Original title: Využití kvasinek ve vývoji nových antivirotik
Translated title: Yeast as a tool in development of new antivirals
Authors: Dubská, Jitka ; Janderová, Blanka (referee) ; Mašek, Tomáš (advisor)
Document type: Master’s theses
Year: 2009
Language: cze
Abstract: The increase of infectious chronic diseases is the main health problem of modern civilization. These diseases, which are spread both in developing as well as industrial countries, cause more than 59% of all life ends. Statistically, the most frequent infection is hepatitis C virus (HCV) infection. Incurable hepatic illnesses such as cirrhosis and hepatocellular carcinoma are the outcomes of the HCV infection and the liver transplantation is the only successful therapeutic option for the patients in industrial countries. It is estimated that about 170 million people worldwide are chronically infected with this virus. HCV is a small coated virus with single stranded RNA genome of positive polarity. Lots of research has been done since it was discovered twenty years ago but the efficient drug is still missing. There is a strong tendency to focus the research on searching for translation initiation inhibitors in last few years, because the whole life cycle of HCV, including RNA replication, new virions assembly etc., is dependent on translation products. Nowadays there is a small group of human proteins (so called ITAFs) known for up- or down-regulate HCV and other viruses translation initiation. It is believed, that this group is much more comprehensive. The aim of this diploma work was to construct yeast...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/26545

Permalink: http://www.nusl.cz/ntk/nusl-281634


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses