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Comprehensive child developmenz in preschool upbringing
Vlasáková, Kristýna ; Komárková, Tereza (advisor) ; Swoboda, Jaroslava (referee)
This bachelor thesis is comprehensively devoted to the entire preschool period. It primarily focuses on child development where all branches of development are described, always in relation to a specific age period. The interweaving of knowledge about development into other areas closely related to the profession of a kindergarten teacher is also included. A closer look at developmental areas can be much more useful than it might seem at first glance. It makes it possible to solve complex problems such as professional burnout or issues of appropriate motivation. It makes it possible to improve communication between all participants in the educational process. It helps all teachers in getting to know children and choosing a suitable educational approach. It helps teachers in choosing activities. Last but not least, it helps to understand the world through children's eyes, which is essential for all educators who want only happy children in kindergartens. This and much more can be read in this bachelor thesis. Key words: Kindergarten, development, preschool period, upbringing, education, school preparedness and readiness, communication, burnout, diagnosis, motivation, activities
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The importance of different sources and sequencing protocols in increasing the accuracy of NGS analysis in diagnostic applications
Kvapilová, Kateřina ; Kozmik, Zbyněk (advisor) ; Piherová, Lenka (referee) ; Slabý, Ondřej (referee)
1 ABSTRACT Continued advances in next-generation sequencing (NGS) technology, such as capacity, speed, and reduced cost per sequenced base, revolutionize personalized medicine and bring genomics into routine clinical practice. Nevertheless, NGS is still under rapid development, and the variability of sequencing protocols and validation procedures is one of its current bottlenecks. This thesis aimed to study the influence of different sample sources and NGS protocols (NGS library construction-sequencing-data analysis) on the accuracy of NGS analysis in diagnostic applications. In the first study, performed during the COVID-19 pandemic outbreak, we developed NGS protocols suitable for a whole genome analysis of the SARS-CoV-2 virus. Subsequently, in the second study, we examined the suitability of human saliva-derived gDNA for genomic/genetic analysis of selected variant types compared to traditional blood-derived gDNAusing validated NGS protocol and statistical comparison of the obtained data. Whole genome analysis of the SARS-CoV-2 genome was performed using two captured- based approaches and one amplicon-based approach to study the quality and effectivity of the respective NGS protocols. Synthetic controls were employed to verify the accuracy and specificity of the developed NGS protocols. We proved that...
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Germanisms in the novel The End of Punk in Helsinki by Jaroslav Rudiš
Müllerová, Michaela ; Vachková, Marie (advisor) ; Šemelík, Martin (referee)
This thesis analyzes the Germanisms in Rudiš's novel "The End of Punk in Helsinki". The aim is to describe the individual Germanisms in terms of their function in the text, their comprehensibility, and the subjective perception of their use in contemporary Czech. Subsequently, some Germanisms were also analyzed in the Czech language corpus InterCorp and SYN, whereby their frequency and the stylistic markers found in the dictionaries were verified. The analysis and the corpus research showed in most cases the correspondence of the stylistic markers found in the dictionaries with those in the novel or the corpus, as well as stylistic effects that, among others, contribute to a closer characterization of the speaker from the regional or social point of view.
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The vocabulary of Maghrebi French and its presence in "Le Petit Robert"
Musilová, Barbora ; Mudrochová, Radka (advisor) ; Nádvorníková, Olga (referee)
Le lexique du français maghrébin et sa présence dans Le Petit Robert Barbora Musilová Abstract This bachelor thesis focuses on the French language used in the Maghreb and the occurrence of its vocabulary in general dictionaries. The thesis shows the position of the French language in Francophone Africa with special emphasis on the Maghreb region. It reveals part of the history behind the emergence of the current situation of French in these places. The work also offers a comprehensive view of the position of the French language in relation to other languages used in Francophone parts of Africa. The practical part of this thesis maps the original expressions of Maghrebi French and their representation in the online version of the dictionary "Le Petit Robert". The list of expressions is accompanied by a detailed linguistic analysis. This analysis consists of the identification of the word type, the origin of the expression, the possible uses, the meaning and other possible parameters. The thesis also traces the occurrence of the vocabulary of Maghrebi French according to Jaromír Kadlec, who deals with it in several chapters of the book "Francouzština v Africe", in the online dictionary Le Petit Robert. The work also offers a comparison of these terms in various French language dictionaries.
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A church before the walls. The construction of the church of Corpus Christi and saint Barbara in Kutná Hora until 1556.
Czadera, Ondřej ; Bobková, Lenka (advisor) ; Pohanka, Viktor (referee)
The aim of this bachelor thesis is to convey the progression and concurrencies of the construction of the chapel of Corpus Christi and saint Barbra in Kutná Hora. To summarise the research of the topic and to describe the reasons for the construction and its problems in the context of the growing mining town of Kutná Hora. Then to describe the uniqueness of the foundation of Kutná Hora, its parochial administration, and the unique difficult relations with the monastery in Sedlec, the former landowners. Finally, by analysis of the surviving construction records, to reconstruct the economic structure of the construction, namely the structure of expenses and the sources of income of this quite expensive project. In that case, the thesis mainly uses the construction records and additionally select records from the city archival records. Keywords Kutná Hora, parochial administration, building accounts, saint Barbara's church, medieval construction
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Anglický název práce: Possibilities for solving behavioral and learning disorders in primary school
Brych, Denis ; Komárková, Tereza (advisor) ; Sedláčková, Daniela (referee)
Červený vrch primary school in Prague 6. It addresses the factors that influence the work of these children and the methods that can be used in practice. In the theoretical part of the thesis, it contains a definition of the terms behavioural and learning disorders, their causes, possibilities of re education including selected methods for working with these pupils. In the practical part of the thesis the focu aged from eight to twelve years. Interviews with children, parents, assistants and teachers were used in the research. In addition, the actual work with the pupils involved in the research. These met observation, interviews, working with pupils in the classroom, trying out the techniques described in the theoretical section and collaborative assessment. All in collaboration with teaching assistants and teachers. Their work in class, learning outcomes and behaviour during breaks were assessed. The main aim of the work was to find out the factors that influence the life of children with behavioural and learning disorders in primary school, or to try in practice different techniques for working with them. There is no doubt that there are many factors that affect the work and life of a child with behavioural or learning difficulties in a school environment. From the research conducted at the previously...
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Donations for the Hospital of Saint Francis "in pede pontis" of the Knights of the Cross with the Red Star in Prague during Reign of John of Luxemburg
Šteflová, Květa ; Bobková, Lenka (advisor) ; Zilynská, Blanka (referee)
This bachelor thesis is about donations for the Hospital of Saint Francis of the Knights of the Cross with the Red Star during Reign of John of Luxemburg. The thesis focuses on donation of queen Elisabeth, margrave Charles and especially of the king John. It tries to understand - based on the documents - the relationship between the hospital and the king, the amount of support, which was given to the hospital, as well as the formulations, which were used in the charts. For wider context the documents of the Přemyslovci dynasty are briefly mentioned, too. This thesis also describes current state of research and the literature, which attends to the topic.
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The effect of adjustment of sleep patterns on mental stress and body weight
Mutinský, Petr ; Manková, Denisa (advisor) ; Nekovářová, Tereza (referee)
This study aimed to investigate the impact of sleep pattern modification on sleep quality, circadian preference, mental strain, and body composition. Sleep pattern modification was implemented through a 14-day intervention involving three groups with varying levels of engagement. All participants received recommendations compiled into a sleep manual. The primary objective was to examine the relationship between sleep pattern modification and changes in sleep quality, circadian preference, stress levels, and body composition, including body fat and skeletal muscle mass. Additionally, the study sought to determine whether the level of engagement in sleep pattern modification within each group influenced post- intervention sleep quality. The study employed an online questionnaire battery comprising the PSQI, MEQ, and PSS-10 questionnaires, completed by N = 95 physically active participants aged 18-53 years. Body composition measurements were obtained using an InBody device. Repeated measures ANOVA analysis revealed a statistically significant improvement in sleep quality following the intervention as measured by the PSQI questionnaire (F(1, 77) = 144,31, p < 0,001, ηšₚ = 0,66). However, no significant interaction between the intervention and individual groups was found (F(2, 75) = 1,29, p = 0,28, ηšₚ...
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Unsupervised Cloud Classification of Sky Imagery
Piter, Oliver ; Šikudová, Elena (advisor) ; Rittig, Tobias (referee)
Cloud classification task is a task where we classify images of clouds into groups of similar images. Images are similar in terms of texture, shape, colour, size and other visual aspects. The aim of this work is to create an algorithm that can cluster images of clouds based on their sky coverage so that a user can request a specific type of cloud coverage from database of images and use the images for downstream tasks such as procedural sky generation. We use various models for feature extraction based on contrastive learning and image reconstruction and for clustering we use self-supervised learning and distance- based methods. These methods were used for clustering a subset of our data and evaluated based on visual consistency of clusters and cluster separation metrics. 1
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Repeated low-dose flubendazole treatment and its effect on glioblastoma cells
Namyslová, Marie ; Szotáková, Barbora (advisor) ; Králová, Věra (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Marie Namyslová Supervisor: prof. Ing. Barbora Szotáková, Ph.D. Title of diploma thesis: Repeated low-dose flubendazole treatment and its effect on glioblastoma cells Glioblastoma (GBM) is one of the most aggressive and common primary brain tumours in the adults. GBM is resistant to current treatment and the median survival of treated patients with this disease is around 15 months. The very poor prognosis of this disease has prompted the research of new therapeutic strategies. A promising direction is represented by drugs already registered for other indications, such as the anthelmintic flubendazole (FLU) with potential antitumour activity. The aim of this work was to study the effect of FLU after repeated low-dose treatment of GBM cells. Two cell lines, U87MG and U87MG-IDH1mut, were used for this work and the effect of repeated doses of FLU on cell viability (using the WST-1) and on cell morphology (via phase contrast microscopy) was investigated. Furthermore, changes in the expression of cell cycle markers, proliferation, growth, and resistance markers after FLU treatment were evaluated at the mRNA level (RT-PCR) and protein level (Western blotting). Subsequently, the activity of initiator and...
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