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Hypothermia from the point of view of a paramedic
ŠTĚCHOVÁ, Karolina
Theme of bachelor thesis is a hypothermia from a look of the Emergency Medical Service, (paramedic). The theoretical part of this thesis focuses on the main causes of hypothermia, physiological and anatomic knowledge about a skin, diagnostic hypothermia, procedure in the pre-hospital emergency care, cardiopulmonary resuscitation in a patient with hypothermia and the subsequent intensive care. In the practical part of the thesis, we set one goal and three research questions too.This bachelor thesis maps the awareness of paramedics about the issue of hypothermia. The first research question is aimed at ensuring that the members of Emergency Medical Service (or paramedics) have a sufficient theoretical knowledge of hypothermia.The second research question is focused on the general knowledge of the Emergency Medical Service on specific cardiopulmonary resuscitation in a patient with hypothermia.The third research question examines the paramedics´ expertise in the subsequent intensive care of a patient with hypothermia. The practical part of the thesis consists of a semi-structured interview with twelve paramedics from the South Bohemian Region.The interview included 23 questions. For better orientation, were results seperated to 12 categories.The goal of the bachelor thesis was accomplished thanks to answering all questions related to the research. Paramedics Responders have some knowledge about the topic of hypothermia but it is important to provide more information about the specifics of pharmacotherapy during cardiopulmonary resuscitation on a patient with hypothermia.I rate the research questions about intensive care very positively. This bachelor thesis could be used as a basis for educating students of non-medical pharmaceutical specializations in the future.
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Placental transport of dopamine and norepinephrine
Turková, Helena ; Štaud, František (advisor) ; Jirkovský, Eduard (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Helena Turková Supervisor: prof. PharmDr. František Štaud, Ph.D. Title of diploma thesis: Placental transport of dopamine and norepinephrine During the whole course of pregnancy, it is important to maintain proper monoamine homeostasis, namely serotonin (5-HT), norepinephrine (NE), and dopamine (DA), which are crucial for proper placental function and fetal development. Monoamines are important neuromodulators, involved in cell proliferation, and differentiation. and neuronal migration. High fetal monoamine secretion during gestation demands a responsible clearance mechanism, as disruption of their balance may lead to long-lasting changes in brain structure and function, provoking a higher risk of attention deficit hyperactivity disorder (ADHD), autism or depression. However, uptake of NE a DA through the fetoplacental unit has not been fully and in detail described. Therefore, in this diploma thesis, we focus on the uptake of NE and DA through ex vivo isolated vesicles of microvillous (MVM) and basal (BM) membranes from healthy human term placentas. Our results show that NE and DA uptake is mediated via high-affinity and low-capacity serotonin (SERT) and norepinephrine (NET) transporters in...
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Analysis of the effect of pharmacotherapy on the risk of fall in inpatients II
Szikorová, Nikola ; Malý, Josef (advisor) ; Rejmanová, Anna (referee)
Analysis of the effect of pharmacotherapy on the risk of fall in inpatients II Author: Nikola Szikorová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objectives: Falls are one of the most common problems of hospitalized patients. Their occurrence is associated with many problems and therefore should be avoided. Effective prevention involves analyzing risk factors and implementing interventions to minimize these risks. The aim of this work was to analyze the influence of drugs and other risk factors on the fall of hospitalized patients. Methods: Data was collected from April to December 2017 in 4 hospitals in South Bohemia. Only patients who had fallen during hospitalization participated in the study. An online database was created for the study to collect patient data (personal history, medications used, laboratory values and others). Population and individual fall risk-increasing drugs were analyzed. For each individual fall risk-increasing drug, the type of drug problem that could have been the cause of a fall was classified. Risk minimization interventions have been assigned to each drug problem. In addition to fall risk-increasing drug analysis, other risk factors that increased the risk...
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Analysis of the effect of pharmacotherapy on the risk of fall in inpatients III
Honsová, Tereza ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of the effect of pharmacotherapy on the risk of falls in inpatents III Author: Tereza Honsová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Falls are frequent and unwanted events happening in healthcare facilities. The falls have a multifactorial character. The prevention is the best way how to improve a quality of healthcare and a quality of the patient's life. All of the doctors, clinical pharmacists and nurses can help to realize it by cooperating with each other, working with professional information and by individual attitude to each patient. Objective: The aim of this study was to analyze the effect of the fall risk-increasing drugs to falls in hospitalized patients and to recommend the right interventions to prevent the fall. Methodology: For the analysation, classification and quantification of the fall risk-increasing drugs, drug related problems and interventions a special online database was created. All of the doctors, clinical pharmacists and nurses were collecting details about the pacients and about how the fall happened. Fall risk-increasing drugs and drug-related problems were then analyzed by clinical pharmacists. Potential interventions were suggested. Also other...
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Migraine and its treatment
Petríková, Andrea ; Jirkovský, Eduard (advisor) ; Červený, Lukáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmacology and Toxicology Supervisor: PharmDr. Eduard Jirkovský, Ph.D. Author: Andrea Petríková Title of Diploma Thesis: Migraine and its treatment Migraine is one of the primary headaches, manifested in repeated attacks of severe one-sided and throbbing headaches, usually lasting 4-72 hours. They are accompanied by one of the following symptoms: photophobia, phonophobia, odorophobia, nausea, vomiting. From one seizure to the next, the patient feels like a healthy patient. In my work I describe current pharmacotherapeutic procedures in the treatment of migraine. In the first part of the diploma thesis, I presented a literature review of migraines, which begins with the classification of headaches. I continue with the definition of migraine, history, classification of migraine, pathophysiology, prevalence and diagnostic criteria of migraine. In the second part I describe the different types of treatment with their procedures and the drugs that are used. Based on our knowledge of the pathophysiology of migraine, new drugs have been developed for the treatment of acute migraine attacks that target calcitonin gene-related peptide (CGRP) and serotonin 5-HT1F receptors. I describe their mechanism, which drugs have been...
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Bioinformatic aspects of nuclear receptors in pharmacotherapy
Škoda, Josef ; Pávek, Petr (advisor) ; Kollár, Peter (referee) ; Matoušková, Petra (referee)
IN ENGLISH LANGUAGE Candidate: Mgr. Josef Škoda Supervisor: Prof. PharmDr. Petr Pávek, PhD. Title of the doctoral thesis: Bioinformatical aspects of nuclear receptors in pharmacotherapy The liver plays a central role in energy homeostasis via processing post-prandial excess energy into storage molecules and reusing stored energy via gluconeogenesis during the fasting period. This tight energy balance is maintained by a myriad of regulating processes. Dysfunction of metabolic control is a key event of severe diseases in today's population, starting with obesity, insulin resistance, and metabolic syndrome, proceeding to end-stage complications in type 2 diabetes, whole organ malfunctions, or even tumor diseases. Master players in metabolic regulation are nuclear receptors (NR) activated by endogenous stimuli or scavenging for nutritional or toxicological signals. NRs regulate gene transcription activation and therefore maintain liver metabolic plasticity. In this thesis, modern molecular biology approaches were used to study ligands of NRs and the effects of their treatment. After the typical activation of a NR, hundreds of genes are regulated, which is beyond the ability to study with conventional biology methods. For this purpose, omics methods are an ideal solution. They are characterized by...
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Self-inflicted trauma in young people with in the context of behavioral disturbance
Kolaříková, Katarína ; Šotolová, Eva (advisor) ; Mlčková, Marie (referee)
TITLE: Self- inflicted trauma in young people with in the context of behavioral disturbance AUTHOR: Bc. Katarína Kolaříková DEPARTMENT: Department of special education SUPERVISOR: Doc. PaeDr. Eva Šotolová, Ph.D. ABSTRACT: This thesis solves two serious topics of special pedagogic. Behavioural disorders and self-harming behaviour. Self-harming behaviour is deliberate, conscious and often repetitive violation of physical integrity without intent to die. The work is divided into 11 chapters. The first are focused on behavioural disorders, self-harming behaviours, and crisis intervention. Other chapters deal with the goals, research questions and chosen method of treatment. The aim was to map the occurrence, factors and methods of self-harming and describe alternative techniques of reducing this behaviour. Qualitative research is used in this work - analysing the anamneses of individuals with behavioural disorders and interviews with ethopedic workers. The inquiry of documentation shows that self-harming behaviour is caused by negative effects of family and social environment. The most common methods include self-cutting of girls, fists and head pounding against the wall of boys. For alternative methods of reducing this behaviour, the staff of orphanages with schools agreed that the preferred method is...
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Multiple Sclerosis: Corticoid and Biological Therapy, Importance of Pedagogy in Rehabilitation
Rosová, Anna ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The submitted thesis deals with the theme of a neurodegenerative autoimmune disease, the sclerosis multiplex. Although this serious disease has become an object of intensive research in recent decades and there is an inexhaustible quantity of literature available, we haven't yet fully identified the causes of this disease as well as we haven't found such kind of effective treatment that would lead to the permanent recovery of patients. I focused my interest on two main spheres: first, the description and comparison of practices in terms of pharmacotherapy giving priority to its benefits to patients, second, the view of another important but not always appreciated part of therapy, physiotherapy or rehabilitation; the main point is studying of processes and actions from the pedagogical point of view.
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Recent Findings on the Pharmacotherapy of Methamphetamine Dependence: Potentially Suitable Substances for Methamphetamine Substitution
Oktábec, Zbyněk ; Gabrhelík, Roman (advisor) ; Minařík, Jakub (referee)
Charles University in Prague First Faculty of Medicine Study programme: Specialization in Health Care Branch of Study: Addictology PharmDr. Zbyněk Oktábec, Ph.D. et Ph.D. Recent Findings on the Pharmacotherapy of Methamphetamine Dependence: Potentially Suitable Substances for Methamphetamine Substitution Bachelor's Thesis Advisor: Mgr. Roman Gabrhelík, Ph.D. Prague, 2014 Abstract Methamphetamine has long been a lead drug of abuse among problem drug users on the Czech drug scene. At the moment, there is no worldwide effective pharmacological treatment of addiction on the methamphetamine/amphetamine-like substances. There have been found substances, with the greater or lesser success, from different ATC groups as well as some new substances, which some patients/clients could profit from. Nevertheless we still fail to find a widely effective pharmacotherapy of methamphetamine dependence, which would be efficacious and broadly applicable, i.e. as the substances in the treatment of opioid dependence. This work aims to present current information on substitution and/or craving reduction therapy in the treatment of methamphetamine dependence. This paper has the character of a research/review work and uses up-to-date data, not only in published articles and in the primary literature, but in ongoing clinical trials...
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