National Repository of Grey Literature 47 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Speciální druhy pečiva a možnosti inovace receptur
Janečková, Šárka
Thesis is focused on the production of baked goods for population groups suffering from diseases that require special dietary therapy. Subject of the literature research was to get acquainted with three of the most serious of them - celiac disease, Crohn's disease and diabetes and a consequent summary of the individual dietary requirements related to the diseases. The aim was to create an overview of basic, innovative and non-traditional ingredients suitable for the production of special baked goods for people suffering from these diseases. Practical part of the work was based on the development of six recipes for the production of bakery products using non-traditional ingredients, followed by successful execution of baking expe-riment, instrumental analysis of samples and sensory evaluation of the products. The baking experiment resulted in 3 groups of baked goods - gluten-free, non-residual and low-carbohydrate. The best volume, firmness and sensory properties were achieved in the gluten-free bakery products, which were very similar to the conventional bakery products and were also judged to be the most sensory ac-ceptable based on the sensory questionnaires. For the other two groups of bakery products, the results of the measurements and sensory evaluation were not very sa-tisfactory, although very interesting crust and crumb colours were achieved in the-se samples due to the used ingeridents.
Histopathological predictors of clinical course severity and development of surgical complications in children with inflammatory bowel diseases
Fabián, Ondřej ; Zámečník, Josef (advisor) ; Daum, Ondřej (referee) ; Karásková, Eva (referee)
The aim of the presented thesis is to summarize a benefit and limitations of histopathological assessment of bioptic samples for diagnostics and prediction of complicated course of the disease in children with inflammatory bowel diseases (IBD). We would also like to outline a potential benefit of more sophisticated histopathological methods in these domains. In the first phase of our research, we aimed at correlation of microscopical disease activity in children with Crohn's disease (CD) with activity assessed endoscopically and clinically. We also examined a histopathology as a possible predictor of development of complications, since previous works on adult cohorts indicate only a limited predictive value of microscopy. Our study confirmed this premise also for pediatric patients, since histopathological findings correlated weakly with endoscopy, didn't correlate with clinical activity of the disease and did predict none of the defined complications. On the other hand, endoscopy appeared to be a reliable predictor of complicated course of the disease. In the next part of our research, we were searching for other, more precise methods of assessment of histopathological disease activity that could serve as predictors of complications. We focused at immunohistochemical assessment of tissue...
Awareness of children from selected schools about Crohn's disease
Mejstříková, Anna ; Hanušová, Jaroslava (advisor) ; Váchová, Alena (referee)
In my bachlors thesis I decided to focus on Crohn's disease. In the theoretical part, I dealt with the basic information about the disease, in which I tried to summarize the important information. For example, I focus on etiology, clinical picture, treatment and quality of life of patients. Then, in the practical part, I discuss the knowledge of children. These knowledge was collected by an anonymous survey using questionnaires. The questionnaires were distributed among the sixth, seventh, eighth and ninth grades in the primary school in Uhlířské Janovice and in the Gymnasium in Kolín. My aim was to find out whether the children were informed about the disease and if so, to what extent. For a better overview I chose two sub-objectives and one main objective. In the first sub-objective, I concentrate on basic information about Crohn's disease and supposted that less than 50% of the children would not be aware of the existence of Crohn's disease at all. This assumption held true. Only 62 children (31.3%) had heard of the disease. In the second sub-objective, I focused on knowledge. Here, I assumed that children from the grammar school would be more aaware of Crohn's disease than children from the primary school. This assumption was not fulfilled. The primary school children has an overall success...
Dietary habits of patients suffering from IBD
Metličková, Aneta ; Kohout, Pavel (advisor) ; Šimková, Simona (referee)
This diploma thesis titled "Dietary habits of patients suffering from IBD", deals with specifics of said diseases as well as nutrition of these patients. The theoretical part touches on Crohn's disease and ulcerative colitis, it lists characteristics, epidemiology, possible complications and treatments of these diseases. There is a detailed description of usage of medical nutrition therapy and various diets that use to be recommended to these patients. It also presents medical nutrition therapy as an indispensable element of the process of treating these diseases. The 4 main goals I set for my thesis were as follows: to map eating habits of respondents suffering from IBD; to compare eating habits of patients suffering from IBD with those of healthy respondents; to compare eating habits of patients suffering from CD with eating habits of patients suffering from UC and lastly - to find out where respondents get their information on their disease and nutrition from. The research consisted of 12 respondents in total of which half were patients suffering from IBD and the other half were healthy individuals. The group of respondents suffering from IBD consisted of 3 CD patients and 3 UC patients. To obtain the data I used a semi-structured interview as well as dietary recall. I chose to interview only...
Tcf4 transcription factor in the intestinal epithelium renewal and pathology
Müllerová, Tereza ; Janečková, Lucie (advisor) ; Vávra, Jiří (referee)
TCF4 (T-Cell Factor 4, sometimes also TCF7L2) is an important effector of the canonical Wnt signalling pathway. The transcription factor is produced in many different isoforms with tissue-specific expressionand diametricallyopposing functions.In the intestine,TCF4 is a key factor in epithelial regenerationandmaintenance of stem cell homeostasis. Its depletion causes loss of the proliferatingcrypt compartment and complete breakdown of the intestinal mucosal architecture. The processes in which it acts are therefore vital and must be strongly regulated by the Wnt signalling pathway. Disturbances in TCF4 expression or alternative splicing often lead to a wide range of complex pathologies such as colon cancer, ileal Crohn's disease and type 2 diabetes mellitus.
Calprotectin determination in patients with autoimmune disease.
The bachelor thesis deals with autoimmune diseases of GIT and laboratory determination of calprotectin by chemiluminescence method. In the theoretical part I focused on individual diseases, their description and treatment options. The main part of the thesis is devoted to the laboratory diagnosis of calprotectin from stool. I statistically evaluated 300 samples. And further I compared the method with other p-ANCA and ASCA methods.
Střevní mykobiom asociovaný s diagnózou zánětlivého střevního onemocnění založený na tkáňových biopsiích
This thesis reveals results of NGS mycobiome analysis from formalin-fixed, paraffin-embedded samples of Crohn's disease, ulcerative colitis patients and healthy controls, divides fungal genera into three experimental groups, determines their affiliation to health and disease, suggests fungal genera interactions, and shows specific fungal genera related to the diagnosis.
Nutrition care in the treatment of pediatric patients with Crohn's disease
ČADOVÁ, Andrea
This bachelor thesis deals with the nutrition care of pediatric patients with Crohn's disease. The main goal is to find out whether the patients' parents and the patients themselves are sufficiently informed about nutrition and if Crohn's disease had impact on the eating habits of the children. The theoretical part is focused on the current epidemiology, etiopathogenesis, clinical presentation, diagnostic procedure and treatment options. It is also focused mainly on clinical nutrition and dietary measures. For this research, I chose a qualitative approach, which was attended by ten children respondents and ten mothers. The practical part is divided into three subchapters. The first of them is devoted to case reports with basic information about patients obtained from personal and nutritional anamnesis. The second part evaluates the answers of the mothers of the respondents and the respondents themselves to the questions asked during the semi-structured interviews. The last part is devoted to the evaluation of eight week-long menus and two 24-hour calls. This research has shown that parents and pediatric patients are well informed about the diet of Crohn's disease but some of them think that not all the questions they had were answered. Then they can search answers for their unanswered questions on non-professional websites. For most respondents, Crohn's disease did not have a particularly significant impact on their eating habits. Reduction of the number of fried meals and fast food was the most common change in the patients' lives.
Management of multidisciplinary care in patients with inflammatory bowel disease.
The diploma thesis deals with the management of multidisciplinary care for patients with inflammatory bowel diseases and is divided into a theoretical and a practical part. The theoretical part focuses on inflammatory bowel diseases, their characteristics, etiology and pathogenesis, diagnosis, treatment and psychosocial side of the disease. Another part of the theoretical part is the characteristics of management in nursing, nursing managers, the nursing profession itself, the multidisciplinary team in health care, the issue of competencies and the need for a multidisciplinary approach in the case of inflammatory bowel disease. The first aim of the thesis was to map the role of individual medical and non-medical staff involved in the care of patients with inflammatory bowel diseases, the second goal to find out how cooperation among these workers work and the third objective to identify dispensaries in patients with IBD outside hospital care. For the empirical part of the diploma thesis, a qualitative research survey was chosen, and semi-structured interviews were used as the method of data collection. Five variants of interviews were created, for nurses, doctors, nutrition therapists, psychologists and patients diagnosed with inflammatory bowel diseases. The research was conducted at the Clinical and Research Centre ISCARE in Prague and at the General University Hospital in Prague with the prior consent of the management of these facilities, except for patients who were contacted through patient groups and a psychologist who worked in his private outpatient facility. Based on interviews with nurses, doctors and a nutritional therapist, we were able to find out that as far as IBD centres are concerned, care is really interconnected and individual experts work as a multidisciplinary team led by doctors of various specialties, nurses, ostomy nurse, nutritional therapist. and a social worker. An exception is the representation of a psychologist, who unfortunately is not part of the team and there may be a problem with his / her availability, which was pointed out by some of the interviewees in the interviews. From the results of the research survey, we also managed to find out that patients have various options for better management of the disease, which are most often recommended to them by their attending physicians, but also by nurses. Nurses working in IBD centres are well versed in this issue and know the supportive options for patients with IBD. However, a problem in cooperation was found and appeared on the part of nurses, who in some cases take a passive attitude to education from an ostomy nurse, who is also an important member of a multidisciplinary team. Furthermore, based on research, we found that patients with IBD are often anxious and may have trouble trusting the nursing staff, so the main task of the nurse caring for such patients is to be more aware of these diseases, to know the supportive options, and to be able to educate clients. Respecting and understanding cooperation with other professionals are is important.

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