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Pharmacological approach to the results of the estrogen and progesterone receptors in the breast tumours.
Bařinková, Vlasta ; Hochmann, Jiří (advisor) ; Bunček, Martin (referee)
In the part devoted to discussion of different authors about the importance of the progesterone receptor (PR) value we concentrated primarily to the works of foreign authors published in professional journals. We divided the opinions of this experts to such, which show that PR testing is needless and to the part about profitability of this testing. In the chapter about importance PR testing some authors critize, that some patients - negative in estrogen receptors (ER) (such of them that are simultaneously PRpositive) could be deprived in the possibility of hormonal therapy, because PR testing wouldn't be made. And in the addition, the other - (in this case) the less effective treatment would be given them preferentially. PR testing is important also for detection of the group of ER-positive tumors with PR negativity. At this group is the smaller possibility that the tumors would respond to the hormonal treatment (in contrast to ER+/PR+). In the part devoted to gene therapy we described first the information about learning from the textbooks. Futher we describe different modes of classification of the gene therapy of the breast cancer in the foreign literature. We modified their classification further according to our necessity to these subheads: (1) mutation compensation of differentiation genes,...
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The Influence of Elicitation on the Production of Suspension Culture of Trifolium pratense L.
Keřková, Adéla ; Kašparová, Marie (advisor) ; Siatka, Tomáš (referee)
Adéla Keřková The Influence of Elicitation on the Production of Suspension Culture of Trifolium pratense L. Summary The paper examined the effect of four concentrations of cadmium chloride on the production of flavonoids and isoflavonoids by the Trifolium pratense L. suspension culture (variety DO-9 and SPRINT). The cultures were cultivated in the Gamborg nutrient media with the addition of 2 mg.l-1 of 2,4-dichlorophenoxyacetic acid and 2 mg.l-1 of 6-benzylaminopurine, at the temperature of 25 o C, 16-hr light/ 8-hr dark period. The elicited and the inspection samples underwent the photometric determination of flavonoids in accordance with the Czech Pharmacopoeia 2005 and the determination of flavonoids via the HPLC metod. The results show that the optimal effect of cadmium chloride on the production of flavonoids and isoflavonoids was manifestated after a 168-hour application of a concentration 0,1µmol (variety DO-9) and after 6-hour application (variety SPRINT).
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Comparison of european banks profitability
Šebor, Jan ; Dvořák, Petr (advisor) ; Tuček, Miroslav (referee)
The aim of this paper is to determine, whether the conclusions reached by some authors about the influence of the development of the financial system, bank size and taxation on bank profitability are also applicable to the European banking sector. This thesis is divided into 4 thematic parts. The first part tries to summarize the recent events that have had influence on the European banking sector as well as on the whole world and sum up their possible impact on bank profitability. A lot of attention is paid to the events of 2007 and 2008. The second and third subsection describes the basic theory, on which the thesis is build on. The balance and income statement is analysed in short as well. Further, an insight into the profitability ratios is given, because the comparison of these ratios is the centre of this paper. The forth, methodological, subsection and the fifth as well are focusing on the process contiguous our comparison. The data selection process and the influences on it are described in this section. The section also includes the fundamental base and hypotheses. The profitability comparison can be found in the next three subsections. The banks are not looked at as individual institutions, but there are concentrated into bigger units, based on country of residence and size. The last section deals with the influence of taxation on bank's profitability. The conclusion is dedicated to a summary of all the findings that were discovered during the previous sections.
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Abiotic elicitation of explant culture of Trifolium pratense L.
Fiedlerová, Gabriela ; Siatka, Tomáš (referee) ; Kašparová, Marie (advisor)
Abiotic elicitation of explant culture of Trifolium pratense L. Summary The objective of this dissertation was to observe the effect of the abiotic elicitors of mercuric chloride and cadmium chloride on the production of flavonoids, and also of the effect of the mercuric chloride elicitor on the production of isoflavonoids in the Trifolium pratense L. explant culture (variety DO−8). The cultures were cultivated in the Gamborg nutrient media with the addition of 2,4−dichlorphenoxyacetic acid (2 mg.l-1 ) and 6−benzylaminopurine (2 mg.l-1 ), in the temperature of 25 řC and during a 16-hours light/8-hours dark period. The quantity of flavonoids was determined spectrophotometrically according to The Czech Pharmacopoeia 2005. The quantity of isoflavonoids was determined by the HPLC method. We can see from the results of this dissertation that the concentration 10 μmol of both of the used abiotic elicitors had the greatest positive effect on the production of flavonoids. The largest quantity of flavonoids (0,576 %) was detected during the elicitation of cadmium chloride of a 10-μmol concentration and after 48−hour application when the quantity of flavonoids increased by statistically significant 294 % in relation to the control sample. The quantity of isoflavonoids was determined by the HPLC method during the...
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The Production of Secondary Metabolites in the Trifolium Pratense L. Suspension Culture
Zdražilová, Lenka ; Siatka, Tomáš (referee) ; Kašparová, Marie (advisor)
Lenka Zdražilová The production of secondary metabolites in the Trifolium pratense L. suspension culture Summary Elicitation is a method making use of protective mechanisms of plants to increase the production of secondary metabolites in plants and cultures in vitro. Jasmonic acid we can include into biotic elicitors, because it acts in plants as an inducer of the expression of protective proteins. In the experiment examined the impact of four concentrations of jasmonic acid and the impact of jasmonic acid in combination with calcium ions and verapamil on the production of flavonoids and isoflavonoids by the Trifolium pratense L. suspension culture (variety Sprint). The culture was cultivated in Gamborg medium to which 2 mg.l-1 of 2,4- dichlorophenoxyacetic acid and 2 mg.l-1 of 6-benzylaminopurine were added, at the temperature of 25řC, 16-hr light/8-hr dark period. The elicited and the inspection samples underwent the photometric determination of flavonoids in accordance with the Czech Pharmacopoeia 2009 and the determination of isoflavonoids via the HPLC method. The results show that the optimal effect of jasmonic acid on the production of flavonoids and isoflavonoids was manifested after a 24-hour application of the 50 µmol concentration. The stimulation of elicitation with extracellular calcium...
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In vitro cultures of medicinal of plants - VII
Machačková, Jana ; Martin, Jan (referee) ; Tůmová, Lenka (advisor)
In vitro cultures of medicinal of plants - VII Elicitation is one of the methods that can be used to increase production or accumulation of secondary metabolites in explants cultures. There were used callus and suspensions cultures of Silybum marianum (L.) Gaertn. Derivate N-phenylpyrazin-2-carboxamid was used as abiotic elicitor in concentrations c1=1.159x10-3 mol/l, c2=1.159x10-4 mol/l and c3=1.159x10- 5 mol/l. The effect of elicitors on the production (flavonolignans of silymarin complex and flavonoid of taxifolin) was evaluated after 6, 12, 24, 48, 72 and 168 hours. Cultures were cultivated on Murashige and Skoog medium with addition 10 mg/ml α-naphtylacetic acid (α- NAA). HPLC method for analysis was used. The maximal content of flavonolignans was reached after elicitor application in concentration c2 after 168 h in callus culture (0,08%). However the highest content of silydianin was detected after application of elicitor in concentration c1 (0.11 %) in suspensions culture. The maximal content of flavonoid taxifolin was noted in of nutritient medium of suspensions cultures.
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The Reflexion of 2ND World War in Novels by Hana Andronikova, Radka Denemarkova and Magdalena Platzova (God {--} Death {--} Identity)
SLEPIČKOVÁ, Pavla
The dissertation Reflection of 2nd World War in Novels by Hana Andronikova, Radka Denemarkova and Magdalena Platzova treats ways of reflection of war events in prosaic works of female authors mentioned above. For analysis of literary texts there are marked out fundamental motives of God, death and identity. The first part of the work pays attention to thematic analysis of texts according to individual motives including their specifics from the point of view of gender studies. The aim of the second part is finding both {--} coincident and different features in author reflection of 2nd World War by comparing which concentrates on ways of work with chosen motives in all three novels.
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EFQM Model Excellence and possibilities of its use in a concrete company
Ivánek, Martin ; Lukšů, Vladimír (advisor) ; Dvořák, Jiří (referee)
In the theoretical part of this thesis TQM principles are described together with its pracitcal framework, EFQM Model Excellence. This model is briefly descriobed with the main focus on the possibilities of its use and its outcomes. Self assessment is the most used part of the model so, it is logical to deserve the most attention. In the practical part of the job, the self assessment method and process is applied to a selected company. The company is evaluated in every criterium of the Model and the main strengths and areas of improvement are analyzed. In the end, everything is summarized so that one can concentrate on the most important findings.
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The Application of the Standard ISO 10014 in the Chosen Organization
Karasová, Pavla ; Plášková, Alena (advisor) ; Černochová, Lenka (referee)
The thesis concentrates on the International Standard ISO 10014 - Quality management -Guidelines for realizing financial and economic benefits. In the thesis management principles and the simply methodology called PDCA are described. The thesis is focused on the priniple of process approach and nutually beneficial supplier relationship. These methods according to the Standard are applicated: Drum-Buffer-Rope within process approach and the graphical method of supplier rating, the zone control charts and the comprehensive supplier performance evaluation. The benefits from the effective application of these methods and tools are described.
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