National Repository of Grey Literature 89 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Analysis of drug dosage adjustments in patients with chronic kidney disease
Procházková, Jana ; Vlček, Jiří (advisor) ; Doseděl, Martin (referee)
Candidate: Jana Procházková1 Supervisor: prof. RNDr. Jiří Vlček, CSc.1 Consultant: PharmDr. Zuzana Očovská1 Title of the master thesis: Analysis of drug dosage adjustments in patients with chronic kidney disease 1 Department Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Several medications excreted by the kidneys or associated with an increased risk for adverse drug events in patient with chronic kidney disease (CKD) require dosage adjustment, cautious use or avoidance. However, a number of studies show that appropriate dosage adjustment is not provided in many cases. Our objective was to analyze appropriateness of drug dosages and contraindicated medications in patients with CKD admitted to the hospital in Hradec Králové via the department of emergency medicine. This study is an observational cross-sectional study and represents a sub-study of the previous study that examined drug-relatedness of unplanned hospital admissions to University Hospital Hradec Králové in 2018. The data were obtained from electronic medical records. The appropriateness of drug use and drug dosages was analyzed in patients with an estimated glomerular filtration rate (eGFR) between 15 and 60 mL/min/1.73 m2 based on comparison with the Summary of Product Characteristics (SmPC). The...
Analysis of drug-related problems in a healthcare facility VIII
Kraušnerová, Kateřina ; Doseděl, Martin (advisor) ; Horký, Pavel (referee)
Analysis of drug-related problems in healthcare facility VIII Author: Kateřina Kraušnerová Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Backgroung: Drug-related problem (DRP) is according to Pharmaceutical Care Network Europe (PCNE) pharmacotherapy related event or circumstance, which actually or potentionaly interfer with a terapeutic purpose. Pharmacists tend to be part of multidisciplinar teams, they help with decisions concerning therapy of the patient, monitoring, participating in the detection of DRPs and by that helping increase effect and safety of pharmacotherapy. Aim: The aim of the theoretical part of this thesis is to cteate summary of DRPs which occurs in antidepressant drug group, ATC N06A, and classify these problems using PCNE V5.01 classification. The aim of the practical part of this thesis is to detect DRPs in healthcare facility, classify these DRPs using PCNE V5.01 classification and asses their relevance and acceptance of interventions made by clinical pharmacist. Methodology: The data were collected since February 7th to March 7th 2022 at hospital in the Czech republic. In total it was collected data from 68 patients. Source of DRPs, their relevance and suggested...
Evaluation of clinical pharmacists interventions in the hospital II
Elbelová, Šárka ; Doseděl, Martin (advisor) ; Babica, Jan (referee)
Evaluation of clinical pharmacists interventions in the hospital III Author: Šárka Elbelová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Considering the constant development of health care it is highly relevant to analyze the contribution of the clinical pharmacist and the potential for further improvement of the drug management. In the theoretical part, special focus is on the phenomenon of physicians' acceptance of recommendations made by clinical pharmacist. It also summarizes the recent studies on this topic. In the following analysis in practical part, the interventions of clinical pharmacist are put under scrutiny as well as the types of the drug-related problems, which are encountered by the clinical pharmacist, the seriousness of these problems and their possible solutions. Furthermore, the physicians' acceptance of recommendations made by clinical pharmacist is measured. Methods: A prospective, descriptive study was conducted in the Nursing Unit of the Department of the Internal Medicine in the Hospital in Olomouc region between October and December 2021. Only newly admitted patients whose pharmacotherapy was revised were considered. The data (age, sex, diagnosis,...
Biologic drug (biologics) Consumption in Czech Republic II
Farkašová, Veronika ; Horký, Pavel (advisor) ; Doseděl, Martin (referee)
Consumption of biologic drugs (biologics) in the Czech Republic Author: Veronika Farkašová Supervisor: doc. PharmDr. Jozef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Biological treatment is modern alternative to chemotherapeutics especially in patients with difficult-to-treat diseases of autoimmune origin, as well as patients with other diseases as is cancer. They are heavily used in oncology for their wide range of indications. They are used as a monotherapy as well as in combination with traditional chemotherapy. Use of biological treatment can reduce the amount of treatment cycles of chemotherapy and reduce unwanted adverse effects. Objective: The aim of the diploma theasis was to analyze the consumption of biologigal treatment rituximab, bevacizumab, cetuximab and alemtuzumab. Methods: A retrospective analysis of the consumption of biosimilars rituximab, bevacizumab, cetuximab and alemtuzumab was performed from 1. 1. 2010 to 31. 12. 2020. The selection of specific biosimilars was made on the basis of their wide indication spectrum. Consumption data were obtained from the database of the State Institute for Drug Control (SÚKL). Descriptive statistics were used for the analysis. Consumption, given in the number...
Analysis of drug administration by nurses in health facility XIV
Newaldová, Sandra ; Doseděl, Martin (advisor) ; Rejmanová, Anna (referee)
Analysis of drug administration by nurses in health facility XIV. Author: Sandra Newaldová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Medication errors are one of the causes of adverse events in healthcare facilities, leading to patient endangerment or harm. A study looking at this issue reports that the most common errors occur when a nurse administers medicines in a healthcare facility. Aim: The aim of the thesis is to monitor medication errors of nurses during the preparation and administration of medication to patients and to analyse the prevalence of medication errors, determine their type, their relationship to other influencing factors, and their severity with respect to the patient's condition. Methods: Prospective observational study with direct observation method, conducted in a specialized medical rehabilitation facility. The study included two pre- and post- intervention phases in which nurses' medication and procedural errors were monitored, analysed and evaluated. Observations were conducted in each phase over three days each time during morning, midday and evening administration. The results were analysed in programs Microsoft Excel and Wolfram Mathematica. Results: The...
Analysis of drug administration by nurses in health facility IX
Blažková, Kateřina ; Doseděl, Martin (advisor) ; Košťálová, Barbora (referee)
Analysis of drug administration by nurses in a health facility X Author: Kateřina Blažková Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy, in Hradec Králové, Charles University Introduction and aims: Currently, patients are treated primarily through pharmacotherapy. As a consequence of this fact, an ever-increasing incidence of medication errors can be expected. Medication errors and the resulting adverse events can have adverse consequences for the patient and, consequently, for the entire healthcare system. The aim of this study was to analyse the whole process of drug administration by nurses in inpatient wards in a South Bohemian hospital. Methods: This thesis is part of an ongoing research project involving the Faculty of Pharmacy of Charles University. The first data collection took place in 2021, followed by interventions towards nurses, doctors and hospital management. The data collection for this work was similarly conducted using the direct observation method for three consecutive days from 2 to 5 May 2022. Using a trained multidisciplinary team consisting of a pharmacist and a nurse, the internal medicine, surgery and aftercare departments were observed. Morning, midday and evening medication administration was observed in each ward....
Analysis of drug administration by nurses in health facility XI
Altmannová, Tereza ; Doseděl, Martin (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XI Author: Tereza Altmannová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are intrinsically linked to the practice of the medical profession. They can occur at several levels - prescription, drug preparation, dispensation, administration, and subsequent use of the drug by the patient. Nurses play an important role in the process of the drug administration in a hospital setting. Because of the occurrenceof medication errors and the consequent inability to achieve desired health outcomes, efforts are nowadays made to detect and minimize them. The aim of this study was to detect and analyze medication errors occurring during drug administration by nurses in a healthcare facility in South Bohemia. Methodology: The study is a part of a multi-year project involving the Faculty of Pharmacy of Charles University. The methodology is based on an observational study. The data collection took place in April 2022. Three hospital wards were assigned for the observation, where morning, midday and evening drug administration was monitored for three consecutive days. Data were recorded on a pre- generated form based on the...
Analysis of drug administration by nurses in health facility XII
Gröszlová, Anna ; Doseděl, Martin (advisor) ; Malý, Josef (referee)
ANALYSIS OF DRUG ADMINISTRATION BY NURSES IN HEALTH FACILITY XII Author: Anna Gröszlová Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Introduction: Medication administration in healthcare facilities significantly affects patient's safety. Observing and analyzing this process provide information about medication administration errors and the factors influencing them. As a result of observational findings, we can create interventions to improve the administration process. Aim: The aim of this work was to describe and analyze medication administration errors in a healthcare facility. Methods: The direct observation method was used for observation. Data collection took place in three departments (surgery, neurology, follow-up care) in 2021 and 2022. In both years, collection took place in each department on 3 consecutive days. Morning, midday and evening medication administration was monitored. An electronic database was used for recording. Data evaluation was done in Microsoft Excel and data from 2021 and 2022 were analyzed together. Nurse's work practices and medication errors were evaluated. Results: In total, 1160 drug administrations to 114 patients were observed. The largest number of...
Verification properties of AV test bench
Kraiushkin, Dmytro ; Doseděl, Martin (referee) ; Klusáček, Stanislav (advisor)
This bachelor's thesis deals with the vibration diagnostics of rotating machinery and familiarization with the hardware and software provided by AMC Vibro company. A research was conducted on the issues of diagnosing faults in rotating machinery and their potential application on the rotor model AV Test Bench. The main focus of the thesis is the diagnosis of shaft unbalance and the implementation of the operational two-plane balancing method.
Analysis of drug utilization of antidiabetics
Dvořáková, Nelly ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of drug utilization of antidiabetics Author: Nelly Dvořáková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Simona Dvořáčková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objective: Effects of antidiabetics prevent serious consequences on mortality, morbidity and quality of life of patients. The objective of practical part of this thesis was to analyze trends of antidiabetics utilization in the Czech Republic between 2005−2021. Methods: The utilization of antidiabetics was analysed in the period from 1st January 2005 to 31st December 2021. The data were obtained from the State Institute for Drug Control database, where are collected reports from distributors regarding the supplies to healthcare institutions including pharmacies, vendors of selected pharmaceuticals and veterinarians. The denominator was number of inhabitants in Czech Republic in particular years in study period. The drug utilization of antidiabetics in Defined Daily Doses (DDD) was converted to Defined Daily Dose/1000 inhabitants/day (DID). The values of DDD of medicaments in fixed combinations were also converted to DID but not converted to their single components. The descriptive statistics was used to analyze the data. Results:...

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3 Doseděl, Marek
2 Doseděl, Miroslav
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