National Repository of Grey Literature 11 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Changes in individual isoforms of nitric oxide synthase in experimental hypertension and metabolic syndrome: genetic and molecular-biological aspects
Hojná, Silvie ; Kuneš, Jaroslav (advisor) ; Pelouch, Václav (referee) ; Kittnar, Otomar (referee) ; Cífková, Renata (referee)
Changes in individual isoforms of nitric oxide synthase in experimental hypertension and metabolic syndrome: genetic and molecular-biological aspects Powered by TCPDF (www.tcpdf.org)
Genetic and molecular mechanisms of arterial hypertension in relation to chronic inflammation, oxidative stress, and chronic kidney disease
Krajčoviechová, Alena ; Cífková, Renata (advisor) ; Widimský, Jiří (referee) ; Vaněčková, Ivana (referee)
This thesis provides an appraisal of the structure of clustering of metabolic phenotypes and evaluates the pathophysiological mechanisms underlying the relationship between urinary uric acid and albumin excretion. Two population-based studies were involved. In the first part, we used data obtained in a large representative cross-sectional survey in the Czech Republic (Czech post-MONICA study). We showed that the urinary albumin/creatinine ratio (uACR) was an independent factor for an increase in serum uric acid (SUA) levels in adults without manifest metabolic syndrome (MetS), but with 1-2 MetS component(s). Furthermore, SUA levels increased by the synergistic interaction of uACR with visceral adiposity and blood pressure, which may suggest obesity-related hypertension with altered renal hemodynamics as the primary mechanism. In the second part, we analyzed data captured in a representative population sample of French Canadians (CARTaGENE study) with more detailed urine biochemical analyses available. This study yielded two novel observations. First, we showed that the rs13129697 major T allele, which has been associated with increased SUA levels in our analysis as well as in prior publications, was associated with a paradoxical decrease in uACR. The reason for this discrepant finding is the...
The relationship between lower extremity arterial properties and aortic stiffness and their effect on cardiovascular risk
Wohlfahrt, Peter ; Cífková, Renata (advisor) ; Karetová, Debora (referee) ; Bulvas, Miroslav (referee)
The ratio of systolic blood pressure at the ankle to arm systolic pressure (ankle- brachial index - ABI) is used in the diagnosis of peripheral vascular disease. While its reduced value suggests obstruction of the arterial lumen, an abnormally elevated value is due to incompressibility of lower extremity arteries. While increased stiffness of the aorta, measured as carotid-femoral pulse wave velocity, is able to predict cardiovascular risk, increased pulse wave velocity of the leg arteries has no independent predictive value. Despite that, incompressibility of lower extremity arteries, diagnosed using ABI measurement, is independently associated with increased cardiovascular risk. The aim of our study was to determine the relationship between the characteristics of lower limb arteries and aortic stiffness, and their impact on cardiovascular risk. Our study showed that the results of oscillometric and Doppler ABI measurement methods are not interchangeable, because the oscillometric method systematically overestimates low values and underestimates high ABI values. Therefore, the diagnosis of lower limb arteries incompressibility should be based on the Doppler method of ABI measurement. Furthermore, we showed that age and cardiovascular risk factors have only a small effect on lower extremity arteries, but a...
Genetic and molecular mechanisms of arterial hypertension in relation to chronic inflammation, oxidative stress, and chronic kidney disease
Krajčoviechová, Alena ; Cífková, Renata (advisor) ; Widimský, Jiří (referee) ; Vaněčková, Ivana (referee)
This thesis provides an appraisal of the structure of clustering of metabolic phenotypes and evaluates the pathophysiological mechanisms underlying the relationship between urinary uric acid and albumin excretion. Two population-based studies were involved. In the first part, we used data obtained in a large representative cross-sectional survey in the Czech Republic (Czech post-MONICA study). We showed that the urinary albumin/creatinine ratio (uACR) was an independent factor for an increase in serum uric acid (SUA) levels in adults without manifest metabolic syndrome (MetS), but with 1-2 MetS component(s). Furthermore, SUA levels increased by the synergistic interaction of uACR with visceral adiposity and blood pressure, which may suggest obesity-related hypertension with altered renal hemodynamics as the primary mechanism. In the second part, we analyzed data captured in a representative population sample of French Canadians (CARTaGENE study) with more detailed urine biochemical analyses available. This study yielded two novel observations. First, we showed that the rs13129697 major T allele, which has been associated with increased SUA levels in our analysis as well as in prior publications, was associated with a paradoxical decrease in uACR. The reason for this discrepant finding is the...
The relationship between lower extremity arterial properties and aortic stiffness and their effect on cardiovascular risk
Wohlfahrt, Peter ; Cífková, Renata (advisor) ; Karetová, Debora (referee) ; Bulvas, Miroslav (referee)
The ratio of systolic blood pressure at the ankle to arm systolic pressure (ankle- brachial index - ABI) is used in the diagnosis of peripheral vascular disease. While its reduced value suggests obstruction of the arterial lumen, an abnormally elevated value is due to incompressibility of lower extremity arteries. While increased stiffness of the aorta, measured as carotid-femoral pulse wave velocity, is able to predict cardiovascular risk, increased pulse wave velocity of the leg arteries has no independent predictive value. Despite that, incompressibility of lower extremity arteries, diagnosed using ABI measurement, is independently associated with increased cardiovascular risk. The aim of our study was to determine the relationship between the characteristics of lower limb arteries and aortic stiffness, and their impact on cardiovascular risk. Our study showed that the results of oscillometric and Doppler ABI measurement methods are not interchangeable, because the oscillometric method systematically overestimates low values and underestimates high ABI values. Therefore, the diagnosis of lower limb arteries incompressibility should be based on the Doppler method of ABI measurement. Furthermore, we showed that age and cardiovascular risk factors have only a small effect on lower extremity arteries, but a...
Changes in individual isoforms of nitric oxide synthase in experimental hypertension and metabolic syndrome: genetic and molecular-biological aspects
Hojná, Silvie ; Kuneš, Jaroslav (advisor) ; Pelouch, Václav (referee) ; Kittnar, Otomar (referee) ; Cífková, Renata (referee)
Changes in individual isoforms of nitric oxide synthase in experimental hypertension and metabolic syndrome: genetic and molecular-biological aspects Powered by TCPDF (www.tcpdf.org)

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