National Repository of Grey Literature 156 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Analysis of antibiotic administration in prophylaxis I.
Domecký, Petr ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
8 Abstract Analysis of antibiotic administration in prophylaxis I Author: Petr Domecký Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Lucie Hauschke, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Antibiotic prophylaxis (AP) plays an important role in reduction of surgical site infection (SSI). It is the administration of an eligible antibiotic or chemotherapeutic (ATB) in a single dose, usually 30 minutes before surgery, followed by two to three doses during or after the surgery, regarding the selected ATB and the surgical procedure. The aim of this work was to analyse the AP in surgical procedures at the Masaryk Hospital in Ústí nad Labem (MNUL) in the context of the MNUL guideline (DP) and the research on available AP work. Methods: A cross-sectional observational study ran from January 2018 to March 2018 in surgical departments at MNUL. The study included patients aged ≥ 18 years who underwent surgery in a defined period (5 February 2018 to 9 February 2018) and gave their consent to the study. The practicability of the study was verified by a pilot part. Initially, a research of published studies concerning AP was carried out which provided outputs for AP establishment (PPA). Subsequently, a form for...
Precisation prediction of therapeutic response to cancer immunotherapy
Novotná, Jana ; Malý, Josef (advisor) ; Čečková, Martina (referee)
Precisation prediction of therapeutic response to cancer immunotherapy Author: Mgr. Jana Novotná Consultant: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharamcy Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Over the last few years, anticancer immunotherapy has increasingly become an important agent in treatment of oncologic patients. The aim of this thesis was to assess the clinical parameters and to find any biological markers that would predict efficacy of pembrolizumab and nivolumab. Methods: The research was based on retrospective data analysis of patients treated with pembrolizumab or nivolumab during 2015-⁠2020 at Oncology Clinic of General Uviersity Hospital in Prague. The patients were divided into responder or non-responder groups based on their treatment response. Subsequently the analysis of clinical parameters, adverse events, panel gene sequencing of tumor DNA and RNA was performed. Finally, the obtained data were tested to find any correlations between biological markers and the treatment outcomes by the descriptive statistic method. Results: The data of 70 patients (60 % men, between 42-⁠86 years old) were analysed. The most frequent patient profile was man in age 70-⁠79 years with non- small cell lung cancer diagnosis. In...
Analysis of the therapy in patients with juvenile idiopathic arthritis
Procházková, Martina ; Malý, Josef (advisor) ; Rozsívalová, Petra (referee)
Abstarct Analysis of the Therapy in Patients with Juvenile Idiopathic Arthritis Author: Martina Procházková Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Methotrexate (MTX) is an effective and safe drug used for the treatment of juvenile idiopathic arthritis (JIA) and is well-known like a golden standart in the treatment of this serious illness. The aim of this study was analysis of therapy in patients with JIA focusing on MTX and faktors affecting its intolerance. Methods: The study was undertaken from January 2017 to February 2018 at the Department of Paediatrics and Adolescent Medicine, 1st Faculty of Medicine, Charles University in Prague. Patients younger than 18 years old, who have become ill with JIA for the first time or repeatedly between years 2015-2017 and were treated by MTX were included in this study. The prevalence of MTX intolerance was measured by "Methotrexate Intolerance Severity Score" questionaire every 3 months during regular rheumatological examinations. Simultaneously, medical records were reviewed. Data analysis was performed by means of descriptive statistics, correlation dependence and statistical signifikance of dependence was assessed with statistical two-choice...
Identification and analysis of therapy used by pregnant women II.
Vachudová, Eliška ; Malý, Josef (advisor) ; Babica, Jan (referee)
Identification and analysis of therapy used by pregnant women II. Author: Eliška Vachudová1 Tutor: PharmDr. Josef Malý, Ph.D.1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objective: Taking medication during pregnancy often implies higher risk of adverse effects for pregnant woman as well as for the foetus. In the Czech Republic, there is not enough information for rational drug taking during gravidity yet. The purpose of the practical part was to identify and analyze therapy used by pregnant women by questionnaires, in which respondents could show their knowledge and awareness of over-the-counter drugs, medical devices, food supplements and herbal and homeopatic remedies. Methods: The data collection lasted from August 2017 to March 2018 and was performed in the form of questionnaires at the Domažlice Hospital, Department of Gynecology and Obstetrics. Nurses played a vital role to distribute the questionnaires and instruct every newly admitted woman how to fill them. The questionnaire was anonymous, contained 50 questions of open, semi-open and closed types and included introduction letter with the entrance criteria. After filling in, they were transformed into electronic ones using Google Forms. Collected data were...
Analysis of drug-related problems in a health facility IV.
Šubrtová, Linda ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of drug-related problems in a health facility IV. Author: Linda Šubrtová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Increasing use of drugs leads to a growing risk of occurence of drug-related problems. These problems can often endanger patient's health and increase the economic cost of the treatment. However, many of these problems can be prevented by controls and collaboration of all health care subjects. Objective: The aim of this work was to carry out a revision of pharmacotherapy in a rehabilitation health facility and to analyse acquired drug-related problems. Methodology: The collection of data took place from 13 to 15 February 2017 in health facility in the Czech Republic. The review of pharmacotherapy was performed by a three-member team (clinical pharmacist, pharmacist, work researcher). The data obtained from the provided medical records were recorded into the database, which was prepared for the purpose of the pharmacotherapy review. Recorded were: the patient's age and sex, allergic, family, work, social and personal history, physical and laboratory examinations and complete pharmacotherapy, which included over-the-counter drugs and dietary supplements, including dosage...
Identification and analysis of therapy used by pregnant women III.
Cimbálová, Edita ; Malý, Josef (advisor) ; Babica, Jan (referee)
Identification and analysis of therapy used by pregnant women III. Author: Edita Cimbálová Thesis Supervisor: PharmDr. Josef Malý, Ph.D. Thesis Consultant: Mgr. Pavel Horký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and purpose: Therapy of pregnant women is accompanied by a variety of changes that need to be accounted for. The purpose of the theoretical part was to summarise available information in selected health issues of pregnant women. The purpose of the practical part was to identify and analyse the therapy used during pregnancy and the attitudes, opinions and awareness of women after delivery about over-the- counter drugs, medical devices and other forms of complementary and alternative medicine. Methods: The data were collected at the maternity ward of Jičín Hospital from November 2017 to February 2018 via questionnaires. The questionnaire contained information about the study and it was consisted of 50 questions of open, semi-closed and closed format focused on health issues during pregnancy, attitudes and opinions about homeopathy, herbal medicine, vaccination and the way to get informations during pregnancy. The collected data were transfered into an electronical form and subsequently analysed by methods of...
Analysis of drug-related problems in a health facility IV.
Šubrtová, Linda ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of drug-related problems in a health facility IV. Author: Linda Šubrtová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Increasing use of drugs leads to a growing risk of occurence of drug-related problems. These problems can often endanger patient's health and increase the economic cost of the treatment. However, many of these problems can be prevented by controls and collaboration of all health care subjects. Objective: The aim of this work was to carry out a revision of pharmacotherapy in a rehabilitation health facility and to analyse acquired drug-related problems. Methodology: The collection of data took place from 13 to 15 February 2017 in health facility in the Czech Republic. The review of pharmacotherapy was performed by a three-member team (clinical pharmacist, pharmacist, work researcher). The data obtained from the provided medical records were recorded into the database, which was prepared for the purpose of the pharmacotherapy review. Recorded were: the patient's age and sex, allergic, family, work, social and personal history, physical and laboratory examinations and complete pharmacotherapy, which included over-the-counter drugs and dietary supplements, including dosage...
Analysis of antibiotic administration in prophylaxis II.
Bobčíková, Martina ; Malý, Josef (advisor) ; Rozsívalová, Petra (referee)
Analysis of antibiotic administration in prophylaxis II Author: Martina Bobčíková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Anna Patková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: The term antibacterial prophylaxis (AP) refers to antibiotic (ATB) administration in prevention of surgical site infection (SSI). There are many factors in population which can potentially raise the risk of the incidence of SSI. The maintenance of basic rules of the AP and knowledge, influence and timely elimination of risk factors of SSI are the most important measures which can reduce a number of postoperative SSI. The aim of this study was to analyze antibiotic administration in prophylaxis in the local hospital in the Czech Republic and compare the results to well known international guidelines (ASHP-G) and latest scientific knowledge (LSK). Methods: The cross-sectional study was conducted in October 2019. During the period from 2nd to 23rd October, the data of surgeries and used AP were collected. The patients who passed the entry criteria have been included in this study. Into prepared form, patient's identification, agreement, diagnosis, surgery type, operation date, the beginning and the end of surgery,...
Analysis of antibiotic administration in prophylaxis I.
Domecký, Petr ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
8 Abstract Analysis of antibiotic administration in prophylaxis I Author: Petr Domecký Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Lucie Hauschke, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Antibiotic prophylaxis (AP) plays an important role in reduction of surgical site infection (SSI). It is the administration of an eligible antibiotic or chemotherapeutic (ATB) in a single dose, usually 30 minutes before surgery, followed by two to three doses during or after the surgery, regarding the selected ATB and the surgical procedure. The aim of this work was to analyse the AP in surgical procedures at the Masaryk Hospital in Ústí nad Labem (MNUL) in the context of the MNUL guideline (DP) and the research on available AP work. Methods: A cross-sectional observational study ran from January 2018 to March 2018 in surgical departments at MNUL. The study included patients aged ≥ 18 years who underwent surgery in a defined period (5 February 2018 to 9 February 2018) and gave their consent to the study. The practicability of the study was verified by a pilot part. Initially, a research of published studies concerning AP was carried out which provided outputs for AP establishment (PPA). Subsequently, a form for...
Photoprotection in patients after kidney transplantation
Hajšelová, Zuzana ; Malý, Josef (advisor) ; Kolmanová, Eliška (referee)
Photoprotection in Patients after Kidney Transplantation Author: Zuzana Hajšelová Tutor: doc. PharmDr. Josef Malý, PhD. Consultant: Mgr. Barbora Vaňková Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradci Králové, Charles University Introduction and aims: Patients after kidney transplantation (KT) are in a higher risk of developing skin cancer as a result of lifelong immunosuppressive (IS) therapy. Thorough photoprotection is therefore recommended. The aim of this study was to determine patients' awareness and level of photoprotection and to analyse selected risk factors for skin cancer development in patients after KT. Methods: The cross-sectional study was undertaken from 15th April to 31st December 2019 at the Haemodialysis Centre in the Teaching Hospital Hradec Králové. Patients included in this study were above 18 years old, who visited Haemodialysis Centre in the defined period. The data was collected from the patients' medical documentation (e.g. occurrence of skin cancer and skin cancer type, current IS) and from the written version of questionnaires (e.g. phototype, sun exposure, photoprotection). The data was analysed using descriptive statistics. Results: There were 410 KT patients in regular care of the Haemodialysis Centre, 361 fulfilled the questionnaire (88.0...

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See also: similar author names
21 MALÝ, Jan
8 Malý, Jakub
21 Malý, Jan
4 Malý, Jaroslav
10 Malý, Jiří
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