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Patients' attitudes to pharmacotherapy of osteoporosis
Theimerová, Hana ; Vytřísalová, Magda (advisor) ; Hendrychová, Tereza (referee)
1 ABSTRACT PATIENTS' ATTITUDES TO PHARMACOTHERAPY OF OSTEOPOROSIS Author: Hana Theimerová Supervisor: Magda Vytřísalová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy INTRODUCTION: Patients' attitudes to treatment might be affected by various factors. These may vary in different generations as well as in different populations. The patients' attitudes to the treatment along with the illness may affect decision concerning the beginning, interruption or end of the treatment. That implies that the interaction between these factors and attitudes to the treatment is comprehensive. AIMS: The study aim was to evaluate the patients' attitudes to the treatment of osteoporosis based on the perception of necessity and concerns of treatment with oral bisphosphonates (BIS). METHODS: Data for the analysis were obtained using an anonymous questionnaire in five outpatient centres in the Czech Republic from November 2012 to March 2013. The patients' opinions concerning the BIS treatment were identified (necessity vs. concerns) using the Czech version of the "Beliefs about Medicines Questionnaire Specific" (BMQ-CZ). RESULTS: A total of 363 patients were involved in the analysis (mean age 68.9 years). Patients were treated with once a week dosing forms of BIS -...
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Adherence to pharmacotherapy of osteoporosis
Santariová, Martina ; Vytřísalová, Magda (advisor) ; Doseděl, Martin (referee)
ADHERENCE TO PHARMACOTHERAPY OF OSTEOPOROSIS Author: Martina Santariová Supervisor: PharmDr. Magda Vytřísalová, Ph.D. Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy INTRODUCTION: Adherence is the extent to which the patient's behavior (using of medication, following recommended regimen) is in accordance with the advice of the health care provider. Adherence to pharmacotherapy of osteoporosis, including compliance and persistence, is still suboptimal. OBJECTIVE: The objective of the study was assessing of subjectively evaluated adherence with peroral bisphosphonates used to treat osteoporosis within Czech women. METHODS: A cross-sectional multicentre survey. Data collecting was carried out using anonymous questionnaire in five osteocenters in the Czech Republic. The research was performed between November 2012 and March 2013. Adherence was evaluated using a standardized questionnaire OS- MMAS (Osteoporosis-specific Morisky Medication Adherence Scale). RESULTS: A total of 363 postmenopausal women aged 55 years and older with osteoporosis or osteopenia were participated in the study. 133 (36,6 %) women used weekly dosage forms of BIS (alendronate, alendronate and vitamine D in a fixed combination, risedronate) and 230 (63,4 %) women used...
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Attitudes of patients toward the antidepressant therapy
Dvořáčková, Vendula ; Herink, Josef (advisor) ; Vopršalová, Marie (referee)
Vendula Dvořáčková Attitudes of patients toward antidepressant medication Master's thesis Charles University in Prague, the Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Pharmacy Background: The master's thesis deals with evaluation of attitudes of inpatients in the psychiatric clinic of Military University Hospital Prague. The main task was to clarify the relation between therapy attitude and the prescribed medication, diagnosis and sociodemographic characteristics. Methods: The data were collected using the Drug Attitude Inventory questionnaire (Czech version by Masopust) where sum of negative and positive answers was used to determine the patient's general attitude. Patients' characteristics were acquired from a data-entry form, specific medication from the medical records. Results: In the observed group women seemed to have a more positive attitude toward the treatment compared to men, similarly to people with a higher level of education and patients between 31 - 40 years of age in comparison with other age groups. The most positive responses were observed in patients who were prescribed agomelatine, trazodone and paroxetine. People diagnosed with personal disorders or affective bipolar disorder inclined to positive answers as well, on the other hand most negative...
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Confidence in criminal justice and compliance in the Czech Republic
Homolová, Pavla ; Buriánek, Jiří (advisor) ; Podaná, Zuzana (referee)
The thesis is aimed at normative and instrumental aspects of compliance with the law and cooperation with the criminal justice system in the Czech society, namely trust in the police and criminal courts and their perceived legitimacy, personal morality and perceived risk of sanctions. Its purpose was to empirically verify the revised Tyler's procedural justice model of compliance as suggested by Jackson et al. (2011) within the Czech context. A review of literature on the topic implied potential constraints to validity of the model in the Czech society, mainly in respect to low levels of trust and legitimacy of the police and courts. Nevertheless, the empirical analysis based on structural equation modelling with use of two representative datasets (ESS Round 5 2010, Bezpečnostní rizika 1999) indicates trust in police procedural fairness to be - in contrast to fear of sanctions - a strong factor in predicting compliance. The obligation to obey the law shaped mainly by trust in procedural fairness and personal morality appear to be comparatively the most important predictors of compliance in the Czech Republic. The model was not significant in case of courts nor for the 1999 dataset, probably due to poor internal consistency of some constructs. Keywords confidence, legitimacy, criminal justice, compliance
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Applications of chiral and achiral chromatography in pharmacology and toxicology
Chytil, Lukáš ; Slanař, Ondřej (advisor) ; Bultas, Jan (referee) ; Coufal, Pavel (referee)
Development and validation of methods for analysis of several drugs or their metabolites are decribed in this thesis. The document is presented as a commentary to the original papers, which were published in peer reviewed journals. Discussion on the optimization of each method is presented and covers also method development and influence of preanalytical aspects. Additionally, examples of the application of the developed methods in clinical pharmacology and toxicology are shown. This dissertation consists of three parts: enantiomeric determination of tramadol and its metabolite, determination of some antihypertensive drugs, and qualitative analysis of benzodiazepines. Development of a method for chiral analysis of tramadol and its desmethylated metabolite O- desmethyltramadol (ODT) in human urine and plasma is described in the first part of the thesis. Tramadol is a centrally acting analgetic drug, which is used as racemate in clinical practise. Each enantiomer displays different binding properties for various receptors: (+)-tramadol preferentially inhibits serotonin reuptake while (-)-tramadol mainly inhibits noradrenalin reuptake. (+)-tramadol is considered 10-times more potent than (-)-tramadol. Major active metabolite (ODT), which is considered to be the main agent responsible for the...
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The Effect of Personal Causality Orientation on Adherence in Outpatient Physiotherapy
Kuta, Igor ; Niederlová, Markéta (advisor) ; Hrachovinová, Tamara (referee)
(in English) This master thesis deals with themes of motivations and compliance to treatment recommendations in outpatient physiotherapy. In the theoretical section it brings an introduction to the issue of adherence as a part of medical rehabilitation. It sheds some light on the importance of the research in this field and structures its span according to prescribed diagnoses and other criteria. It also shows distinctions in concepts of compliance, concordance and adherence and summarizes the findings of the most relevant directions of motivation research in this area of study. The aim of the empirical part is to capture relations between the distribution of patients' personal causality orientation and their adherence to treatment. Based on the results of a DOPO method, self-assessment of adherence and evaluation of adherence by the treating physiotherapist, from the sample of 69 patients it concludes, that there is no statistically significant relation between the aforementioned variables.
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Optimization of an aircraft wing rib
Kopřiva, Lubomír ; Suchánek, Miroslav (referee) ; Petruška, Jindřich (advisor)
Topology optimization is a method providing new direction in designing of a technical objects. The aim of topology optimization is to find optimal distribution of material in design space. This diploma thesis is focused on optimization of aircraft wing rib num.6 of the airplane EV-55 using a software HW/Optistruct 7.0 implemented in a software package HyperWorks 7.0. The optimization of the rib was calculated under four different load cases. Resulting shapes of the rib were then tested by strenght calculations in software ANSYS 10.0. Finally, the obtained data of weights of optimized ribs were compared with the weight of the original rib.
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Compliance Analysis in IT Management
Halinár, Martin ; Hromek, Martin (referee) ; Chlebovský, Vít (advisor)
Tato práce se zabývá jednou z významných částí fungování velkých korporací, tedy Compliance, se zvláštní pozorností na IT management. Diplomová práce zevrubně prozkoumává danou oblast. Tento průzkum si klade zároveň za cíl nalezení obtíží, ke kterým dochází v každodenní praxi. Následně je nastíněn způsob možných řešení zjištěných problematických jevů.
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Compliance Algorithms in dynamic service oriented systems
Šabatová, Ivana ; Doucek, Petr (advisor) ; Ivánek, Jiří (referee) ; Kreslíková, Jitka (referee) ; Gregor, Jiří (referee)
Compliance achievement and assurance of processes and services with regulatory requirements, standards, and business requirements becomes an actual task that should be resolved already in the stage of information systems design and implementation. If the particular business process or business service is supported with an IT system, then the compliance assurance relates also to this supporting system. This dissertation thesis presents the concept of continual compliance management in service oriented systems with a special focus on application of advanced process automation tools. The aim of this thesis was design of methods and procedures for reliability and credibility of business processes both internally in single domain, and in case of business process outsourcing including iterated and/or dynamic outsourcing i.e. in multi-domain environment with a special emphasis on automation level maximization. Particular process and/or service is considered to be reliable and credible if we are able to prove its compliance with the defined requirements in a trusted way. The first part of this thesis is dedicated to traditional methods for compliance achievement and assurance as a basis and inspiration for methods based on high level of automation. The second part of this thesis presents the concept of design, implementation and verification of compliance in service oriented systems. It introduces the terms of ideal target process, Key Assurance Indicator (KAI) and Key Security Indicator (KSA). For multi-domain environment there is the concept of Protection Level Agreement (PLA). This part also covers a new method of business process analysis designed for their automation as well as a concept of business rules design, testing and automation integration. The third part named Conceptual Model of Compliance Assurance in BPMS and Service Oriented Systems Environment brings a method inspired by well-known Deming Cycle (Plan, Do, Check, Act), description of the notations selected for compliance algorithm and target process modelling, and first of all the compliance algorithm design. This concept is demonstrated on two case studies of real business processes analyzed in Hospital San Raffaele in Milan, Italy. First of them is an internal business process regulated by regional law, the second study is an example of compliance with business requirement achievement and assurance in multi-domain environment of iterated dynamic outsourcing. These case studies were verified by simulation with subject matter experts and business process activities performers of the hospital personnel.
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