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Reconstructive operations in spine region with bio-ceramic materials use
Lukáš, Richard ; Karpaš, Karel (advisor) ; Štulík, Jan (referee) ; Chaloupka, Richard (referee) ; Rudinský, Bruno (referee)
1. SUMMARY Introduction: During the period of the last 25 years remarkable changes occurred in the treatment of traumas of thoracolumbar spine. The surgical treatment was extended in cases where instability and impairment of its physiological shape are expected. This development is based on the progress in imaging technologies, more detailed understanding of spine biomechanics and a pathophysiology of its impairment. The situation was also influenced by the progression in surgical instruments and implants and also in the technology of bone substitutes. Aim of the study: The aim of the study is to analyze the long term morphological and clinical results after the surgical treatment of thoracolumbar fractures, in which the bioactive glass-ceramics in the form of granules was used as a bone substitute. Material and method: A series of 140 patients treated surgically for unstable thoracolumbar fracture (LSC points 4 - 6) during the period from 1997 to 2003 was studied. The average age of patients was 44 years (14 - 78). The patient collection consists of 83 males in the average age of 43,7 years (14-73) and 57 females in the average age of 44.9 years (15-78). The minimum follow-up was 24 months, the average follow-up period was 29 months. Patient series includes a group of 91 cases, in which the implant was...
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Dysfunction of Endothelium in Relationship to Experimentally Induced
Černý, Dalibor ; Nachtigal, Petr (advisor) ; Štaud, František (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Rigorous Thesis - Abstract Name: Mgr. Dalibor Černý Year: 2007 Dysfunction of Endothelium in Relationship to Experimentally Induced Anthracycline Drugs' Toxicity Endothelial dysfunction is defined as functional lesion of endothelium, characterized by increased permeability of vessel wall, by imbalance among vasoactive, coagulative and proliferation influencing active substances, in result leading to increased expression of cell adhesion molecules VCAM-1 and ICAM-1, which are considered as standard morphological markers of its progress. Adhesion molecules VCAM-1 and ICAM-1 play an important role in building-up of inflammatory reaction and take part in various pathological stages. They are expressed by endothelial cells, by scavenger cells, macrophages and smooth muscle cells. The aim of this rigorous thesis was to examine whether long-lasting daunorubicin administration leads except of significant changes in heart also to the progress of endothelial dysfunction. Imunohistochemical methods were used to detect the expression of these adhesion molecules. Then, the selected heart parameters like LVEF (left ventriculum eject fraction), FS (fractional shortening) and dP/dtmax index, that means peak...
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The Instruction and Education of a Person with a Serious Physical Disability in Adolescence
Švácha, Petr ; Titzl, Boris (advisor) ; Hájková, Vanda (referee)
In My thesis called "Pedagogy and education of adolescent with major handicap" I would like to deal with the determination and comparison of aim in life, values, orientation and perspective of adolescents with progressive muscular Dystrophy. I presume that these adolescents have deficiencies of living the aim of their life and therefore low life satisfaction. To elaborate my dissertation I will use the qualitative research, to be specific - the structure interview method, Schedule for The Evaluation of Individual Quality of Life - SEIQoL and LOGO-TEST of Elizabeth S. Lucas. The outcome will be the research report. I suppose that outcomes of my dissertation will be useful not only for me, but also for the future special pedagogy graduates. These could continue with their research and in that way assist to develop the information sources for educators in practice. I select this theme as I have been working for twelve years as educator in Jedlička Institute and Schools (www.jus.cz) with the handicapped adolescents. Since 1994 - 1997 I was the basic educator. After three years I started the substitute army service which I passed at the Health department as ambulance attendant. After my "army service" I returned to the education sector where I became, after some time, the tutor team leader and now I have been...
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Support of bachelor and master thesis couching
Winkler, Jakub ; Pavlíček, Luboš (advisor) ; Bartoš, Jan (referee)
Today, procedure of creating bachelor and master thesis suffers from many problems. Amongst them the main issue would consist of absence of central storage ability connected to creating and couching the thesis. In practice that would mean information about records from consultation, comments to thesis etc. are to be lost and neither student, nor his thesis couch can take a look to the history of thesis progress. Furthermore, there is a lack of date registration for consultations and deadlines of handing out thesis. As a consequence, both efficiency and quality of final thesis are decreased by such poor management. As a solution, support of whole thesis procedure with software tool is suggested. There are many options of such software solutions, however only one is the most suitable and that is exactly what this thesis is trying to find. Thesis formulates requirements for such software application, after the analysis of current situation and identification of core issues. Application should bring improvement of the situation and at the same time should be users, operational and financially acceptable. From wide spectrum of available solutions, only those which had fulfilled basic conditions were chosen. Basic conditions such as: users interface in Czech language, saving documents availability and large capacity of users accounts. Final group of potential solutions was put through detail analysis for support utility for thesis couching. This analysis finally shows the most suitable solution. This bachelor thesis brings analysis of utility for commonly available web application or hosted applications for bachelor and diploma thesis couching. The implementation could be done quickly without further problems, thanks to the undemanding IT and financial requirements of software application. After finding the most suitable solution, this thesis shows how large scale of efficiency Microsoft SharePoint Services 3.0 brings. Furthermore, at the end of this thesis, many more options for using this application are shown.
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Longitudinal Monitoring of Sports Efficiency in Menś 110 m Hurdles Running in the Top World Competitions
Řehák, Martin ; Kaplan, Aleš (advisor) ; Korbel, Vladimír (referee)
Name: Longitudinal monitoring of sports efficiency in men·s llOm hurdles running on the top world competitions Project goal: The major goal ofthis essay was to compare the results of finalists in men's 110 m hurdles running on World Championship in Athletics during years 1983 - 2005. The results of finalists were monitored from heat to final and were specialized in the time in running, in the position, in the speed of competitors and in their reaction times. The comparison of anthropometric characteristic was next part ofthis work. Methodology: The methodology of the diploma thesis consists mainly of monitoring of selected finalists in men's llO m hurdles running from every World Championship (it means 8 fastest competitors).We followed by these competitors the performance in all progressive running: in heat, quarter-final (in years 1995, 1997, 1999), semi-final and final. We compared datas about times, positions, speed of running, time reaction and anthropometric characterestics of finalists. All these parametres were compared to their counterparts. Results: The total average age of all man finalists, who started in World Championships in years 1983 - 2005, is 26,27 years. The total average body weight of all man finalists in our monitoring period is 78,91 kg. The total average body height of...
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Project Planning and Time Tracking
Kučera, Tomáš ; Zavoral, Filip (referee) ; Zlomek, Josef (advisor)
Software development is much easier with a correct project plan. In our work we study design and implementation of the web system for creating project plans. Users of the system make records about their work and they enter development progress of the tasks in the projects. Emphasis is placed on clearly organized project tree structure with the information about project progress and current costs. The system is programmed in the PHP scripting language. Data are stored in the MySQL database.
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Apoptosis Signating Pathways and Biological Effects of TGFB
Šimáková, Olga ; Fuchs, Ota (advisor) ; Brdička, Radim (referee) ; Holada, Karel (referee)
Apoptosis is necessary for maintaing the integrity of all alive multicellular organisms and therefore needs to be precisely regulated. Very important regulators of apoptosis are pleiotropic cytokines from TFGβ superfamily (e.g. TGFβ, BMP, aktivins), whose signals are transduced by SMAD proteins. Patients with secondary myelodysplasias and acute myeloid leukemias (MDS/AML) frequently exhibit interstitial deletions of the chromosome-5q resulting in hemizygous loss of the transcription transactivator SMAD5. SMAD5 is a member of the signal transducer family conveying the pleiotropic TGFβ/BMP cytokine signals with roles in development, cell growth control, and tumor progression. Consistent Smad5 gene expression in these cell types and the gradual increase in its mRNA and protein levels in a model of induced erythroid differentiation of murine erythroleukemia (MEL) cells suggest a role of the gene in hematopoiesis. We show that bone morphogenetic protein 4 (BMP4) directs Smad5 activation in human hematopoietic cells, as monitored at the levels of protein phosphorylation, nuclear translocation, and specific transcription response. In vitro induction of normal human CD34+ cells by BMP4 results in significantly increased proliferation of erythroid progenitors (BFU-E) and formation of glycophorin- A+ cells, whereas...
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Algebraic Error in Matrix Computations in the Context of Numerical Solution of Partial Differential Equations
Papež, Jan ; Strakoš, Zdeněk (advisor) ; Ramage, Alison (referee) ; Vejchodský, Tomáš (referee)
Title: Algebraic Error in Matrix Computations in the Context of Numerical Solution of Partial Differential Equations Author: Jan Papež Department: Department of Numerical Mathematics Supervisor: prof. Ing. Zdeněk Strakoš, DrSc., Department of Numerical Mathe- matics Abstract: Solution of algebraic problems is an inseparable and usually the most time-consuming part of numerical solution of PDEs. Algebraic computations are, in general, not exact, and in many cases it is even principally desirable not to perform them to a high accuracy. This has consequences that have to be taken into account in numerical analysis. This thesis investigates in this line some closely related issues. It focuses, in particular, on spatial distribution of the errors of different origin across the solution domain, backward error interpretation of the algebraic error in the context of function approximations, incorporation of algebraic errors to a posteriori error analysis, influence of algebraic errors to adaptivity, and construction of stopping criteria for (preconditioned) iterative algebraic solvers. Progress in these issues requires, in our opinion, understanding the interconnections between the phases of the overall solution process, such as discretization and algebraic computations. Keywords: Numerical solution of partial...
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Alternative methods in teaching Czech as a foreign language
Kočová, Kateřina ; Hrdlička, Milan (advisor) ; Valková, Jarmila (referee)
1 Abstract This diploma introduces three alternative methods taught in the study of foreign languages - a method of suggestopedy, Nepustil's method and the Act and Speak method. The purpose of this work is to approach the methods from a historical and methodological perspective. The main focus is aimed at inspections of alternative schools, supplied with student's questionnaires and the visual material from classes. The theoretical part discusses methods from a historical perspective, the progress and presentation of grammar and learning material. Furthermore introducing the basic concept and features of alternative methods with the posibility of applying them during the teaching of Czech language for foreigners. The practical part introduces research made up of inspections at alternative schools along with interviews with founders and successors of these methods. As analysis of the questionnaires that explore the opinions and awareness of teachers about the effectivity and usefulness of untraditional methods in teaching is also a part of it. Practical inspections and conclusions based on the results of questionnaires showed the Act and Speak method to be the most beneficial method. The practical part concludes by presenting other activities for teaching Czech for foreigners that are based on those...
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název v anglickém jazyce není uveden
Ulmanová, Olga ; Růžička, Evžen (advisor) ; Bojar, Martin (referee) ; Stančák, Andrej (referee)
Essential tremor (ET) is probably the most common movement disorder with prevalence quoted as ranging in various populations from 0,41 to 3,92% (Louis et al 1998). Despite often given the prefix "benign", many patients are seriously physically, socially or psychologically handicapped. There are sporadic and familial forms with autosomal dominant inheritance with high penetrance. The percentage of patients with a positive family history ranges from 17 to 100%. Etiology and pathogenesis of ET are unknown. Electrophysiological studies have shown the central source of tremorogenic oscillation, the cerebellum and inferior olive are implicated by positron emission tomography studies. Autopsy studies reveal no gross or microscopic abnormalities (Deuschl and Elble 2000). Essential tremor had been for a long time one of the diseases that were not at a primary focus of neurological research (Deuschl and Koller 2000). Now, with the rapid progress of genetic research, the first genes related to ET have been identified (Gulcher et al 1997, Higgins et al 1997). ET is probably not a single disease; several genetic abnormalities appear to exist (Illarioshkin et al 2000, Abbruzzese et al 2001, Kovach et al 2001). High-quality epidemiological studies are needed for the search for genetic abnormalities (Elble 2000). The...
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