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Analysis of the effect of pharmacotherapy on the risk of fall in inpatients III
Honsová, Tereza ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of the effect of pharmacotherapy on the risk of falls in inpatents III Author: Tereza Honsová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Falls are frequent and unwanted events happening in healthcare facilities. The falls have a multifactorial character. The prevention is the best way how to improve a quality of healthcare and a quality of the patient's life. All of the doctors, clinical pharmacists and nurses can help to realize it by cooperating with each other, working with professional information and by individual attitude to each patient. Objective: The aim of this study was to analyze the effect of the fall risk-increasing drugs to falls in hospitalized patients and to recommend the right interventions to prevent the fall. Methodology: For the analysation, classification and quantification of the fall risk-increasing drugs, drug related problems and interventions a special online database was created. All of the doctors, clinical pharmacists and nurses were collecting details about the pacients and about how the fall happened. Fall risk-increasing drugs and drug-related problems were then analyzed by clinical pharmacists. Potential interventions were suggested. Also other...
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Analysis of utilisation and spontaneous adverse events reports related to human papillomavirus vaccines
Schrommová, Tereza ; Zimčíková, Eva (advisor) ; Kolmanová, Eliška (referee)
Analysis of utilisation and spontaneous adverse events reports related to human papillomavirus vaccines Author: Tereza Schrommová Supervisor: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University INTRODUCTION: HPV vaccination is one of the most effective types of prevention against the human papillomavirus infection that can lower the probability of its incidence up to 80-90 %. Besides the benefits of vaccination, there can also occur among many individuals certain risks and adverse effects. Spontaneous adverse events reports are used to identify these serious and unexpected adverse effects, their monitoring leads to increasing safety of therapy. Drug consumption is monitored to uncover the ratio of population exposure to certain drug during specific time in specific socioeconomic group. OBJECTIVE: The objective of this diploma was analysis of spontaneous adverse events reports of vaccines against the human papillomavirus that are registered in database of State Institute for Drug Control in the period from May 2007 to October 2017. Another aim of this work was to evaluate consumption of HPV vaccines in the Czech Republic in the period from 2006 to 2019 using data from State Institute for Drug Control again. METHODS:...
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The referral procedure as a tool for influence the regulatory status of medicinal product in EU.
Závodská, Gabriela ; Zimčíková, Eva (advisor) ; Fuksa, Leoš (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Mgr. Gabriela Závodská Consultant: PharmDr. Eva Zimčíková, Ph.D. Title of Thesis: The referral procedure as a tool for influence the regulatory status of medicinal product in EU. The referral procedure is very important possibility how the medical agencies in EU can influence the regulatory status of a medical product - change, suspend or revoke the registration. Our first aim was to describe the referral procedures defined in "The rules governing medicinal products in the European Union" - reasons for initiation, course and possible outcomes. One chapter deals with procedures concerning risk of venous and arterial thromboembolism in users of combined hormonal contraceptive. Our second aim was to observe the number of procedures during 2005-2014. We were interested in reason for initiation and outcomes of some procedures. We observed an increase in the number of procedures which are initiated from safety reasons on the basis of pharmacovigilance data.
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Analysis of Anticoagulant Utilization in the Czech Republic in the period from 2007 to 2016
Hochelová, Zuzana ; Zimčíková, Eva (advisor) ; Malý, Josef (referee)
Analysis of anticoagulant utilization in the Czech republic in the period from 2007 to 2016 Author: Zuzana Hochelová1 Supervisor: PharmDr. Eva Zimčíková, Ph.D.1 Consultant: PharmDr. Kateřina Malá, Ph.D.1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Anticoagulants are drugs that reduce blood clotting and prevent the formation of blood clots. In the Czech Republic - antagonists of vitamin K-warfarin, direct oral inhibitors of factor Xa-rivaroxaban, apixaban, edoxaban, direct oral inhibitors trombin - dabigatran, parenteral anticoagulants - heparin, low-molecular heparin, fondaparinux, oral and parenteral hirudin are used. Objective: The objective of this diploma thesis was to assess the consumption of oral and parenteral anticoagulants in the Czech Republic from 01. 01. 2007 to 31. 12. 2016, based on the data from the State Institute of Drug Control (SIDC). Methods: ATC/DDD methodology was applied. The research consisted of a retrospective analysis of the SIDC database. All oral and parental anticoagulants approved in the CR were included in the study. Drug utilization was calculated as number of defined daily doses per thousands of inhabitants per day (DID). The data on the number of residents was acquired from...
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Use of inhaled drugs in obstructive pulmonary diseases
Obertová, Nikola ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Use of inhaled drugs in obstructive pulmonary diseases Author: Nikola Obertová 1 Tutor: Josef Malý 1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objectives: Chronic respiratory diseases are emerging health problem. The administration of the medication is mostly performed by the process of inhalation. Therefore, a proper inhalation technique plays a crucial role in symptom reduction and achievement of adequate control over the disease. The aim of the thesis was partly to assess the level of inhalation technique in elderly patients in nursing home settings, partly to evaluate the knowledge of nurses and their role in advice provision related to the proper inhalation technique. Methods: The data were collected from June to September 2016 from 18 nursing homes located in South Wales (Great Britain). The study was realized in two arms. The evaluated group (first arm) was composed of patients (residents) with having asthma bronchiale or chronic obstructive pulmonary disease diagnosed and being older than 65 years. Second arm consisted of nurses responsible for giving advices about inhalation technique to the residents. Nursing home visits were composed of three parts. First one was a controlled interview based on the...
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Patient Perspective of Medication Information Desired
Kalaitzidis, Panagiotis ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Title: Patient perspective of medication information desired Student: Kalaitzidis Panagiotis Tutor: Jiri Vlcek Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Even from the decade of 1970, patients wanted more information about drugs and did not want to be so depended on the information the physician provided them. Today patients are more than ever informed about their disease and the available and appropriate treatment, due to the high volume of information that can be acquired through the Internet. The traditional role of pharmacists was the provision of medicines to the population. However, nowadays, this role has been changed so as to include other tasks, such as management of prescribed medicines, and promotion of health, since pharmacists can serve as a source of expertise knowledge to the customers. Due to the fact that there is no relevant research for the case of Greek patients, this pilot research could help to fill this gap, by trying to find out what kind of information patients want to know about medicines in several pharmacies in Greece. Aim: The aim of this research is to examine what kind of information patients want related to medicines. More precisely, this research will try to identify the type of...
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Attitudes and beliefs on HPV infection and vaccination
Blašková, Dominika ; Zimčíková, Eva (advisor) ; Pokladníková, Jitka (referee)
ATTITUDES AND KNOWLEDGE OF HPV INFECTION AND VACCINATION Author: Dominika Blašková Supervisor: PharmDr. Eva Zimčíková, Ph.D. INTRODUCTION Human papillomavirus (HPV) is a DNA virus. The virus causes benign and malignant diseases of men and women such as laryngeal papillomatosis, genital warts, oropharyngeal carcinoma, cervical cancer, penile cancer and anus cancer. HPV can be prevented by appropriate precautionary measures. The main preventative method is vaccination against HPV. Besides vaccination, regular screening is necessary to detect premalignant changes on time. AIMS The aim of the theoretical part of the diploma thesis was to summarize the information about HPV, the diseases caused by human papillomavirus and vaccination against HPV, the main preventive measure. The primary aim of the practical part was to find out the level of HPV awareness among girls and boys and diseases caused by HPV. The secondary aim of the practical part was to find out opinions on HPV vaccination and determine the rate of vaccination against HPV among young people in Slovakia. METHODS The method of quantitative research taken in the form of a questionnaire was used in the diploma thesis. The survey was realized at two secondary schools in Svidník, Slovakia. The age range of respondents was 15-20 years. The data...
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ANTIBIOTIC CONSUMPTION ANALYSIS BASED ON HEALTH INSURANCE COMPANY DATA
Buriánková, Lenka ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
ANTIBIOTIC CONSUMPTION ANALYSIS BASED ON HEALTH INSURANCE COMPANY DATA Student: Buriankova L. Tutor: Vlcek J., Dept. of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: Overuse and misuse of antibiotics leads to increased resistance of microorganisms to antibiotics. There is a risk we will not have antibiotics effective against pathogenic microorganisms in future. It is therefore very important to make guidelines for rational prescribing and use of antibiotics. Aim: Analyze antibiotic consumption data package collected in given period depending on consumer age or sex. Analyze which group of doctor prescribes antibiotics in most cases. Analyze the most prescribed substances depending on different expression of consumption and compare obtained data with available data. Methods: Source of data is a database of employment insurance. The number of insurance clients was 129 699 in 2006 and 131 876 in 2007. Antibiotic use was evaluated, namely the group J01 of ATC system - Antibacterial drugs for systemic use. Data cover years 2006 and 2007. AISLP-CR, version 2008.4 is a database used for searching information about different drugs and substances. Obtained data were summarized in a database in Microsoft Excel. ATC / DDD system was...
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Adherence to treatment in patients after kidney transplantation
Vaňková, Barbora ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Adherence to Treatment in Patients after Kidney Transplantation Author: Barbora Vaňková Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Kateřina Ládová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Kidney transplantation (KT) is the best treatment option for patients with end- stage renal disease. However, despite its numerous benefits it requires a lifelong medical regimen of immunosuppressive treatment (IS) with a special emphasis on a strict medication adherence (MA). The objective of our study was to analyse MA in KT outpatients. We also intended to analyse non- adherence as one of the drug-related problems. Furthemore, we focused on analysis of the main self- management tasks. Methods: The prospective cross-sectional study was undertaken in one year period from March 2016 to March 2017 at the Haemodialysis Centre in the Teaching Hospital Hradec Králové. Patients ≥ 18 years old and at least 3 weeks after KT were addressed within their regularly scheduled visit to the nephrologist. Structured interview was performed by pharmacist to determine patients' self-reported MA to IS using validated Czech version of Medication Adherence Report Scale (MARS-CZ). In addition, patients were interviewed about other...
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Drugs and people III.
Hudcová, Petra ; Práznovcová, Lenka (advisor) ; Zimčíková, Eva (referee)
15. SUMMARY DRUGS AND PEOPLE III. Author: Hudcová Petra (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Tutor: PharmDr. Práznovcová Lenka, Ph.D. (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Backgroud: Availability of drugs is limited by many factors. Economic factors are one of the most important. The financial participation of patients on drugs is one of basic metod for regulation the costs in health. Increase the financial participation of patients on drugs and reduction stae costs on pharmacotherapy (in cases where it's possible in terms of availability) may be increased the availability of more expensive pharmacotherapy. Aim of study: The aim of the theoretical work is mapping the current situatian in the Czech republic in relation to the price of drugs. Practical part of the work is focused on the evaluation research conducted among pharmacy clients in pharmacy "Koruna" located in West Bohemian town Ostrov. Methods: The survey was conducted through questionnaire "People and drugs". This questionnaire was created on Department of social and clinical pharmacy, Faculty Of Pharmacy in Hradec Králové. Data was obtained from clients pharmacy in term of November - December...
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