National Repository of Grey Literature 16 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
Follow-up of patiens after COVID-19 monoclonal antibodies administration
Minaříková, Jiřina ; Zimčíková, Eva (advisor) ; Hendrychová, Tereza (referee)
Follow-up of patients after COVID-19 monoclonal antibodies administration Author: Jiřina Minaříková Supervisor: PharmDr. Eva Zimčíková, Ph.D. Consultant: PharmDr. Petra Rozsívalová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Keywords: COVID-19, coronavirus, monoclonal antibodies, casirivimab and imdevimab, REGN-COV2 Introduction: At height of COVID-19 pandemic surge of Delta variant, monoclonal antibodies became a vital treatment option for SARS-CoV-2 positive outpatients at high risk of severe disease progression. Casirivimab and imdevimab (C/I) were used as an unauthorised medicinal product REGN-COV2 under European Medicines Agency emergency use authorisation (EUA). There was paucity of real-world data on safety and effectiveness. Objective: The study aimed to describe REGN-COV2 drug safety, self-reported symptom burden in SARS-CoV-2 positive outpatients within 90 days post C/I infusion. Methods: Prospective multicentric study of SARS-CoV-2 positive outpatients with mild symptoms at high-risk of severe COVID-19 progression (defined criteria under EUA authorization for C/I ambulatory administration) was conducted from September 2021 till April 2022 in three teaching hospitals in Czech Republic and Slovakia. The data collected...
Analysis of patient adherence to treatment by DOAC II
Janáčková, Natália ; Malý, Josef (advisor) ; Hendrychová, Tereza (referee)
6 Abstract Analysis of patient adherence to treatment by DOAC II Author: Natália Janáčková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Simona Dvořáčková, Ph.D., Mgr. Eliška Mašková Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Dosing interval may be an important factor influencing adherence to direct oral anticoagulant (DOAC) therapy. In terms of adherence, a once-daily regimen appears to be a better alternative. However, there may be a higher risk of treatment failure if the dose is missed. The aim of the practical part of the thesis was to analyse patients' attitudes and experiences with DOACs, complemented by data from medical records, with a focus on aspects related to DOAC dosing. Methods: Data collection for this prospective study was carried out from 2020 to 2022 at the Internal Cardiology Outpatient Clinic of the University Hospital in Brno. Patients aged ≥ 18 years on DOAC treatment with indicated atrial fibrillation (FS) were approached to participate in the study. Each patient underwent a structured interview with a trained pharmacist on the day of study entry and again after 3 and 6 months. Two validated and three supplementary questionnaires were used in the interview. Patients' attitudes, experiences...
Analysis of adherence to application technique in COPD patients
Jachanová, Klára ; Hendrychová, Tereza (advisor) ; Ťupová, Lenka (referee)
Analysis of adherence to application technique in COPD patients Author: Klára Jachanová Tutor: PharmDr. Tereza Hendrychová, Ph.D. Consultant: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Adherence is an sssential component of patient care and is also important for achieving treatment goals. Poor adherence leads to increased morbidity, mortality and healthcare expenditures. The aim of this study was to analyze adherence to application technique in patients with chronic obstructive pulmonary disease (COPD), taking into account inhaler device and patient characteristics. Methods: The Czech Multicenter Research Database of COPD, non-interventional observational prospective study, was used as a source of clinical data. Adherence to the application technique was evaluated using Five Steps Assessment. Patients were recruited to the study from August 2013 to December 2016 by 14 outpatient secondary health care centers providing respiratory physician- based care to patients with COPD throughout the Czech Republic. Each of the five consecutive steps was evaluated by a trained healthcare professional. The study evaluated dry powder inhaler and pressurised matered-dose inhaler. Physical and...
Analysis of the provision of consultancy during the dispensing of selected medicinal products by non-medical staff.
Šmigurová, Alica ; Ťupová, Lenka (advisor) ; Hendrychová, Tereza (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clincal Pharmacy Student Alica Šmigurová Supervisor PharmDr. Lenka Ťupová, Ph.D. Title of thesis Analysis of the provision of consultancy during the dispensing of selected medicinal products by non medical staff Introduction: Selected medicinal products are medicinal products that are available outside of pharmacy. They can be often obtained in supermarkets and petrol stations. Objectives: The main goal of this research was to analyse the real situation in the stores selling SMP, according to good practise and the provision of consultancy during the selling of SMP by staff in Hradec Králové and its near surrounding. The purpose was extended to finding the availability and selling of SMP in Czech Republic. Methods: The practical part consisted of two phases. In the first phase, two anonymous visits were done. The first visit went on without asking staff. During the second visit the staff was asked for advice. The second phase consisted of an online questionnaire about demand, availability and saleability of SMP. In total, 2632 retailers were asked about took part in it. Results: In the most cases from 28 ones (89 %) SMP were stored free in selling area, in 3 stores (11%) VLP were in a locked cabinet. All stores had...
Follow-up of patiens after COVID-19 monoclonal antibodies administration
Minaříková, Jiřina ; Zimčíková, Eva (advisor) ; Hendrychová, Tereza (referee)
Follow-up of patients after COVID-19 monoclonal antibodies administration Author: Jiřina Minaříková Supervisor: PharmDr. Eva Zimčíková, Ph.D. Consultant: PharmDr. Petra Rozsívalová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Keywords: COVID-19, coronavirus, monoclonal antibodies, casirivimab and imdevimab, REGN-COV2 Introduction: At height of COVID-19 pandemic surge of Delta variant, monoclonal antibodies became a vital treatment option for SARS-CoV-2 positive outpatients at high risk of severe disease progression. Casirivimab and imdevimab (C/I) were used as an unauthorised medicinal product REGN-COV2 under European Medicines Agency emergency use authorisation (EUA). There was paucity of real-world data on safety and effectiveness. Objective: The study aimed to describe REGN-COV2 drug safety, self-reported symptom burden in SARS-CoV-2 positive outpatients within 90 days post C/I infusion. Methods: Prospective multicentric study of SARS-CoV-2 positive outpatients with mild symptoms at high-risk of severe COVID-19 progression (defined criteria under EUA authorization for C/I ambulatory administration) was conducted from September 2021 till April 2022 in three teaching hospitals in Czech Republic and Slovakia. The data collected...
Analysis of economical development of health insurance companies in the Czech Republic
Žalmánek, Ondřej ; Hendrychová, Tereza (advisor) ; Babica, Jan (referee)
Analysis of economical development of health insurance companies in the Czech Republic Author: Ondřej Žalmánek Supervisor: PharmDr. Tereza Hendrychová, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Introduction and Objective: Health insurance companies play an important role in health care system in the Czech Republic. Their main task is to ensure the payment of health services in the form of health insurance. The objective of the work was to analyze the development of health insurance companies in the Czech Republic with a focus on the costs of medicinal products (MP) and medical devices (MD) dispensed on medical prescription in the years 2018-2020. Methodology: Data on health insurance companies' economy were obtained from the annual reports for the years 2018-2020, which health insurance companies publish on their websites. Data on the total costs of selected health services related to prescription of MP and MD and expenses for MP and MD dispensed on prescription issued by health service providers were processed. For the possibility of comparison, the data were converted to one insured person. The data were processed using Microsoft Excel software and evaluated by methods of descriptive and comparative statistics. Results: Health...
Analysis of enquiries from drug information centre focused on pharmacotherapy of pregnant and nursig women
Rožníčková, Eliška ; Malá, Kateřina (advisor) ; Hendrychová, Tereza (referee)
Analysis of enquiries from Drug Information Centre focused on pharmacotherapy of pregnant and breastfeeding women Author: Mgr. Eliška Rožníčková Consultant: PharmDr. Kateřina Malá, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: The Drug Information Centre (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and the University Hospital Hradec Králové (FAF UK and FN HK), established in 1994, has been providing, among other services, safety evaluations of pharmacotherapy used during pregnancy and breastfeeding via answers to drug enquiries from healthcare professionals. Aim: This study aimed to analyse drug enquiries from the DIC FAF UK and FN HK focused on pharmacotherapy of pregnant and breastfeeding women from 2012 to 2021. Methods: In the observed period, the retrospective analysis of enquiries registered in the DIC database was focused on the enquirers' profession, the region of the workplace, the urgency and the character of enquiries, the anatomical-therapeutical- chemical classification of drugs included in enquiries, used information resources, time required for solving enquiries and feedback of enquirers. Reasons of contacting the DIC, factors affecting the risk of drugs (e.g....
Vaccination and pharmaceutical care I
Žižková, Tereza ; Malý, Josef (advisor) ; Hendrychová, Tereza (referee)
Vaccination and pharmaceutical care I Author: Tereza Žižková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Eliška Kolmanová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim of study: Vaccination can be considered an effective tool for the prevention of infectious diseases. Its main importance lies in the protection of the entire population. The aim of this thesis was to analyze the attitudes and opinions of patients regarding the possibility of vaccination against influenza in pharmacies in the Czech Republic (CZ). Methods: The research consists of the answers of 2032 citizens of the CZ over the age of 15, randomly selected by the technique of the standardized quided interview. They were approached between 16. 11. 2020 and 20. 12. 2020 with a request for comments on the issue of healthcare and the healthy lifestyle of the population. Part of this survey were questions about the issue of vaccination against influenza. Respondents were asked 21 closed, semi-closed and open-ended questions focused on socio-demographic characteristics, attitudes and opinions of respondents on influenza vaccination, including the possibility of vaccination in a pharmacy. Data were evaluated with descriptive statistics and...
Effect of MDOC Nanotextilie on Healing an Acute Dermal Wound.
Hendrychová, Tereza ; Semecký, Vladimír (advisor) ; Šimkovič, Dušan (referee)
Tereza Hendrychová The influence of MDOC nanotextile on the healing of an acute dermal wound Diploma paper Charles University in Prague, The Faculty Of Pharmacy in Hradec Králové Pharmacy In this work there are summarized general information about the course of the healing process of acute dermal wounds and their nursing. There are described the inflammatory mediators (cytokines) in more details. In experiment there was assessed the influence of M-DOC® (microdispersed oxidized cellulose) with gentamycin joined on it on the process of the healing of acute dermal wounds. The formulation was called Nanogenta. Domestic pig, Sus scrofa was used as an experimental model. There were 12 animals used, in the experiment. For the demonstration of effectivity of tested formulation the wounds were infected (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli). The effectivity of tested formulation was confronted with preparations, that have demonstrated their effect in clinical use yet (Garamycin Schwann® , Hyiodine® ). There were performed macroscopic, microbiology and microscopic evaluation. There were demonstrated sufficient effect of Nanogenta on improving the quality of the healing process of dermal wounds, which was comparable with an effect of the preparations, which were used as a control....
Patients' attitudes to pharmacotherapy of osteoporosis
Theimerová, Hana ; Vytřísalová, Magda (advisor) ; Hendrychová, Tereza (referee)
1 ABSTRACT PATIENTS' ATTITUDES TO PHARMACOTHERAPY OF OSTEOPOROSIS Author: Hana Theimerová Supervisor: Magda Vytřísalová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy INTRODUCTION: Patients' attitudes to treatment might be affected by various factors. These may vary in different generations as well as in different populations. The patients' attitudes to the treatment along with the illness may affect decision concerning the beginning, interruption or end of the treatment. That implies that the interaction between these factors and attitudes to the treatment is comprehensive. AIMS: The study aim was to evaluate the patients' attitudes to the treatment of osteoporosis based on the perception of necessity and concerns of treatment with oral bisphosphonates (BIS). METHODS: Data for the analysis were obtained using an anonymous questionnaire in five outpatient centres in the Czech Republic from November 2012 to March 2013. The patients' opinions concerning the BIS treatment were identified (necessity vs. concerns) using the Czech version of the "Beliefs about Medicines Questionnaire Specific" (BMQ-CZ). RESULTS: A total of 363 patients were involved in the analysis (mean age 68.9 years). Patients were treated with once a week dosing forms of BIS -...

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