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	Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling) Pásek, Michal ; Šlichta, J. The restitution properties of cardiac action potential were shown to be important determinants of stability of reentrant arrhythmias. The restitution hypothesis states that steeply sloped restitution curves (relations between action potential duration and preceding diastolic interval) induce unstable wave propagation that results in wave break, the event that leads to fibrillation. In this contribution we try to explore the effect of modulation of membrane channel conductuvities on electrical restitu**n curves by means of computer modelling. Detailed record
	The quantitative exploration of refractory period in human atrial cells Brožková, K. ; Pásek, Michal ; Šlichta, J. The refractory period of cardiac cell plays a significant role in process of suppression of cardiac arrhythmias. The aim of this study is to explore the refractory period of human atrial cells. The method used in this work is based on quantitative modelling. Detailed record
	Computational model of cardiac cell contraction Šlichta, J. ; Pásek, Michal ; Brožková, K. Předmětem příspěvku je návrh modelu kontrakce srdečních buněk. Model popisuje procesy vedoucí k interakci kontraktilních bílkovin aktinu a myozinu a je pokračováním práce jejíž cílem je sestavení celkového modelu vazby excitace-kontrakce. Detailed record
	The simulation of effect of membrane channel block by propafenone on electrical activity on human atrial cells Brožková, K. ; Pásek, Michal ; Šlichta, J. The main aim of this study is to explore the effect of propafenone on suppression of irregular excitations in human atrial cell. A program was designed that contains the computational model of electric activity on human atrial cells and the mathematical model of interaction of propafenone with INa-channels. This integrated model can served for simulations of the drug effects. Detailed record
	Mathematical modelling of cardiac cell contraction Šlichta, J. ; Pásek, Michal This paper contains a proposal of model of cardiac cell contraction, which describes the processes leading to interaction of contractile proteins actin and myosin. Based on model published by D. A. Smith [4] a J. Neumann [1] a five-state model was created that is described by means of nine nonlinear differential equations Detailed record

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