|
Yeast as a tool in development of new antivirals
Dubská, Jitka ; Janderová, Blanka (referee) ; Mašek, Tomáš (advisor)
The increase of infectious chronic diseases is the main health problem of modern civilization. These diseases, which are spread both in developing as well as industrial countries, cause more than 59% of all life ends. Statistically, the most frequent infection is hepatitis C virus (HCV) infection. Incurable hepatic illnesses such as cirrhosis and hepatocellular carcinoma are the outcomes of the HCV infection and the liver transplantation is the only successful therapeutic option for the patients in industrial countries. It is estimated that about 170 million people worldwide are chronically infected with this virus. HCV is a small coated virus with single stranded RNA genome of positive polarity. Lots of research has been done since it was discovered twenty years ago but the efficient drug is still missing. There is a strong tendency to focus the research on searching for translation initiation inhibitors in last few years, because the whole life cycle of HCV, including RNA replication, new virions assembly etc., is dependent on translation products. Nowadays there is a small group of human proteins (so called ITAFs) known for up- or down-regulate HCV and other viruses translation initiation. It is believed, that this group is much more comprehensive. The aim of this diploma work was to construct yeast...
|
|
"Art" and its definition. Between function and procedure
Ciporanov, Denis ; Kulka, Tomáš (advisor) ; Haman, Aleš (referee) ; Zuska, Vlastimil (referee)
The thesis explores the problem of definition of "art" as it has been systematically discussed since the second half of the 20th century - mainly in the Anglo-American analytical aesthetic tradition. Despite the complexity and diversity of this discussion, it is possible to indicate two opposite definitional approaches. The first is the so called proceduralism which is established on the conviction, that the art status is connected with certain performative procedures (social, theoretical or historical in character), and that its attribution to an artifact essentially affects its artistic/aesthetic function. The second is a functional strategy, traditional in character, which presupposes on the contrary, that ascription of art status comes always after the indication of functional efficiency of the artifact in question. In four parts of this thesis we want to argue for the superiority of functional view of the concept of art. To do that, we made one exceptional step out of the borders of analytical tradition in order to see how this traditional problem is solved in the theoretical context of Prague Structuralistic School, domain of European functional thinking. The comparison of Jan Mukařovský, the main representative of functional approach to art, with Nelson Goodman, one of the most prominent American...
|
|
The ability of new firms to enter the monopolistic enviroment
Diblík, Petr ; Ježek, Tomáš (advisor) ; Dočkal, Dalibor (referee)
The present thesis deals with topic of monopolies and ability of new entities to enter mar-kets where such monopoly is present. For a deeper understanding of this field various views on monopolies in history of economic thinking are mentioned in introduction. In connection with possibility of new companies establishing themselves on the market there is analyzed creation and current practice of anti-monopoly legislation. In this part, certain arguments favoring protectionist policies are impugned. On particular examples it is dem-onstrated that more than privileges from the part of the state it is ensuring of free access to a given field which helps to a starting company. The state should be a guarantor of law enforcement and oversee observation of generally binging rules. In the conclusion of the work a difference is also shown between a situation where a monopoly originates in a natu-ral way as a result of exceptionality, which the clients positively value and a monopoly which exists due to support by state. A new company, as a continuous potential competitor, presents a good-quality feedback for a dominant entity and a driving engine for enhancing its efficiency. A free economic competition is shown also here as an effective tool for de-velopment of business, and it is the consumer who derives major benefits from such situa-tion.
|
|
Bone metabolism, infection and ischemia in diabetic foot syndrome
Bém, Robert ; Jirkovská, Alexandra (advisor) ; Štěpán, Jan (referee) ; Broulík, Petr (referee)
The diabetic foot (DF) is one of the most frequent late complications of diabetes, which often leads to limb amputation and effects the quality of life in patients with diabetes. Ischaemia and infection play important role in pathogenesis of DF. One form of DF is Charcot neuroosteoarthropathy (CNO), defined as a noninfectious destruction of bones and joints in the foot due to diabetic neuropathy. The subject of the dissertation thesis was divided into 3 parts: bone metabolism and CNO, ischaemia and infection in DF and new methods in the treatment of DF. (...) In the third study, new quantitative scintigraphic parameters for assessment of CNO activity were defined and confirmed their satisfactory correlation with other parameters of CNO activity. In fourth and fifth study,good reproducibility was verified and efficiency of power spectral analysis of heart rate variability as a new method for diagnosis of autonomic neuropathy in patients with CNO. Sixth study refered to rare causes of atypical localization of CNO in the knee joint. Ischaemia and infection in DF were resolved in one study. In multivariate analysis of seventh study we approved, that risk factors for difficulty healing after minor amputation of the foot were low level of transcutaneous oxygen tension and high level of C-reactive protein before...
|
|
Project management
Jon, Jakub ; Řepa, Václav (advisor) ; Lacko, Branislav (referee)
Every part of human life is experiencing constant development. Turning point of modern company competition is the ability to react to changes and needs of environment. This precondition is mainly for filled through projects. This thesis focused on project management analysis of employee component and impact of his satisfaction on project efficiency. These findings are the ground of the discovery of substantial factors (such as mood in organization, awareness, evaluation etc.), which affects projects run. Each factor has assigned group of measures in order to enhance project management capability of common company. Within analysis, basic dispositions for project environment, in which are projects realised, were identified and this led to derivation of project environment maturity model. Model should force company to think about quality of current environment and be a guideline to further improvement.
|
|
The implementation of the information system at the travel agency
Šanda, Vladimír ; Lorenc, Miroslav (advisor) ; Švecová, Lenka (referee)
This Bachelor thesis explores criteria for choosing an information system and its subsequent implementation in a company. It introduces us with the real information system M2G which is used by travel agencies. It offers comparison with competing businesses and thinks of principal assets and weaknesses of the system which lead to acceptance or refusal system M2G in competitive tendering of travel agencies. The thesis analyses the process of the implementation, describes and evaluates the use of the project management. The main objective of this thesis is, on the basis of theoretical knowledge, discover imperfections of the project management in the supplier's company and make suggestions which could lead to more efficient implementation of the information system. Another objective is to compose steps contributing to higher success in selling the system. So the thesis suggests internal changes and changes pointed to customers.
|
|
Systemic psychotherapy in theory and practice on becoming a psychotherapist
Novotná, Nora ; Junková, Vendula (referee) ; Štětovská, Iva (advisor)
The thesis investigates the process of becoming a psychotherapist in the context of systemic therapy. It outlines philosophical and psychotherapeutic roots of the systemic approach, emphasizing postmodern thinking, in particular poststructuralism, radical and social constructivism and modern biological gnoseology. The work discusses theoretical foundations as well as practical applications of the teaching of the Prague Institute for Systemic Therapy (IST). It covers five main lines of thoughts in systemic thinking - the Milan school of family therapy, strategic therapy by Milton Erickson, brief solution-focused therapy (BSFT), Hamburg school and the narrative approach. The work focuses on defining and delineating the role of the therapist and the client, and their cooperation in the therapeutic dialogue. It emphasizes therapist's self-reflection during the therapeutic process as the primary way of influencing the client, and it discusses models which make the self-reflection more efficient. The art of dialogue is presented as the fundamental skill of a systemic therapist. Last but not least, the work covers an important area of systemic ethics and supervision. The empirical part of the work investigates, using the qualitative based interview, the process of becoming a therapist on a sample of 19...
|
|
The informed consent of a patient
Semrád, Václav ; Císařová, Dagmar (advisor) ; Sovová, Olga (referee)
58 Informed Consent of Patient 8 Summary Informed consent of patient is as a legal concept excercised in health service on daily basis. Its importance for consumers of medical services oscillates from trivial act that does not require any special attention to crucial decisions, that shall determine further period of patient's life. Significance of cosnent is given by nature of medical situation with which particular patient comes across. Current legal framework is based on both-international and national rules of law. The first are represented by International Convention218 that stipulates fundamental principles, the latter more specificaly elaborates further details of the whole concept. Consent on patient with medical intervention historicaly went through several stages. In the course of own developement was closely related to providing the patient with information. In ancient and medieval times was not usuall that physician informed his patient comprehensively. Means of treatment and their efficiency were rather limited and many diseases and injuries that recent medicine considers as curable lead often to fatal consquences. Maintenance of faith and resolution of patient to fight with adversity seemed to be crucial within such conditions. As a condition of medical intervention was consent introduced by...
|
|
Implementation of Lean Management Techniques in selected Organization
Žižková, Aneta ; Zelená, Veronika (advisor) ; Váchová, Lucie (referee)
The main objectives of the bachelor thesis are methods of lean management in the Japanese way. The theoretical part is mainly focused on the individual methods such as Kaizen, 5S and Kanban. The aim of this thesis is to realize what Japanese way of thinking actually is and how works in practice. In the practical part I will implement these methods in the most efficient way in the given company. The most important process is reduction of waste. The conclusion provides improvements and recommendations for the company.
|
|
Innovation policy of Israel
Křivová, Petra ; Müller, David (advisor) ; Bolotov, Ilya (referee)
The goal of this thesis is to understand the innovation policy of Israel and find recommendations for innovation policy of Czech republic. The first chapter aims to define basic theoretical concepts of innovation and measurements of the efficiency of innovation policy and competitiveness of the economy as such. The second chapter analyzes the innovation policy of Israel, its origins, the factors causing innovative thinking, the government tools for the support of innovation and successful innovation projects. The final chapter contains a comparison of the innovative aspects of the two countries, evaluation of cooperation and inspiration for the Czech innovation system based on my research.
|
guest ::
