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Endocrine function of adipose tissue and its role in development of atherosclerosis.
Bošanská, Lenka ; Haluzík, Martin (advisor) ; Vokurka, Martin (referee) ; Kříž, Jan (referee)
Adipose tissue represents a multi-functional endocrine organ. Obesity may lead to the increased release of proinflammatory factors and adhesion molecules from adipose tissue, thus playing an important role in the development of atherosclerosis. Recent research studies were focused on the mechanisms of the endothelial dysfunction, low-grade inflammation and adipose tissue endocrine function dysregulation, and their mutual relationships. These processes are of a great interest due to their clinical relevance and increasing numbers of patients suffering from cardiovascular diseases or being at high risk of early atherosclerosis progression. Exact mechanisms and interrelationships of these factors are yet to be fully clarified. (...) Results of this project may represent another step on the way to the detailed explanation of the mechanisms and relationships between adipose tissue endocrine function or dysfunction and atherosclerosis development. Better understanding and ability to prevent or treat the negative metabolic effects of adipose tissue-derived molecules would be of great importance for numbers of patients at high risk of cardiovascular diseases.
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New trends in marketing communication
Khalilova, Nazila ; Štědroň, Bohumír (advisor) ; Procházka, Jan (referee)
The bachelor thesis "New trends in marketing communication" focuses on the new methods in a communication mix, such as guerilla, buzz, mobile, direct and event marketing, and product placement. The primary goal of the thesis is to define these tools and show the importance of implementing these methods in a globalised world. Samples of implementations of these new tools are shown on both, the Azerbaijanian and world market, in the practical part of the thesis. Also, Azerbaijanian market is shown as a potential market for the foreign investors.
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Lower urinary tract dysfunctions in patients with diabetes mellitus
Osdal, Arnfinn ; Zachoval, Roman (advisor)
Diabetes mellitus (DM) is a endocrine metabolic disorder that is associated with many complications and lower urinary tract dysfunction (LUTD) is one of them. In addition LUTD can be caused by many other disorders and sometimes it can be difficult to isolate the cause. Incidence of diabetes is increasing and prevalence is expected to increase worldwide to 300 million people in 2025. The most important causes for diabetes and lower urinary tract abnormalities are diabetic neuropathy caused by hyperglycaemia. Approximately 50% of diabetic patients develop some form of neuropathy. Diabetes can cause LUTD many ways and research have shown many possible mechanisms involved. Among the suggested mechanisms are up-regulation of muscarinic receptors, smooth muscle hypertrophy, increase in myosin light chain phosphorylation and changes of certain calcium sensitive potassiumchannels (MaxiK). The increasing knowledge of pathophysiology and pathogenesis of LUTD made it necessary with a new approach to patients, terminology changes, better definitions and classifications. Among the contributors is European urologic association (EUA). The importance of preventive measures and good treatment in diabetes can not be underestimated. Their role has an increasing importance today and for the future because of its negative...
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Molecular mechanisms of checkpoint signalling and termination
Benada, Jan ; Macůrek, Libor (advisor) ; Brábek, Jan (referee) ; Truksa, Jaroslav (referee)
Cells employ an extensive signalling network to protect their genome integrity, termed DNA damage response (DDR). The DDR can trigger cell cycle checkpoints which prevent cell cycle progression and allow repair of DNA damage. The failures in these safeguarding mechanism are represented by serious human malignancies, most predominantly by cancer development. This work aims to contribute to the understanding of how do the cells negatively regulate DDR and cell cycle checkpoint signalling. We focused mainly on Wip1 (PPM1D) phosphatase, which is a major negative regulator of DDR and is indispensable for checkpoint recovery. Firstly, we have shown that Wip1 is degraded during mitosis in APC-Cdc20 dependent manner. Moreover, Wip1 is phosphorylated at multiple residues during mitosis, resulting in inhibition of its enzymatic activity. We suggest that the abrogation of Wip1 activity enables cells to react adequately even to low levels of DNA damage encountered during unperturbed mitosis. In the following publication, we have investigated why the mitotic cells trigger only early events of DDR and do not proceed to the recruitment of DNA repair factors such as 53BP1. We showed that 53BP1 is phosphorylated within its ubiquitination-dependent recruitment domain by CDK1 and Plk1. These phosphorylations prevents...
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Contribution to economic and policy evaluation of implementation eHeatlh solutions into health services
Rozmarinová, Jana ; Petrášek, František (advisor) ; Kučerová, Jaroslava (referee)
This thesis is dealing with problems of eHealth specified on particular conditions on the territory of the Czech Republic in context of national economy. Positive and negative aspects of implementation of eHealth solution into health services is evaluated in theoretic part of thesis as well as dominative problems which faces development of eHealth in the Czech Republic. Fundamental plans of support eHealth in the European Union and Czech Republic are described as well. Practical part of thesis is concerned with particular projects of eHealth in the Czech republic. Evaluation of project IZIP is performed due to questionnaire inquiry among the doctors. The example of contribution of implementation eHealth solution into health services is shown on Oblastní nemocnice Mladá Boleslav, a.s.
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Management of sporting events - 6 Nations
Ulrichová, Kateřina ; Voráček, Josef (advisor) ; Crossan, William Morea (referee)
Title: Management of sporting event - 6 Nations Objectives: Target of the thesis is brought and defines problems with organization sport action 6 Nations. Whole organization will be describe and next will be analyzed the problems, with which the organizers had the opportunity to meet. With help of selected theoretic method will be on the conception of the project the next year show, how prevent and eliminate the arising situation so as the negative repercussion was least. The most important chapter is propagation of the action and options, that this part was the best result. Methods: With help of descriptive case study and date analysis of case study will be description organization of whole action that will be analyzed. On a questionnaire and discussion will be shown problems with propagation and will be devise the methods of propagation so as the propagations was the most intensive and reach target groups. In conclusion is done generalization the obtained results and setting assumptions to successful organization of sport enterprise. Results: Have been identified deficiencies in quality of propagation that wasn't focused on ideal target groups and thus not be met, which was set before the event. The main purpose was expand the water polo between people and get to water polo another young active...
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Determinants of Industrialization in sub-Saharan Africa and Possibilities for their Development
Sejkora, Jiří ; Jiránková, Martina (advisor) ; Šaroch, Stanislav (referee) ; Fárek, Jiří (referee) ; Adamcová, Lenka (referee)
Sub-Saharan economies need structural changes that would enhance their productivity, increase economic growth and development. In this regard, industrialization plays a key role. Using regression analysis, the aim of this dissertation thesis is to identify main factors (determinants) of industrialization in sub-Saharan Africa. The results indicate that infrastructure and economy size (measured by population size) represent main determinants of industrialization in the region. The thesis also deals with possibilities for development of those determinants. Case study of infrastructure development in Mauritius emphasizes privatization, cooperation with external subjects etc. Negative consequences of small economy size can be overcome by preferential trade agreements (under certain circumstances), as shown by analysis of the three smallest economies in the region.
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Motivating and mobilizing elements in music activities of children
Kautská, Klára ; Váňová, Hana (advisor) ; Kodejška, Miloš (referee)
The topic of my bachelor essay is an inventory of motivational and activating elements/components in music activities for chlidren at preschool age. The theoretical part deals with motivation and activity in general.lt defines basicconcepts such as motivation,motive,motivation on music akactivities, activity, activation, and activating level relating to preschool education. These elements are shown in practice in the second part where the efíectivenessoťthe chosen motivational and activating elements is verified. Powered by TCPDF (www.tcpdf.org)
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The impact of motherhood on retirement benefits
Šatava, Jiří
In our analysis, we have attempted to quantify the negative impact of motherhood and parenthood on women’s retirement benefit amount, which is linked to the impact of motherhood on the mothers’ wages and employment. We have calculated that motherhood and parenthood reduces women’s retirement benefits by an average of several hundred Czech crowns per month. This is caused both by lower employment and lower earnings due to parenthood. However, the average reduction in women’s retirement benefits due to parenthood never exceeds 8 percent, even if the impact of parenthood on women’s career were twice that shown in the data.
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Effect of the exchange rate CZK on the amount of revenues from toll and time-toll systems on the roads in the Czech Republic
Raštica, Marek ; Stroukal, Dominik (advisor) ; Potužák, Pavel (referee)
This thesis examines the impact of the real exchange rate on the amount of revenues from a system of tolled and time tolled roads in the Czech Republic in the years 1999-2014. This effect is investigated on monthly data using regression analysis on two systems of tolled roads separately, system of tolled roads and system of time-tolled roads. Based on available dataset was shown a statistically significant negative effect of the real exchange rate on toll revenues in the system of tolled roads. In the case of time-tolled roads system was demonstrated negative effect of real exchange rate on time-toll revenues, but this effect is questionable, since the influence has been demonstrated only in a model with limited explanatory power.
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