Title of Doctoral Thesis: Synthesis of purine derivatives with potential antimycobacterial activity The theoretical part of this dissertation briefly summarizes basic data on tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb.). The epidemiological data published in the annual report of the World Health Organization (WHO) and the structure of drugs used in current TB therapy are presented. The theoretical section also gives a brief overview of the treatment of TB and mentions four compounds that are currently in phase II clinical trials. The mechanism of action of these compounds is inhibition of the enzyme decaprenylphosphoryl-β-D-ribose-2'-epimerase, specifically the DprE1 subunit. This enzyme plays an important role in the synthesis of mycobacterial call wall. The next part of the dissertation summarizes the results of research on potential purine and pyrrolo[3,2- d]pyrimidine antituberculosis agents derived from purine-6-one 10. Compound 10 was identified as derivative with moderate anti-TB activity (MIC99(Mtb) = 4 μM) in a high-...
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Moral criminality and its prevention
Janů, Veronika ; Bohuslav, Lukáš (advisor) ; Říha, Jiří (referee)
Moral criminality and its prevention Abstract The aim of the thesis dealing with moral criminality and its prevention is to provide a comprehensive overview of this type of crime. In particular, the thesis focuses on the impact of these crimes, which account for only 2% of the total registered crime in 2023, on the victim and presents questions on how best to protect the victim or prevent the crime from being committed. The thesis initially defines the basic concepts related to moral criminality. It also addresses the question of what morality is and how it affects the commission of sexually motivated crime. It then examines the legal regulation of moral criminality within the Czech legal system, with an emphasis on Act No. 40/2009 Coll., the Criminal Code. Within the framework of international regulation, it covers a range of international institutions, focusing mainly on documents of the United Nations, the European Union and the Council of Europe related to moral criminality. A large part of this chapter is devoted to the issue of ratification of the Council of Europe Convention on Preventing and Combating Violence Against Women and Domestic Violence, also known as the Istanbul Convention. The fourth to sixth chapters analyse in more detail the individual offences falling under the heading of moral...
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Representation in International Organizations: Size and Composition of National Delegations
Vlček, Václav ; Parízek, Michal (advisor) ; Karlas, Jan (referee) ; Sommerer, Thomas (referee)
In general, states and their governments make decisions in international politics and international organizations. However, the states are, in fact, represented by people. How many and who are they? This dissertation thesis deals with state representation in international organizations. In particular, it studies the size and composition of national delegations to plenary meetings of international organizations. From the theoretical perspective, the thesis builds on rationalist assumptions and tests established theories in the field. As for the causes of the various delegation sizes, the thesis hypothesizes 1) various institutional power, 2) different economic resources, 3) various intensity of national interests, 4) different levels of government effectiveness, and 5) different domestic political regimes. Next, the theoretical framework explains the various delegation composition by 1) different intensity of the national preferences, 2) different levels of government effectiveness, and 3) different domestic political regimes. From the methodological perspective, the thesis builds on an extensive statistical analysis using a unique quantitative dataset across seventeen international organizations and the UN General Assembly sessions from 1993 to 2016. The delegation composition is operationalized in...
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Family of child with Kabuki synrome
Jarošová, Kateřina ; Mužáková, Monika (advisor) ; Bartoňová, Miroslava (referee)
The thesis is about a family of a child with Kabuki syndrome. The first chapter deals with the syndrome itself, diagnosis, clinical symptoms and cognitive functions. The second chapter describes the family with the rare condition, the family in the context of the history and what stages the family of the child with the rare condition goes through. The next chapter discusses support for the family with a rare disease, and also includes the concept of a non-profit organization and an association. The practical section explores the family of an individual with Kabuki syndrome, and includes an interview with a family member. The research section is supplemented with a case study.
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Architectural and technological project of residential house Ždírec
Šimonová, Aneta ; Kolečkářová, Barbara (referee) ; Kantová, Radka (advisor)
Subject of the master's thesis is project planning and management of construction of apartment building in Ždírci nad Doubravou. There is prepared a technical report on the structural and technological project, situation with broder relations roadways, time and financial plan, studies the implementation of major technological stages, project construction site, design of building machines and mechanisms, plan for securing materiál resources, technological regulation for contact thermal insulation system, inspection and test plans contact thermal insulation system, budget of the main object, network graph of the construction process.
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Concept for Organizational Culture Change in a Company
Kroupová, Hana ; Čerbák, Jan (referee) ; Konečná, Zdeňka (advisor)
Bachelor thesis treats about organizational culture in the firm XYZ, Ltd. On the basis of questionary is designated structure, elements and orientation of organizational culture of the firm. The emphasis of this work is judge current organizational culture. The goal of this work is suggestion of alternation of the organizational culture to improve the communication among leaders and employees and with it related supposed increasing efficienty of companies.
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Design and implementation of VoIP protocols tester
Polášek, Jakub ; Číka, Petr (referee) ; Krajsa, Ondřej (advisor)
This paper deals with ways and means of testing SIP or IAX2 based equipment and protocols itselfs. I analyse terminology and methodology for benchmarking of proxy and registrar servers as it was described in documents RFC 7501 and RFC 7502 from organization IETF. In the practical part is described the tester realization programmed in PHP programming language witch will use described methodology. Aplication is available in web based interface.
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Statistical Analysis of an Organization´s Economic Risk Factors
Ambrožová, Andrea ; Sylva, Šujanová (referee) ; Karpíšek, Zdeněk (advisor)
This thesis deals with the evaluation of high-risk economical factors of one particular organization and consequently with their evaluation based on statistical methods. The principal aim of the study was to determine the dominant economic indicators of the organization and assess their development over time based on statistical methods, using statistical tools. The tools utilized in the thesis were Statgraphics Centurion XV and MS Excel.
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Maintenance organization of helicopters Ronbinson R22 and R44
Misík, Milan ; Hammer, Jaromír (referee) ; Chlebek, Jiří (advisor)
This bachelor thesis deals with organization for the maintenance of helicopters Robinson R22 and R44 including the certification of the staff. The introductory part is devoted to the managers of the organization and their responsibilities. The next section includes types of technical inspections and maintenance procedures. Subsequently, the work they handle and the issue of the quality system of the organization. The following chapter is about gaining experience and training which is necessary to obtain and become a certified maintenance technician. The last chapter focuses on purchasing new helicopters as well as transferring them to the Czech Republic and constructing them in the service center. This thesis does not serve as a guide to obtain an authorization from the organization for maintenance, but it serves as help for any individual interested in the field of aviation by clarifying the operation and process of the entire organization.
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