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Synthesis and Utilization of Selected Nitrogen Heterocycles
Mikušek, Jiří ; Pour, Milan (advisor) ; Veselý, Jan (referee) ; Bureš, Filip (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Mgr. Jiří Mikušek Supervisor: prof. RNDr. Milan Pour, PhD. Title of Doctoral Thesis: Synthesis and Utilization of Selected Nitrogen Heterocycles The thesis is divided into two parts, both dealing with the synthesis of pyridine and pyrimidine derivatives. The first one is focused on the cyclization of enynes with gold(I) catalysts. Main attention is paid to the synthesis of various acyclic precursors starting from propargylamines, their addition to propiolates and Sonogashira cross-coupling. The mechanism of the cyclization with (TFP)AuCl is then discussed in detail. Prepared dihydropyridines were converted to pyridines or tetrahydropyridines. A precursor of the antidepressant drug paroxetine was prepared. The second part deals with quinazoline alkaloids with pyrimidine moiety and their structural variations towards potential organocatalysts and biologically active compounds. Therein new types of organocatalysts based on the structure of vasicine were prepared and screened on model aldolization and addition reactions. Prepared compounds were tested for bronchodilator activity.
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The synthesis of substituted pyridines employing gold(I) catalyst
Janoušek, Martin ; Špulák, Marcel (advisor) ; Kuneš, Jiří (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Martin Janoušek Supervisor: PharmDr. Marcel Špulák, Ph.D. Title of thesis: The synthesis of substituted pyridines employing gold(I) catalyst This work is focused on the preparation of 3,4-disubstituted pyridine derivatives. MBS- protected propargylamine and MS-protected 1-ethynylcyklohexylamine provide with methyl propiolate to form appropriate 1,5-enyne, which undergoes Sonogashira coupling with various aryl iodides. Substituted enyne is subjected to cyclization yielding appropriate tetrahydropyridine in the presence of catalyst tris(2-furyl)phosphinegold(I) chloride. Derivate substituted by pentamethylen-1,5-diyl didn't cyclize. Deprotection leads to the preparation of substituted pyridines, which could serve as an intermediates in organic synthesis or potentially with biological activity. Keywords: gold catalysis, enyne cyclization, pyridine derivatives
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HPLC method development and validation for analysis of anthocyanins in highbush blueberries
Křížová, Kateřina ; Šatínský, Dalibor (advisor) ; Sklenářová, Hana (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Kateřina Dostálová Supervisor: Doc. RNDr. Dalibor Šatínský, Ph.D. Title of Diploma Thesis: HPLC method development and validation for analysis of anthocyanins in highbush blueberries HPLC method for simultaneous determination of anthocyanins: delphinidin-3-O-galactoside, delphinidin-3-O-glucoside, cyanidin-3-O-galactoside, cyanidin-3-O-glucoside, cyanidin-3-O- arabinoside, peonidin-3-O-glucoside and malvidin-3-O-galactoside in 21 varieties of blueberries ('Spartan', 'Sunrise', 'Toro', 'Bluegold', 'Croatan', 'Northland', 'Duke', 'Gila', 'Jersey', 'Bluecrop', 'Herbert', 'Berkeley', 'Patriot', 'Darrow', 'Bluetta', 'Collins', 'Brigitta', 'November', 'Iranka', 'Bluejay' and 'Rancocas') was developed and optimized in this thesis. Kinetex PFP column, 150 x 4.6 mm (particle size 2.6 µm) was used for the analysis. The detection was performed by DAD detector at 520 nm, column temperature of 50řC using gradient elution with a mobile phase of acetonitrile/ 2 % formic acid at a flow rate of 1.0 ml/min. The total time of the analysis of one sample took 21 minutes. Keywords: HPLC, blueberries, anthocyanins, polyphenols, antioxidants, delphinidin-3-O- galactoside, delphinidin-3-O-glucoside,...
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Contour lines to heightfield conversion
Klimeš, Jonáš ; Pelikán, Josef (advisor) ; Dupej, Ján (referee)
Title: Contour lines to heightfield conversion Author: Jonáš Klimeš Department: Department of Software and Computer Science Education Supervisor: RNDr. Josef Pelikán, Department of Software and Computer Science Education Abstract: The task of this project is to design and test algorithms for semiautomatic contour lines conversion to height field. This work tries to solve following problems: automatic connection of disconnected contour lines, adjacent paths finding, semiautomatic ordering of contour lines with user assistance, creating of terrain height field using Catmull-Rom splines or radial basis functions. A part of this thesis is an experimental application, which implements these algorithms and displays the process of conversion. Program input are in form of contour lines in SVG vector format. Output 3D meshes are in Wavefront OBJ format. Keywords: contour lines, height field, terrain
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Case Study of Physiotherapy Care of Patient with Arthroplasty of the Shoulder Joint
Lerlová, Barbora ; Pavlů, Dagmar (advisor) ; Homolka, Jiří (referee)
Author: Barbora Lerlová Title: Case Study of Physical Treatment of Patient with Arthroplasty of the Shoulder Joint The aim of this bachelor's thesis is to introduce the issue of operations cervicocapital prosthesis shoulder joint and following physiotherapy care. The general part deals with theoretical knowledge to the diagnosis in terms of anatomy, biomechanics and kinesiology of the shoulder girdle, contains information on operational approaches arthroplasthy of the shoulder joint and the possibilities of physiotherapy practice. A special part contains a case report of a patient after implantation arththoplasty of the shoulder joint, which were worked up during special practice in MediCentrum in Prague since 23rd January to 17th February 2012. The patient physiotherapy examination was performed, design and course of therapy. The examination was performed at the first and the last therapy. At the end of the special part is evaluated the effect of applied therapy and physiotherapy techniques. Key words: fracture, shoulder, cervicocapital replacement, physiotherapy
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Automatic Modifications of Context in Text Fields
Dřínek, Vratislav ; Bojar, Ondřej (advisor) ; Horký, Vojtěch (referee)
Title: Automatic Modifications of Context in Text Fields Author: Vratislav Dřínek Department: Institute of formal and applied Linguistics Supervisor: RNDr. Ondřej Bojar Ph.D., Institute of formal and applied Linguistics Abstract: The topic of this bachelor thesis is text editor assistant. The program tries to anticipate user's intentions and propose their quick accomplishion. The aim of this thesis solves is completely new and its function is not available even in advanced text editors. The topic is inspired by the user's interface of the programming enviroment Visual Studio, which sometimes proposes the program code the user is probably going to write. The assistant uses morphological analyses provided by Morphodita to analyse sentences morpologically. Keywords: sentence analysis, Czech dictionary, Morphodita tagger, autocomplete
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Traditional and modern approaches to pricing in nonlife insurance
Vojtěch, Jonáš ; Branda, Martin (advisor) ; Mazurová, Lucie (referee)
Title: Traditional and modern approaches to pricing in nonlife insurance Abstract: This thesis deals with the theory and implementation of generalized linear models in the area of pricing of non-life insurance and subsequent optimalization of rates. Using the generalized linear models it is possible to estimate expected value and variance of compound distribution of total claims made according to insurance policy during definite time period. The next step is to build an optimalization model and describe several methods how to determine rates that lead to optimal distribution of safety margins within insurance policies in particular risk groups. Represented approaches how to calculate insurance premiums are numerically illustrated on simulated data in concluding parts of the thesis.
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Diagnosis of communication disability for people with Parkinson's disease
Růžičková, Hana ; Klenková, Jiřina (advisor) ; Hájková, Vanda (referee) ; Dlouhá, Olga (referee)
TITLE: Diagnosis of communication disability for people with Parkinson s disease AUTHOR: Hana R i ková Mgr. DEPARTMENT: Special education department SUPERVISOR: Ji ina Klenková, Doc. PaedDr., PhD. ABSTRACT: The doctoral thesis deals with diagnosing communication disability for people with Parkinson s disease (PD). PD is a progressive neurodegenerative disorder associated with high occurrence of hypokinetic dysarthria (HD). The theoretical part of the thesis characterizes Parkinson s disease, weak and strong points of logopaedic diagnostics and describes HD. The empirical part of the thesis is based on quantitative research. The aims of our study were to modify test Dysarthric profile 3F to be more sensitive to mild stage of HD, to detect HD symptoms in early untreated PD patiens, to notice HD progression in retest, to objectify results of clinical evaluation by acoustic measurments and to detect subjective perception of patient s own speech. We studied people with PD and neurologically healthy control speakers. We evaluated HD in 50% PD subjects in early untreated stage of PD and in 74% PD speakers in retest. We observe that between the most sensitive diagnostical tasks in clinical evaluation with high correlation with acoustic analysis belong evaluation of hoarse voice in sustained phonation of vowels and...
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Strategic Analysis of an Enterprise
Kurková, Michaela ; Dvořák, Jiří (advisor) ; Ezrová, Hana (referee)
The title of this Diploma Thesis is Strategy Analysis of the Enterprise. Subject of the Thesis is to analyse the current status of Zlichovec Brewery and to propose suitable strategy for further developing the Brewery in future. Method of the external and internal environment analysis is applied in the Thesis. Theoretical/methodical factors defining individual analyses is included in the first part of the thesis whereas practical application of the indentified findings on the respective Brewery is described in the second part. Based on the results debated in the second part thereof, evaluation of the existing strategy is provided and eventual changes in order to improve development of the Enterprise or to modify its strategy respectively are formulated.
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Theatre as a free vision of the world (theatre and jazz)
Valerián, William ; PAVLATA, Michal (advisor) ; TÖPFER, Tomáš (referee)
My thesis is titled Theatre as a free vision of the world (theatre and jazz). I deal with my search for connections between music and acting artistic expression during the study, which began at the conservatory – saxophone department. From acting lessons and later works in the school theatre Disk I choose the moments that helped me to find my own „jazz“ acting approach and „liberation" on the stage and its subsequent use in later professional life.
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