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Civil society and civil participation at municipal level (case study of Prague 5 district)
Bazgerová, Martina ; Müller, Karel (advisor) ; Lisa, Aleš (referee)
In connection with a process of democratization of the Czech Republic the topic of an civil society becomes more and more topical. This study focuses mainly on one of its functions -- civil participation -- and on the case of the Czech Republic it proves Beck's hypothesis that civil society and civil participation mobilize itself in reaction on critical situation, and it tries to find an explanation of this hypothesis. To set criteria for analyzing the given hypothesis, and its subsequent explanation the condition of civil society in the Czech Republic is analyzed with regard to both historical and contemporary influences and public opinions of citizens. Then, the study moves to verifying the main hypothesis on the case of the Prague 5 district. For this purpose analyzing of medial causes and mainly reactions of citizens to it, is used.
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Cleaning Validation Procedures in Manufacturing of Liquid Dosage Forms
Koníková, Veronika ; Doležal, Pavel (advisor) ; Vachek, Josef (referee)
The thesis preamble introduces validations of analytical methods, as an important process during pharmaceutical development and quality control in pharmaceutical manufacturing. Method validation has essential influence on pharmacoeconomics and greatly shortens the time of placing the medicament to the market. The IMS principle greatly shortens analysis time, thus ensuring economic and innovation growth for pharmaceutical companies. Experimental part of this thesis was performed on the device IONSCAN - LS Smiths- Detection, USA in the branch of the Teva company in Opava, which introduces IMS to analytical procedures validation for cleaning validation in pharmaceutical manufacturing. For measuring, the Naphazolini nitras standard was used and the Teflon dry method was applied. During the method development itself, in which I participated, the method usability range was found in the interval of mass concentrations from 0,06 - 0,80 mg / ml. The detection limit at the level of 0.02 ppm and the quantification limit at the level of 0.08 ppm were determined and linearity was verified. In the second part, I validated the analytical method for cleaning process validation. Sampling was performed by means of polyurethane swabs "Large Swab" from a metal plate of surface size 5 x 5 cm2. From this equipment, a...
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Coach Opinions on Present Problems of Coach Job
Vancl, Karel ; Kocourek, Jan (referee) ; Kovář, Karel (advisor)
Autor: Be. Karel Vancl Title of the thesis: Opinion of coaches regarding current issues of trainer's profession Location: Pedagogy, Psychology and Didactics PE and sports Faculty Department Thesis tutor/supervisor: PhDr. Karel Kovaf, Ph.D. Presentation year: 2010 Abstract: Thesis objectives: The objective of the study was to evaluate current profession issues and challenges of sport coaches. The study was focused on motivation, remuneration, trainer's education and competencies across different coach levels. We tried to find-out the influence of degree of education on coaches' opinion on current sport training issues. Part of the study was to collect the satisfaction feedback of participants about training courses organized by FTVS UK (Faculty of Physical Education and Sport of the Charles University in Prague). Methods: Questionnaire-based evaluation was carry-out in 2007-9 during educational courses on FTVS. Overall data from 601 coaches representing 29 sport branches were compiled. The Questionnaire designed by Svoboda (1997) and already used in previous examinations was applied. Results: A major shift rurned-up compared to previous researches regarding coaches' opinion on financial rewards for the trainer's job. It was confirmed that mostly coaches with the university sport science or secondary...
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Civic society in Slovakia. Focus on the local level
Dobrucký, Martin ; Bureš, Jan (advisor) ; Polášek, Martin (referee)
The civic society is one of the basic elements of democracy. It reflects how democracy is incorporated in the society and in its citizens' awareness. It uncovers if/how it is taken and accepted by citizens. The true civil society requires participation and an active attitude from citizens who change themselves from a passive mass into real co-originators of the policies. The presented thesis focuses on the study of a citizen and its role in the democracy of Slovakia. It analyses the behavior of a citizen on the local level, where he/she has the closest contact with the policy. It is the local level where he/she has the greatest chance of participation in the policy making processes.
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Role of the PDZ Domain-Binding Motif of the Oncoprotein E6 in the Pathogenesis of High Risk Papillomaviruses
Faflíková, Tereza ; Španielová, Hana (advisor) ; Plocek, Vítězslav (referee)
The infection by high-risk human papillomaviruses is involved in causing cancers. The extreme carboxy terminus of high-risk α-HPV E6 protein contains a PDZ domain-binding motif. The E6 protein of high-risk HPV binds by PDZ domain-binding motif to cellular proteins containing PDZ domain, which participate in the maintenance of the cell polarity, in the stabilization of cell-cell junctions or in the regulation of cellular signaling pathways, e.g. hDlg (human homologue of Discs large protein), hScrib (human homologue of Drosophila tumor suppressor Scribble). Binding of E6 with cellular proteins prevents the induction of apoptosis and influences the enhancement of growth rate of infected cells, degradation of tight-junctions, regulation of cell polarity and vesicular transport. The interaction between E6 and cellular proteins increases the stability of E6 protein and protects E6 from proteasomal degradation. PDZ domain-binding motif of E6 high-risk HPV contributes to the development of malignant tumors.
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Basic Jumping Skills of Senior School Children
Šátek, Jan ; Vindušková, Jitka (advisor) ; Krátký, Petr (referee)
Basic jumping skills of pupils in older school age This project is about training basic jumping exercises and their influence on performance jumping events (especially long jump, high jump). I've worked with a group of athletes from 11-15 years old . The basis of my research was a creation a large number of picture kinograms of chosen jumping exercise and then their analysis. These kinograms were taken in the interval of one year, in the spring 2005 and spring 2006, by digital camera. I've compared the performance of chosen jumping exercises mainly for a long jump a high jump, their technical component and also each athlete's personal results. I've also measured a physical growth of pupils. I've found out that a regular training of chosen jumping exercises has a great effect on their performance and also on a technical side of jumping event. And when it comes to personal results of chosen athletes,in long jump and high jump, I'm glad to say that they have also increase a lot. My research has shown that better efficiency of older school aged pupils is caused by two main factors: the physical growing up and the level of performance in the event. Keywords: basic jumping exercise, older school age, long jump, high jump
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The Assessment of Pain by a Nurse and the Control of Post-operative Pain
Hanousková, Jana ; Chloubová, Helena (advisor) ; Di Cara, Veronika (referee)
This diploma work is focused on post-surgical pain. It lays out the role of a nurse in pain assessment, factors influencing post-surgical pain and ways of its controlling. It also publishes the results of the research organized in the surgical fields of the Central Military Hospital Prague in January and February 2006. The work is structured into two large parts, theoretical and empirical one. The diploma work underlines the importance of the team cooperation of all those who participate in pain management and in individualized complex nursing care for a patient in the past-surgical time period.
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The molecular mechanism of CSL protein participation in oxidative stress response in Schizosaccharomyces pombe
Daněk, Petr ; Převorovský, Martin (advisor) ; Sipiczki, Matthias (referee)
Redox homeostasis maintenance is important for proper organism and cell function, for while relatively low amount of reactive oxygen (and nitrogen) species contributes to the fine tuning of signal transduction, excessive concentration of ROS (oxidative stress) has demonstrably harmful effects and is tightly connected to many pathological states. Cells therefore evolved broad palette of antioxidant mechanisms that express striking level of conservation among different species. Large, intricate stress response signaling networks have been already described; nonetheless, novel molecules employed in stress-related signaling are still being discovered. Several studies recently suggested transcription factors CSL, proteins essential for regulation of metazoan development as effectors of Notch signaling, are also involved in response to oxidative stress. The fission yeast Schizosaccharomyces pombe, well established model of response to various stresses, comprises two paralogs of CSL proteins - Cbf11 and Cbf12. We have found cells depleted of cbf11 are highly resistant to hydrogen peroxide. This resistance appears to be caused by upregulation of important stress responsive genes including ctt1, gst2, pyp2, and atf1. Cbf11 is therefore negative regulator of these genes, which suppresses their expression...
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Political Aspects of Local Government - Party System of Nýrsko
Hošková, Jana ; Kopřiva, Radek (advisor) ; Lenka, Lenka (referee)
The present dissertation is focused on the development of the party systems on the local level of political decision making with the aim to verify applicability of the party systems theory. The dissertation is divided into two parts - the theoretical bases and the thesis itself. The theoretical part deals with the definitions of the fundamental concepts, such as a political party, a municipality, municipal administration, the municipal election system, and last but not at least it is focused on the party systems and their applicability in practice. The practical part of the dissertation is approached as a case study dealing with the town of Nýrsko. It contains a short characterization of the basic demographic and socio-economic indicator of the municipality. The thesis searches for the main factors having an influence on the party system in the municipality of Nýrsko, it inquires about the political area for the consequent study of the political system, the extent of political participation, the political plurality and the inception of political parties. Then the applicability of the party system theory and the role of political parties in the local political area are researched.
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THE EVALUATION OF LEVEL OF THE QUALITY AND AVAILABILITY OF SOCIAL SERVICES IN THE CENTRAL BOHEMIAN REGION IN 2015
Vavrochová, Jaroslava ; Kotýnková, Magdalena (advisor) ; Barák, Vladimír (referee)
The aim of the diploma thesis is to analyse provided social services and to evaluate their current level of the quality ,availability and structure in the Central Bohemian region. Special attention is devoted to the district of Kladno, which is one of the most populous districts of the region. The topic of social services is not only actual from the point of view of demographic trend of the population ageing, but nowadays it is also necessary to give an essential succour to other disadvantaged groups of the inhabitants. It is possible to say that social services have an influence on the quality of life and the current social system is based on the high level of social services and on the comprehension of specific needs of the individuals. The thesis devotes to the availability and structure of social services, which are provided for individual target groups of the inhabitants in the Central Bohemian region. The thesis concludes that social services are afforded in the desirable structure and mainly in bigger cities. The lower number of social services is given in smaller central and peripheral areas of the region. In the district of Kladno there is given the large number of social services of all sorts. They are available in the high quality. Nevertheless, the offer of social services for pensioners is not sufficient, the main reason is insufficient capacity of the long-stay services.
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