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Investigation cholesterol in terrain, fall results on style of life examinate persons.
DVOŘÁK, Vít
The thesis is focused on the lifestyle of people with elevated cholesterol level. Fundamental terms, which are basic for the topic, are explained. The latest findings stated in professional literature on lifestyle, health, diseases, health promotion and health prevention are presented. The most recent statistical results are mentioned The first section of the thesis is focused on the issue in general, i.e. on lifestyle, the definition of health and its determinants, nutrition and stress. A large section is devoted to determinants of health that significantly affect human health. These are healthcare, genetics, environmental impacts. Therefore, the great importance of our lifestyle, which may be influenced by smoking, stress, physical activity, drug use, alcohol consumption and diet, is demonstrated. A large part of our activities can be positively influenced by ourselves. The determinants and their effects on human body are mentioned. The main focus is put on diseases associated with elevated cholesterol levels, where cardiovascular disease stands first. Another aspect makes a positive side and this is healthy lifestyle. Healthy lifestyle and practices how to positively influence our health are characterized. A specific decalogue, giving certain constrains, is outlined. And also the irreplaceable role of prevention and health promotion, which is one of activities of the public health protection authorities, is mentioned. The projects of the World Health Organization also contribute to the population health promotion. The project Health 21 is also mentioned in this thesis. The objective of this study was to analyze the results of cholesterol tests in the framework of a screening program in the South Bohemian Region carried out over the period of three years. A sub-objective was to determine the lifestyle changes in clients with the decrease in blood cholesterol levels. The main hypothesis is ? there is a rising trend in elevated cholesterol levels in the blood In the practical section the results obtained from the qualitative research focused on the lifestyle of people with elevated cholesterol levels are presented. The issues concerning their lifestyle such as physical activity, stress, smoking, dietary habits, fluid intake and sleep are investigated. The questionnaire survey and the subsequent analysis of the data obtained have shown that these persons have a more responsible approach to their lifestyle. They admit that the results of the tests focused on cholesterol levels positively affect their lifestyle. The majority of respondents positively affect their lifestyle according to theoretical recommendations. Comprehensive investigation has proved that the overall lifestyle is comparable to the general population.
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Assessment of damage in game hunting LCR sp "Vápenice"
JOZA, Jaroslav
The objective of this graduation thesis was to find out the extent of damages caused by wildlife to the forest stands up to 30.6.2009 and agricultural stands during 2009 in the hunting district LČR s.p. (Forests of the Czech Republic) "Vápenice". The damages to forest stands have a large impact on the function and recovery of the forest, while the damages to agricultural stands have negative effects on farmstead. Hence the first part of this thesis is concerning with methods of protection of both the forest, and farm crops to prevent it from being damaged. In this graduation thesis, percentage outcomes of damage of forest and agricultural stands, which were caused by wildlife, are stated. The damage to forest stands in all age groups in the hunting district "Vápenice" reach approximately one half in comparison to damage rate of the whole Czech Republic. The damage to permanent grass stands is higher than the damage to cereals.
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Influence of Polyphenolic Substances with Iron Chelating Activity in Model of Acute Myocardial Infarction and Oxidation Stress Induced by Catecholamines
Zatloukalová, Libuše ; Hrdina, Radomír (advisor) ; Tilšer, Ivan (referee) ; Patočka, Jiří (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate Mgr. Libuše Zatloukalová Supervisor Prof. MUDr. Radomír Hrdina, CSc. Title of Doctoral Thesis Influence of polyphenolic substances with iron chelating activity in model of acute myocardial infarction and oxidation stress induced by catecholamines Background and aim: Ischaemic heart disease (IHD) and particularly its most serious form - acute myocardial infarction (AMI) - represents significant health problem in the developed countries with relatively high mortality. Within multifactorial pathogenesis of AMI, reactive oxygen and nitrogen species (RONS) generated by free iron catalytic effect and increased activity of the sympathetic nervous system accompanied with a release of the catecholamines play a significant role. Large doses of the synthetic katecholamine isoprenaline has been used as a suitable experimental model of AMI. AIM is considered as typical form of ischaemic-reperfusion (I-R) injury. RONS, which are excessively released during the first minutes of reperfusion, play a significant role in the pathogenesis of myocardial I-R injury. Free iron significantly increases the process of RONS generation. Use of iron chelators could have protective influence in I-R injury and...
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Crime in Suburbs: Case Study in the Municipality Sulice
Hrbková, Jana ; Temelová, Jana (advisor) ; Jíchová, Jana (referee)
The aim of this work is to determine the perception of crime and feeling of security people who live in the new development in the village Sulice, which is located in suburb of Prague. In this village happened in the past and even now there is a large extent to the process of suburbanization. During the last twenty one years they have moved in to the family home nearly a thousand new residents. And therefore is an option that this suburban location is an attractive target for the perpetrators of property crime. In the village Sulice structured interviews were conducted with local residents and the mayor and deputy mayor. Based on structured interviews, practical part of the thesis is made. Research aims to determine what type of crime, people in the village Sulice most worried about and why. The work focuses on the security measures taken against the perpetrators. The results showed that almost all of respondents feel safe in the village, although half of all respondents had a negative experience with a local crime. Respondents are most worried about property crime. The most effective security measures are dogs and mainly supervision of family members and neighbours. Keywords: Suburbium, property crime, a feeling of safety, experience with crime, protective security measures
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Role of the PDZ Domain-Binding Motif of the Oncoprotein E6 in the Pathogenesis of High Risk Papillomaviruses
Faflíková, Tereza ; Španielová, Hana (advisor) ; Plocek, Vítězslav (referee)
The infection by high-risk human papillomaviruses is involved in causing cancers. The extreme carboxy terminus of high-risk α-HPV E6 protein contains a PDZ domain-binding motif. The E6 protein of high-risk HPV binds by PDZ domain-binding motif to cellular proteins containing PDZ domain, which participate in the maintenance of the cell polarity, in the stabilization of cell-cell junctions or in the regulation of cellular signaling pathways, e.g. hDlg (human homologue of Discs large protein), hScrib (human homologue of Drosophila tumor suppressor Scribble). Binding of E6 with cellular proteins prevents the induction of apoptosis and influences the enhancement of growth rate of infected cells, degradation of tight-junctions, regulation of cell polarity and vesicular transport. The interaction between E6 and cellular proteins increases the stability of E6 protein and protects E6 from proteasomal degradation. PDZ domain-binding motif of E6 high-risk HPV contributes to the development of malignant tumors.
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Utilization of Radar Echo Extrapolation for Quantitative Precipitation Forecast
Frolík, Petr ; Novák, Petr (advisor) ; Žák, Michal (referee)
Title: Utilization of radar echo extrapolation for quantitative precipitation forecast Author: Petr Frolík Department: Department of Meteorology and Enviroment Protection Supervisor: RNDr. Petr Novák, PhD., ČHMÚ Supervisor's e-mail address: petr_novak@chmi.cz Abstract: At present time weather radar data are essential for national meteorological services. Utilization of this data for quantitative precipitation forecast and severe weather prediction for short period (nowcasting) becomes more and more common. Increasing interest for quantitative precipitation forecasts can be noticed in hydrological applications, where it can give early warning on flash floods and can improve large scale precipitation forecasts. This paper verifies usability of COTREC nowcasting method based on extrapolation of radar echo for quantitative precipitation forecast. Quality of COTREC forecast up to 3 hours was investigated on data from 1.4.2006 to 30.9.2006. Comparison of COTREC method with Aladin NWP model forecasts was also made. Hourly mean precipitation estimates on catchments were chosen for comparison because of verification focused mainly on utilization of the forecasts in hydrological applications. Forecasted precipitation estimates were compared with optimal operationally available precipitation estimate - adjusted radar...
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Ways of protection of property right in valid rule of law
PROKOPOVÁ, Jana
This diploma thesis deals with problems of the property right and its protection. The protection of property is a law of eminent importance, enjoying considerable public interest, particularly because it is one of the major factors determining the level of individual´s freedom. Legal consciousness among people from general public in the area of the property right was greatly increased after the year 1989. This is demonstrated by the low number of currently solved offences in the administrative procedure. In the civil section of the justice most cases can be traced back to the period of socialism. It is very important to constantly lead an informative and preventive campaign, because for a large number of people the concepts of property rights and its protection pose still a big unknown. In the recent time, bills of new civil and criminal code are being prepared. These standards will have a profound influence on the definite interpretation of property right and reinforcement of its protection. With regard to protection of the property in Austria and Germany, we can say that the level of protection of the property in these countries is comparable to the one in Czech Republic.
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Monitoring the personnel radiation load in percutaneous interventions
SKÁCELOVÁ, Lada
The discovery of ionising radiation at the turn of the nineteenth and twentieth centuries was a landmark for medicine: the methods based on the principle and effects of ionising radiation are used even in the present medicine to a considerable extent. As early as in the very beginnings, adverse affects of ionising radiation were observed, and from this early period the first references to the need of radiation protection date. The fields of medicine dealing with the application of ionising radiation, whether in the diagnosis or in the therapy of diseases, went through an extensive development in their over hundred-year history. It was in the technical sphere in particular where the most important progress was accomplished, thanks to the ever more advanced instrumentation put on the market, meeting the strict criteria of radiation protection. On the one hand, a large group of diagnostic and therapeutic procedures was replaced by new methods (based on ultrasound and magnetic resonance) that are not based on ionising radiation, and thus the patient or the attending personnel are not exposed to the harmful effects of the radiation. On the other hand, the interventional radiology has attained an unprecedented expansion. With the development of new interventional methods and procedures, the number and duration of interventions has been growing. The radiation load to which the intervening personnel are exposed has thus been rising despite the state-of-the-art instrumentation. The theoretical part of the dissertation describes the origin and types of the ionising radiation, its properties and interactions with the environment; a proportional part has been devoted to the biological effects of the radiation. The prime attention has been concentrated on radiation protection, its objectives, principles and methods of radiation protection. An overview of the current legislation and list of requirements on the radiation monitoring has been elaborated. In the chapter on personal dosimetry, the fundamental relations and quantities used in the radiation dosimetry have been described, as well as the types of personal dosimeters and protective equipment. In the practical part, the radiation load of the personnel attending percutaneous interventions in the department of interventional radiology of the Clinic of Radiology of the Teaching Hospital Olomouc was measured. Personal electronic radiation dosimeters Rados, type RAD 60S, were used. All the data obtained were processed using statistical methods, and, on the basis of the results thus obtained, the effectiveness of protection was determined, and the importance of the observation of the principles of radiation hygiene was evaluated. The presumed use of the results of this work in practice is in the optimisation of procedures and measures leading to the maximum possible reduction of the radiation load in percutaneous interventions, and to the education and guidance of personnel towards consequential compliance with all principles of the radiation hygiene.
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