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Molecular mechanisms of fibroblastoid cell phenotype transitions:dedifferentiation of myofibroblasts and influencing of invasiveness and metastasis of sarcoma
Kosla, Jan ; Dvořák, Michal (advisor) ; Peková, Soňa (referee) ; Reiniš, Milan (referee)
Fibroblasts are the principal cellular component of the connective tissue. They are a heterogeneous group of cells which contribute to the structure of connective tissue and wound healing by their ability to produce extracellular matrix (ECM). Fibroblasts and cells derived from them are involved in many pathological processes such as formation of malignant tumors and fibrosis. Tumor progression which finally leads to metastasis is a serious biomedical problem. There is a growing body of the recent evidence showing an important role of the tumor stroma and its interaction with cancer cells in cancer progression. Tumor stroma comprises mainly of myofibroblasts and their products, namely ECM, soluble factors, and enzymes. Myofibroblasts contribute more or less to all steps of cancer progression. Furthermore myofibroblasts play a key role in fibrosis, another serious human disease which is not efficiently treatable and which is associated with cancer progression. These facts made us to search for molecular means capable of eliminating the myofibroblastic phenotype. We succeeded to entirely dedifferentiate primary myofibroblasts by concomitant inhibition of TGFβ signaling and perturbation of MAPK signaling in a chick model that we have introduced. Malignant fibroblasts form sarcomas. ECM is the first...
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Modelling of lithium ion batteries using ECM
Langer, Lukáš ; Kazda, Tomáš (referee) ; Vyroubal, Petr (advisor)
The main aim of this paper are models of Li-Ion storage batteries made and simulated in ANSYS Fluent software. Various ways of simulations are discussed with main aim on ECM method and how its numerical model is computed. A process of getting information and required data from real battery to be compared with simulation results by EIS method is also discussed. These results are then compared with results from ANSYS Fluent.
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Analyzing and designing a document management system deployment in a selected organization
HOMAN, Jiří
The dissertation deals with an enterprise content management system (ECM). It is divided into two larger parts, theoretical and practical. In the theoretical part, the author describes a lifecycle of enterprise applications and an enterprise content management system. The practical part focuses on analysing the current state and proposing a call for the tender for the supply of the information system.
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Current possible arrangements for a company's document management and circulation
Kučerová Zrálíková, Václava ; Pokorný, Jan (advisor) ; Lipková, Helena (referee)
The thesis analyzes the area of enterprise content management (ECM), identifies its relation to other business applications and defines various stages of the life cycle of documents. It also describes individual components of ECM, including the technologies covering these components. A tool for managing and storing documents (DMS) in ABC company is presented in more detail in the practical part. The Exact Synergy Enterprise software demonstrates its advantages and disadvantages affecting document management and operational problems that this kind of software may carry.
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Interconnections within Food, Biofuel and Fossil Fuel Markets: Cointegration Analysis
Chrz, Štěpán ; Hrubý, Zdeněk (advisor) ; Hildebrandt, Barbora (referee)
This work examines a topic of interconnections within food, biofuel and fossil fuel markets. The first part provides a general description of biofuel types, related policy measures and a development of relevant legal framework in selected regions. Second part describes an analysis of long and short-term causal relationships between commodities. Furthermore, an impact of Energy Policy Act of 2005 on these relationships is examined. The analysis incorporates Johansen cointegration, error correction model, vector autoregression and Granger causality. A number of equilibrium relationships are found across the examined markets suggesting an interconnection of the studied markets. The results of the impact of EPA are inconclusive due to limitations of employed models.
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Monitoring of influence of individual segments of a teaching unit on physical education on fitness of girls from seventh of elememntary school
Floriánová, Linda ; Hráský, Pavel (advisor) ; Bunc, Václav (referee)
Title: Monitoring of influence of individual segments of a teaching unit of physical education on fitness of girls from seventh grade of elementary school. Aim: The aim of the empirical part is to monitor the proportional representation of the motoric activities during the time given in the lessons of physical education of the seventh grade girls, and along with the chosen methods of testing of these individuals, to prove or disprove possible influence of the composition of the P.E. lessons on the chosen segments of their fitness. Methods: Various methods were used for testing the considered sample. These were the standardized motoric tests (intense forward bend when sitting, place-jump with legs together, endurance in a pull-up, hand grip) which investigate the chosen segments of the fitness. Another method used was the bioimpedance which measures the parameters of body composition. The data were recollected quantitatively and the results were also processed quantitatively by means of statistic parameters, such as arithmetic mean, variation span and determinative deviation. Results: From the results of the work emerged that as far as the chosen motoric activities and their influence on the chosen segments of the fitness are concerned, during the time given only the segment of flexibility in...
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System design department for acquisition process at M&A department and its implementation in MS Sharepoint 2013
Pekárková, Alena ; Přibil, Jiří (advisor) ; Bína, Vladislav (referee)
This thesis analyse the implementation of the MS SharePoint solution to the acquisition process of the selected M&A department of multinational enterprise. Analysis of the possible options to use the MS SharePoint 2013 platform for solution of the specific acquisition processes, descriptions of the recommendations for setting-up of the processes via MS SharePoint 2013 and implementation of the MS SharePoint 2013 solution in specific M&A department are the main goals of this thesis. The abovementioned goals are achieved through research in the relevant literature, research papers, based on the lectures provided by company Gopas and consultation with experts from Microsoft company as well as the practical experience of the author of this thesis. The main benefit of this thesis is the comprehensive review of the relevant areas, topics and issues and creation of the suitable solution and recommendations for the specific M&A department.
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Analysis of the ECM market solutions and trends in this area
Ivanko, Lukáš ; Pour, Jan (advisor) ; Derfler, Václav (referee)
This master thesis deals with the analysis of the ECM market solutions and trends in this area. The theoretical part of the thesis focuses on defining theoretical assumptions of studied subject. This part is concluded by the assessment of trends in the ECM field. The practical part of the thesis focuses not only on the analysis of the ECM market but also on detailed analysis of selected suppliers and their ECM solutions, which are analyzed according to selected criteria. Last part of the thesis provides the summary of the performed analysis and evaluation of selected providers.
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Project Planning and Application of Project Management Methodology in Enterprise
Šmaha, Pavel ; Machala, Ondřej (referee) ; Smolíková, Lenka (advisor)
Diploma thesis deals with project management methodology and its application into enterprise environment. The theoretical part describes exact methods of project management and it’s standards and structure. The analytical part describes the situation in company A.S., its corporate structure and the methodology used by management. The practical part follows the previous chapters, describes project management according to the chosen methodology and the results are interpreted both in terms of project success and as compared to the existing methodology.
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Information System Assessment and Proposal for ICT Modification
Mikyska, Vladimír ; Ochotný, Vladimír (referee) ; Koch, Miloš (advisor)
This master’s thesis is focused on information system assessment and proposal for its changes in real company enviroment. Theoretical part describes issue and notions from information systems, analytical instruments, processes and projects enviroment. In analytical part is situated introduction of the company and analysis of current state its information system and processes. Based on findings from analysis are made recomendations and proposals for possible changes.
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