National Repository of Grey Literature 141 records found  1 - 10nextend  jump to record: Search took 0.11 seconds. 


Drugs as the threat to international security: Case study of Colombia-USA relations
Kolomazník, Filip ; Rolenc, Jan Martin (advisor) ; Demková, Marcela (referee)
The issue of drug trafficking is, for most societies, the actual topic. The international security is threatened every day in many different ways due to the transnational organized crime, which is a natural result of the need of a drug producer to sell the product to an end user, usually in a different country. The aim of this work is to analyze different types of threats that drug trafficking brings. The threats will be divided into four basic sectors according to Swanstrom's concept, which is based on the Copenhagen School. These sectors are: political, economic, social and military. The analysis will be performed on the case study of two specific countries, Colombia and the United States.

The Economic Consequences of Organized Crime
Kunt, Lukáš ; Polišenský, Miroslav (advisor) ; Pavel, Pavel (referee)
Summary This thesis deals with the significance of the threat that organized crime poses to society. The aim is to provide an overview of its present forms and economic impact. In the theoretical part, there is an outline of basic terms associated with organized crime, its traditional and new forms, the most influential organized crime groups and their history regarding the Czech Republic and the EU and institutions that fight them. The empirical part focuses on the issue of illegal drugs. Drugs smuggling and illegal drug trade are defined from the perspective of criminology. Using addictology and police statistics, the features of illegal drug market are described. Comparing various facts, the crackdown on illegal drugs in the Czech Republic and the EU is analysed, and from statistical data - applying mathematical methods - the value of illegal drug market is estimated. Economic impact of chosen forms of organized crime is described by the assessment of their share in GDP and economy in general. In the conclusion of this thesis, some measures that could reduce the social and economic impact are drawn.

The simulation of effect of membrane channel block by propafenone on electrical activity on human atrial cells
Brožková, K. ; Pásek, Michal ; Šlichta, J.
The main aim of this study is to explore the effect of propafenone on suppression of irregular excitations in human atrial cell. A program was designed that contains the computational model of electric activity on human atrial cells and the mathematical model of interaction of propafenone with INa-channels. This integrated model can served for simulations of the drug effects.

Phase II biotransformation of NSAID flobufen
Babú, Yogeeta ; Wsól, Vladimír (advisor) ; Nobilis, Milan (referee) ; Kuchař, Miroslav (referee)
Xenobiotic chemicals are chemicals foreign to life that are usually derived synthetically or from an abiotic process. The synthetic xenobiotic chemicals are often of enormous value to human society and are usually the majority of the chemicals in such important groups of substances as petrochemicals, pesticides, plastics and pharmaceuticals, where the term drug is usually applied when referring to xenobiotics. Biotransformation is a major mechanism for drug elimination, as they undergo biotransformation after they enter the body. Biotransformation, which almost always produces metabolites that are more polar than the parent compound, usually terminates the pharmacologic action of the parent drug and, via excretion, increases removal of the drug from the body. However, other consequences are possible, including similar or different pharmacologic activity, or toxicological activity. The routes by which drugs may be biotransformed are many and varied and include oxidation, reduction, hydrolysis and conjugation reactions, among others. It is important that these pathways are understood, as the route of metabolism of a drug can determine its ultimate pharmacological or toxicological activity. Drug biotransformation is divided into two phases: Phase I, or functionalisation reactions and Phase II, or conjugative...

Prevention of atherosclerotic cardiovascular diseases
Pavlásek, Karel ; Tilšer, Ivan (advisor) ; Vopršalová, Marie (referee)
Prevention of Atherosclerotic Cardiovascular Diseases Student: Karel Pavlásek Tutor: Doc. MUDr. Ivan Tilšer, Csc. Department of Pharmacology and Toxicology Pharmaceutical Faculty in Hradec Králové The Charles University in Praque, Czech Republic Theme: The research is particularly focused on Prevention of Atherosclerotic Cardiovascular Disease Objective: The purpose of the Thesis is to summarize briefly contemporary attitude to the prevention of cardiovascular disease. Methods: Data processing and research.The information gathered for the purpose of the Thesis are from Czech, foreign and internet sources. Results: The purpose of the Thesis is to summarize up to date attitude to the cardiovascular disease, especially to the ischemic heart disease. It is focused on prevention and pharmacological therapy. The pharmacological therapy is divided into therapy that leads to decrease of mortality and into therapy which might cause relief, but where any influence on mortality exists. Especially drugs that decrease mortality is the significant part of prevention. With their therapeutic effect we can ensure higher standard of living of the patients. Conclusion: I have tried to describe the attitude of scientific society to the ischemic heart disease.

The market for narcotics: Policy and Theory
Strnadová, Iveta ; Šťastný, Daniel (advisor) ; Janíčko, Martin (referee)
The content of this work is analysis of black market with drugs to determine how and to what extent the market can be eradicated. In the first part of my work I define the black market, analyze the basic causes of origin and its consequences for society. In the following section I examine what measures the governments do in this area. Furthermore, I focus on the views and recommendations of economists, and finally make a comparison of their recommendations with the implementation of policies in this area.

Plants of transformations: Using of plant hallucinogens by mexican indians in Oaxaca and by mestices in Peru
Horák, Miroslav ; Halbich, Marek (advisor) ; Komárek, Stanislav (referee)
This diploma thesis compares the use of natural hallucinogens by native groups of Mexican and Peruvian inhabitants from the cultural-ecological point of view. The basis of the thesis is an ethno-botanical analysis of the particular plant species containing this type of psychoactive substances, an anthropological interpretation of shamanism and a description of the particular rituals focusing especially on their curative function. Attention is also paid to artistic displays of shamans and healers. In the end of the thesis the ritualised way of using hallucinogens is confronted with the attitude to drugs of the present society.

Stem cells and therapy of brain and spinal cord injury
Syková, Eva ; Jendelová, Pavla ; Růžičková, Kateřina ; Machová-Urdzíková, Lucia ; Lesný, Petr ; Hampl, Aleš ; Dvořák, Petr
Our studies demonstrate the potential of SC as a therapeutic tool in the treatment of injury and degenerative diseases, explain the effects of certain drugs on neurogenesis and regeneration and show that there may be various ways in which SC may interact with the host CNS tissue.

Alcohol consumption and prevention of dependence in CR and France
Jandová, Petra ; Křížová, Eva (advisor)
Despite its social tolerance alcohol remains the drug of all consequences of harmful drinking . In developed European countries is cause 8-10 % of disease and injury. It brings the costs associated with health care and health insurance. Harmful effects of alcohol tend to pronounced in disadvantaged social groups , and therefore contribute to inequalities in health. However, direct injury to constitute a share any negative consequences. Alcohol consumption has a negative impact on economic development and society as a whole. For these reasons, the fight against harmful and hazardous consumption as a priority in public health programs many Member States and the EU as a whole. Czech Republic and France represent two completely different sociocultural environment. Residents have different eating habits, different lifestyles and different degree of tolerance to consume alcoholic beverages. They differ in the extent of individual consequences of harmful use and, therefore, procedures and objectives alcohol policy. Based on the statistical data on consumption , consequences and prevention measures can assess the gravity of the situation in both countries and compare problems of excessive consumption of health and socio-economic viewpoint. In this thesis , I used the large Czech and world database especially...