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Late effect of perinatal hypoxia and pleiotropic effect of statins on acute ischemia-reperfusion myocardial injury
Malý, Jiří ; Pirk, Jan (advisor) ; Kittnar, Otomar (referee) ; Pudil, Radek (referee)
Background: In last decades there were many experimental interventions protecting myocardium against ischemia but aside from early reperfusion none of them was successfully adopted in clinical practice. In our experimental work we try to apply clinical situations into an experimental condition to find out feasible solution how to influence tolerance of myocardium to ischemia. We choose two actual clinical settings: 1. congenital cyanotic heart defects and 2. hypercholesterolemia chronically treated with statins Aim: To examine: 1. the effect of of perinatal hypoxia to the tolerance of the adult myocardium to acute ischaemia/reperfusion injury with regard to sex; 2. the effect of the acute and chronic statin treatment on the tolerance of the adult rat myocardium to ischemia. (...) The effect of perinatal hypoxia on myocardial infarct size in adult males and females was not demonstrated. 2. Acute administration of statin to rats in vivo significantly decreased infarct size expressed as IS/LV, in comparison to infarct size expressed as IS/AR the protective effect of statin administration was suggested, but did not reach statistical significance. Acute administration of statin during reperfusion significantly reduced the contractile dysfunction. However, this protective effect of statins was not present after...
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Tissue and clinical response to prevention of pentasaccharide
Trča, Stanislav ; Krška, Zdeněk (advisor) ; Kittnar, Otomar (referee) ; Kvasnička, Jan (referee)
Administration of coagulation-active substances is one of the options to prevent thromboemboembolic disease (TED), including deep vein thrombosis and systemic response to stress entailed by an injury or a surgical procedure. Lately, a synthetic analogue of the heparin molekule - of its functionally active part - pentasaccharide (PS), has been developed, among others. Potential effects of different pharmacopreventive therapies of the deep vein thrombosis was studied in a group of 146 subjects, who suffered proximal femoral fractures and were operated in the Ist Surgical Clinic,VFN Hospital, during 2001-2006. The patients were randomized into 4 different anticoagulant groups (UFH, LMWH, PS short-term and PS long-term). Thromboembolic symptoms, selected postoperative complications and laboratory findings of selected blood count parameters, coagulation, active phase proteins and adhesion molecules, were monitored. The results indicate existing increased risk of the deep vein thrombosis and a lower rate of the coagulation and fibrinolytic cascade activation, suggesting a higher rate of the hemostatic status stability in the pentasaccharide groups, especially in the groups receiving the long-term pentasaccharide medication (over a month). Therefore, potential pentasaccharide protective effect preventing...
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