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Adhesion Molecules and their Role in Model of Pathological Conditions
Pospíšilová, Naďa ; Semecký, Vladimír (advisor) ; Geršl, Vladimír (referee) ; Stingl, Josef (referee)
Souhrn/Summary 1 Atherosclerosis is one of the major causes of cardiovascular morbidity. This chronic inflammatory disease is characterized by endothelial dysfunction with accumulation of lipids, leukocytes, smooth muscle cells and extracellular matrix within the vessel intima. This process results in reducing of the vessel lumen that can lead to the obstruction of vessel blood flow. The initiation of atherogenic process is characterized by the alteration of endothelial function which is so-called endothelial dysfunction. The endothelial dysfunction is characterized by the expression of cell adhesion molecules and increased endothelial permeability for monocytes, T-cells and lipoproteins. This is beginning of "vicious"circle of atherosclerosis. On of the most important cell adhesion molecules participating in the beginning of atherogenesis are members of the immunoglobulin superfamily, VCAM-1 (vascular cell adhesion molekule-1), ICAM-1 (intracellular cell adhesion molekule-1) and PECAM-1 (platelet-endothelial cell adhesion molekule-1).VCAM-1 and ICAM-1 are transmembrane glycoproteins participacing predominantly in the stabilization leukocyte of interaction with endothelium and transmigration of leukocytes into vessel intima. In this dissertation thesis, the first studies were focused on the endothelial...
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Fathers of children with multiple disabilities: coping with demanding life situation
Skryjová, Hana ; Kněžková, Kateřina (referee) ; Strnadová, Iva (advisor)
The thesis deal with fathers' endurance and their perception of having a child with multiple disabilities. The object of the work was to get the fathers' subjective view and internal perception of their special and demanding situation.. Introductory part concerns with theoretical bases on families and children with multiple disabilities. The multiple disabilities is explained in the first chapter. Etiological factors in the beginning of the multiple disabilities and its categorization. Second chapter deals with families of children with multiple disabilities and its phases between the first expressions of the disability and the affirmation of the diagnosis. The next chapter outlines development of the father's roles and his perception of the child's disabilities. Stressing factors in the families of children with multiple disabilities are the four chapter's content. Last chapter of this part inspects defensive stategies, evasive tactics, and the ways of coping with demanding life situations and endurance. The results of the qualitative investigation are described in the research part. First, methods, that were used, are described, objects of the search are set. To fulfill the aims of the work the author used a method of a semistructured inquiry. Twelve fathers took part. Analysis of the results are given in...
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The economic development of Zimbabwe from the year 1980 to the present
Lisá, Andrea ; Němečková, Tereza (advisor) ; Kašpar, Václav (referee)
The thesis is concerned with the economic development of Zimbabwe from its proclamation of independence in the year 1980 to the present. It is divided into single decades where it expresses economical and non-economical factors which influenced Zimbabwe. At the same time it is explaining the impact of these factors on the economy and standards of living. At the beginning of its independence Zimbabwe had good conditions for its future development. Through the years the Zimbabwean government has taken several measures and adopted some decisions, which determined the future development of this country. At the same time there were other factors which influenced the development of Zimbabwe. Essential was the issue of social dualism in the society, which was not settled until the year 2000. In 2000 land reform was started in order to remove the dualism, but it had a catastrophic impact on Zimbabwe. Another important factor analyzed in this thesis is for example the Economic Structural Adjustment Program from the 90ties. The thesis is also focused on macroeconomic indicators that fall behind through the years and it explains the reason for their downfall. The whole thesis shows the reasons that made once a country with a good position compared to other countries of Sub-Saharan Africa to a country facing miserable conditions today.
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Calculation of a Transfer Price of the Individual Operations in a chosen Firm
Štěpánková, Iva ; Stejskalová, Irena (advisor) ; Tyráček, Petr (referee)
Calculation of transfer prices of the individual performance means the calculation of the price of a product, service, work or other kind, expressed unit of output. Kind is usually expressed in the unit such as hours, kolograms, etc. The transfer price is a toll that is used for performance appraisals for the centers but is also used for other awards such as repair services, etc. This price is determined on the basis of precalculation. In the precalculation are listed the estimated cost of the product and the calculation shall be drawn up before the start of production, repectively at the beginning of the period. Individual performance is generally defined as the results of operations and as an external performance and internal performance. External performance are services such as goods, services or goods that are sold to consumers in the market at market prices. Internal performance are those services that are transmitted in particular within the enterprise between departments.
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Akis Pavlou - Music Composer and Teacher
Hadjivassiliou, Michalis ; Pecháček, Stanislav (advisor) ; Kittnarová, Olga (referee)
I would like to take this opportunity to express my gratitude and thanks to the people who have always been there for me and who influenced my life in so many ways. First of all, I am greatly indebted to my supervisor Doc. PhDr. Stanislav Pecháček. 1 would like to express my deep appreciation for all his invaluable support, encouragement, guidance, help and advice throughout the five years 1 have known him as student in the Charles University, Faculty of Education, in Prague, Czech Republic. As I have this opportunity 1 wish to thank my teacher Akis Pavlou for his time discussing with me all the topics which are included in this dissertation. I owe him a huge "thank you" not only for giving me the opportunity to work with him for this dissertation but also for all he has taught me, his precious encouragement and his endless invaluable emotional support during the 16 years I have known him as his student. 1 cannot forget, of course, the persons who entirely support me from the very beginning of my studies and even more when 1 started writing this dissertation. 1 am particularly indebted to my sister Angela and my brother-in-law Chris Zillman for their assistance and editing services. Their help is gratefully acknowledged.
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The Use of Metohods of the Project Management in Company
Došek, Ivan ; Holeš, Štefan (referee) ; Smolíková, Lenka (advisor)
The master´s thesis is about creating of travel blog. In the beginning there is analysis of actual situation and creating of change. Right after will be created risk analysis to see and identify risk and in case to express and stand in front of risk regarding their risk seriousness. Blog asi t is will be created with help of tools of project management and it should be transformed to small business in selling of cheap flights through the business partner.
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The role of glucocorticoids in circadian system
Tejkal, Karel ; Sumová, Alena (advisor) ; Forman, Martin (referee)
Glucocorticoids are mammalian steroid hormones secreted from the adrenal gland. The basal levels of glucocorticoids show a pronounced diurnal rhythm with maximum at the beginning of the active period and minimum at its end. Glucocorticoids have an influence over a variety of metabolic functions and their secretion is tightly regulated. This regulation also depends on the circadian system, which utilizes glucocorticoids to entrain the peripheral tissues by inducing rhythmic gene expression. The mechanisms by which glucocorticoids influence mammalian circadian system has not yet been precisely defined, especially concerning the influence of glucocorticoid signalling on gene expression in different tissues and the dynamics of glucocorticoid receptor (GR) occupancy. This thesis studies the influence of ablation of glucocorticoid signalization induced by adrenalectomy on the clock gene expression of in the central clock in the suprachiasmatic nucleus and peripheral clocks in the hippocampus and distal colon. The effect of adrenalectomy on gene expression is compared with the effect of restricting the feeding time, which has also been shown to affect glucocorticoid levels in the body. Other experiments were aimed at elucidating impact of changing the activity of GR on gene expression using synthetic GR...
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Transfer and interpretation. Expatriation of Czechoslovak citizens of German birth 1945-1947 and its accounts in daily newspaper
Klimeš, David ; Bednařík, Petr (referee) ; Kubů, Eduard (advisor)
The aim of my thesis is to analyze the transfer of the Gennan people as covered by the daily press, which was both partisian and officially considered not to be under the influence of the political parties. Among such newspapers were Právo lidu, Svobodné Slovo, Rudé právo, Lidová demokracie, Svobodné noviny, Práce, Zemědělsé noviny, Svobodné československo (Obrana lidu), Mladá fronta and Národní osvobození. In fact, most of these "independent" newspapers were under control of the Communist Party. Resettlement of the Germans was one of the most important issues discussed by the Czech cabinet after the W orld War II. The transfer of the Gennans was obviousl y a genuine wish of the maj ority of the Czech people. However, following the first revolutionary months, a variety of opinions was being expressed on this issue. The Communists wanted to use the resettlement as a political instrument. Naturally, they were in favor of a total transfer of the Germans. On the other hand, other political powers expressed more moderate views, such as the catholic People's Party. The debate was broadly covered by the newspapaers. The media offered greater variety of perspective. There was a strong censorship by the establishment as well as by the journalists themselves, and no one dared to stand against the Košický program...
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The accounting reform of municipalities, valid since 2010
Andělová, Martina ; Takáčová, Hana (advisor) ; Nováková, Štěpánka (referee)
This bachelor thesis deals with the accounting reform of the state and focuses on municipalities and the depreciation of their fixed assets. At the beginning, there are basic characteristics of municipalities, then there is mentioned accounting before the reform. This accounting was focused on the cash principle of accounting and fixed assets. Another part deals with changes in the accounting including aims of the reform. It describes the principle of accrual accounting, changes in the chart of accounts. This part is specialized in fixed assets and depreciation methods. The last part compares the accounting before the reform and after the reform. The differences are expressed by examples of fixed assets.
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Changes in the behavior of children in a group of school clubs the careful application of effective communication
SOLDÁTOVÁ, Jana
The thesis deals with the instrumentality of usage efficient communication and prosocial activities on primary children´s behaviour in class after-school club. The observed areas are coping, solving plus percent occurrence of conflicts, mutual communication together with the expression of personal opinions. Furthermore, the work compared the atmosphere within the class after-school club before the research in January 2014 and after its completion in June 2014. The results of the empirical investigation of quantitative research are compared with each other at the beginning as well as at the end of the research. These outcomes were compared with the results of the control group. They prove that the change of educational approach by using the effective communication and prosocial activities can affect children's behavior.
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