Original title:
The simulation of effect of membrane channel block by propafenone on electrical activity on human atrial cells
Authors:
Brožková, K. ; Pásek, Michal ; Šlichta, J. Document type: Papers Conference/Event: Conference of the Czech Society of biomechanics with international participation Biomechanics of man 2000, Olomouc (CZ), 2000-11-24 / 2000-11-25
Year:
2000
Language:
eng Abstract:
The main aim of this study is to explore the effect of propafenone on suppression of irregular excitations in human atrial cell. A program was designed that contains the computational model of electric activity on human atrial cells and the mathematical model of interaction of propafenone with INa-channels. This integrated model can served for simulations of the drug effects.
Keywords:
cardiac cells; propafenone; quantitative modelling Project no.: CEZ:AV0Z2076919 (CEP) Host item entry: Biomechanics of man 2000, ISBN 80-244-0193-2
Institution: Institute of Thermomechanics AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0107260