National Repository of Grey Literature 94 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers
Preiss, Přemysl ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers Author: Přemysl Preiss Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Endoprosthetic surgeries are demanding orthopedic surgeries rarely associated with complications, that can be fatal. One is periprosthetic joint infection (PJI), whose risk can be decreased by antibiotic prophylaxis (AP). The aim of this effort was to describe trends in endoprosthetic surgeries of the knee and the hip, their complications and options of diagnostics in the theoretical part. The aim of the practical part was to analyze prognostic features of chosen laboratory parameters on postoperative infections, respectively on postoperative complications. Methods: This prospective study started in March 2020 and data gathering took place until 28. 3. 2022 at the Ortopedic Clinic of the University Hospital Hradec Králové. Patients, who were included in the study, fulfilled the preliminary criteria, e.g. age ≥ 18 years, patient undergoing total hip or knee arthroplasty at the time of the study and giving the informed consent to the study. Data were gathered from...
Analysis of drug administration by nurses in health facility XIV
Newaldová, Sandra ; Doseděl, Martin (advisor) ; Rejmanová, Anna (referee)
Analysis of drug administration by nurses in health facility XIV. Author: Sandra Newaldová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Medication errors are one of the causes of adverse events in healthcare facilities, leading to patient endangerment or harm. A study looking at this issue reports that the most common errors occur when a nurse administers medicines in a healthcare facility. Aim: The aim of the thesis is to monitor medication errors of nurses during the preparation and administration of medication to patients and to analyse the prevalence of medication errors, determine their type, their relationship to other influencing factors, and their severity with respect to the patient's condition. Methods: Prospective observational study with direct observation method, conducted in a specialized medical rehabilitation facility. The study included two pre- and post- intervention phases in which nurses' medication and procedural errors were monitored, analysed and evaluated. Observations were conducted in each phase over three days each time during morning, midday and evening administration. The results were analysed in programs Microsoft Excel and Wolfram Mathematica. Results: The...
Diagnostic module for Single-Wire CAN bus
Jež, Michal ; Doseděl, Martin (referee) ; Havránek, Zdeněk (advisor)
The basic properties of the CAN bus are analyzed in the bachelor's thesis. Furthermore, this work deals with the availability of circuits for the implementation of the CAN bus and the physical layer Single Wire CAN. Subsequently, the design of the diagnostic unit for the CAN bus is processed. It also deals with the design of firmware for the diagnostic module and a PC program for subsequent data analysis. Finally, the compatibility of the Single Wire CAN bus with the Low Speed CAN bus is tested.
Measurement system with preamplifier for calibration of vibration sensors
Kaštovský, Jan ; Doseděl, Martin (referee) ; Havránek, Zdeněk (advisor)
This thesis deals with the design and implementation of a preamplifier for vibration sensors with IEPE interface and also for vibration sensors with charge output. The thesis also deals with a modification of a computer application for a measuring system in LabVIEW. The thesis builds on the already implemented measuring system for secondary calibration of vibration sensors. The results of the secondary calibration of this system with the added preamplifier are compared with the results of a primary calibration.
Analysis of drug administration by nurses in health facility XI
Altmannová, Tereza ; Doseděl, Martin (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XI Author: Tereza Altmannová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are intrinsically linked to the practice of the medical profession. They can occur at several levels - prescription, drug preparation, dispensation, administration, and subsequent use of the drug by the patient. Nurses play an important role in the process of the drug administration in a hospital setting. Because of the occurrenceof medication errors and the consequent inability to achieve desired health outcomes, efforts are nowadays made to detect and minimize them. The aim of this study was to detect and analyze medication errors occurring during drug administration by nurses in a healthcare facility in South Bohemia. Methodology: The study is a part of a multi-year project involving the Faculty of Pharmacy of Charles University. The methodology is based on an observational study. The data collection took place in April 2022. Three hospital wards were assigned for the observation, where morning, midday and evening drug administration was monitored for three consecutive days. Data were recorded on a pre- generated form based on the...
Analysis of drug dosage adjustments in patients with chronic kidney disease
Procházková, Jana ; Vlček, Jiří (advisor) ; Doseděl, Martin (referee)
Candidate: Jana Procházková1 Supervisor: prof. RNDr. Jiří Vlček, CSc.1 Consultant: PharmDr. Zuzana Očovská1 Title of the master thesis: Analysis of drug dosage adjustments in patients with chronic kidney disease 1 Department Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Several medications excreted by the kidneys or associated with an increased risk for adverse drug events in patient with chronic kidney disease (CKD) require dosage adjustment, cautious use or avoidance. However, a number of studies show that appropriate dosage adjustment is not provided in many cases. Our objective was to analyze appropriateness of drug dosages and contraindicated medications in patients with CKD admitted to the hospital in Hradec Králové via the department of emergency medicine. This study is an observational cross-sectional study and represents a sub-study of the previous study that examined drug-relatedness of unplanned hospital admissions to University Hospital Hradec Králové in 2018. The data were obtained from electronic medical records. The appropriateness of drug use and drug dosages was analyzed in patients with an estimated glomerular filtration rate (eGFR) between 15 and 60 mL/min/1.73 m2 based on comparison with the Summary of Product Characteristics (SmPC). The...
Analysis of drug-related problems in a healthcare facility VIII
Kraušnerová, Kateřina ; Doseděl, Martin (advisor) ; Horký, Pavel (referee)
Analysis of drug-related problems in healthcare facility VIII Author: Kateřina Kraušnerová Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Backgroung: Drug-related problem (DRP) is according to Pharmaceutical Care Network Europe (PCNE) pharmacotherapy related event or circumstance, which actually or potentionaly interfer with a terapeutic purpose. Pharmacists tend to be part of multidisciplinar teams, they help with decisions concerning therapy of the patient, monitoring, participating in the detection of DRPs and by that helping increase effect and safety of pharmacotherapy. Aim: The aim of the theoretical part of this thesis is to cteate summary of DRPs which occurs in antidepressant drug group, ATC N06A, and classify these problems using PCNE V5.01 classification. The aim of the practical part of this thesis is to detect DRPs in healthcare facility, classify these DRPs using PCNE V5.01 classification and asses their relevance and acceptance of interventions made by clinical pharmacist. Methodology: The data were collected since February 7th to March 7th 2022 at hospital in the Czech republic. In total it was collected data from 68 patients. Source of DRPs, their relevance and suggested...
Evaluation of clinical pharmacists interventions in the hospital II
Elbelová, Šárka ; Doseděl, Martin (advisor) ; Babica, Jan (referee)
Evaluation of clinical pharmacists interventions in the hospital III Author: Šárka Elbelová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Considering the constant development of health care it is highly relevant to analyze the contribution of the clinical pharmacist and the potential for further improvement of the drug management. In the theoretical part, special focus is on the phenomenon of physicians' acceptance of recommendations made by clinical pharmacist. It also summarizes the recent studies on this topic. In the following analysis in practical part, the interventions of clinical pharmacist are put under scrutiny as well as the types of the drug-related problems, which are encountered by the clinical pharmacist, the seriousness of these problems and their possible solutions. Furthermore, the physicians' acceptance of recommendations made by clinical pharmacist is measured. Methods: A prospective, descriptive study was conducted in the Nursing Unit of the Department of the Internal Medicine in the Hospital in Olomouc region between October and December 2021. Only newly admitted patients whose pharmacotherapy was revised were considered. The data (age, sex, diagnosis,...
Biologic drug (biologics) Consumption in Czech Republic II
Farkašová, Veronika ; Horký, Pavel (advisor) ; Doseděl, Martin (referee)
Consumption of biologic drugs (biologics) in the Czech Republic Author: Veronika Farkašová Supervisor: doc. PharmDr. Jozef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Biological treatment is modern alternative to chemotherapeutics especially in patients with difficult-to-treat diseases of autoimmune origin, as well as patients with other diseases as is cancer. They are heavily used in oncology for their wide range of indications. They are used as a monotherapy as well as in combination with traditional chemotherapy. Use of biological treatment can reduce the amount of treatment cycles of chemotherapy and reduce unwanted adverse effects. Objective: The aim of the diploma theasis was to analyze the consumption of biologigal treatment rituximab, bevacizumab, cetuximab and alemtuzumab. Methods: A retrospective analysis of the consumption of biosimilars rituximab, bevacizumab, cetuximab and alemtuzumab was performed from 1. 1. 2010 to 31. 12. 2020. The selection of specific biosimilars was made on the basis of their wide indication spectrum. Consumption data were obtained from the database of the State Institute for Drug Control (SÚKL). Descriptive statistics were used for the analysis. Consumption, given in the number...
Analysis of drug administration by nurses in health facility XIV
Newaldová, Sandra ; Doseděl, Martin (advisor) ; Rejmanová, Anna (referee)
Analysis of drug administration by nurses in health facility XIV. Author: Sandra Newaldová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Medication errors are one of the causes of adverse events in healthcare facilities, leading to patient endangerment or harm. A study looking at this issue reports that the most common errors occur when a nurse administers medicines in a healthcare facility. Aim: The aim of the thesis is to monitor medication errors of nurses during the preparation and administration of medication to patients and to analyse the prevalence of medication errors, determine their type, their relationship to other influencing factors, and their severity with respect to the patient's condition. Methods: Prospective observational study with direct observation method, conducted in a specialized medical rehabilitation facility. The study included two pre- and post- intervention phases in which nurses' medication and procedural errors were monitored, analysed and evaluated. Observations were conducted in each phase over three days each time during morning, midday and evening administration. The results were analysed in programs Microsoft Excel and Wolfram Mathematica. Results: The...

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3 Doseděl, Marek
4 Doseděl, Miroslav
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