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Performance Management
Uvízlová, Drahomíra ; Stříteský, Marek (advisor) ; Růžičková, Jana (referee)
The Master's thesis "Performance management" is focused on performance of employees in health care system. The main incentive for a writing this Master's thesis was a growing dissatisfaction of employees. Analysis of the thesis is focused on performance management system, which is largely difficult to determinate in health care. For the analysis results to be relevant, it is supplemented with a survey among employees which has confirmed that the system has its flaws, especially in mutual communication between managers and their subordinates. One of the strengths of the system can be the fact that the company is trying to overcome the rigid human resources management system, which still dominates in the contemporary health sector.
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Comparison of sequence variations in genes of biotransfromation enzymes in some carcinoma
Turková, Lucie ; Tavandzis, Spiros (referee) ; Bóday, Arpád (advisor)
Xenobiotic biotransformation process and its capacity is crucial for xenobiotic chemicals elimination that may cause damage toward cell structures. The effectiveness of the enzymes included in this process depends on the gene variants that encodes them. The aim of this work was to compare certain polymorphisms of selected genes between cases and control groups. Studied polymorphisms were null genotypes of the glutathione S-transferase gene M1 and T1 and the insertion of TA dinucleotide in the promotor region of UDP-glucuronosyl transferase 1A1. The number of cases group was six included patients with colorectal, lung, prostate, breast, pancreatic and head and neck cancer. Total number of analysed individuals was 1 118 for cancer cases and 470 for healthy controls. The control group was divided into two groups, the first one was called general and the second one was called special included healthy individuals with no cancer history in their closest family members. Gilbert syndrome (GS) is caused by homozygous insertion of the TA dinucleotide in the TATA box of the gene UGT1A1 and it causes elevated bilirubin levels. Bilirubin is a potent antioxidant in human body, so the aim was to attest its protective effect toward cancer. We expected lower frequency of GS as a protective factor in the cases groups compared with controls. This hypothesis was confirmed in the breast cancer group (GS frequency 10,0 %) and pancreatic cancer group (GS frequency 11,1 %). In the general and special control groups the frequency of GS was 16,0 % and 15,4 % respectively. Although the other case groups show lower frequency of GS, the results weren´t statistically significant. Null GSTM1 genotype was observed with 50,4 % frequency in the general control groups and with 55,3 % frequency in the special control group. Neither the one of the cases groups hasn´t showed significantly lower percentage of null genotype. Despite expectation we observed statistically significant lower frequency of null genotype in the group of lung and pancreatic cancer group (37,4 % and 39,3 % respectively). According to this study, we can say that the lack of glutathione S-transferase M1 activity is not a risk factor for cancer development. Null genotype of GSTT1 wasn´t identified in both control groups at all. In case groups of breast and prostate cancer, there was only one individual carrying the null GSTT1 genotype. Statistically significant higher frequency of this polymorphism was observed in patients with colorectal cancer (9,7 %), lung cancer (17,2 %), pancreatic cancer (3,0 %) and head and neck cancer (15,9 %). In these groups the lack of glutathion S-transferase T1 activity might be considered as risk factor for cancer development. Nevertheless, for further verification it needs to take more investigation in this field, especially enlarge the number of patient in the case groups of head and neck, lung and pancreatic cancer.
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Walloon-Flemish aspect in the national conflict in the Belgian Kingdom
Policar, Martin ; Buben, Radek (advisor) ; Novotný, Oto (referee)
The text is a case study which deals with the theoretical and historical aspects in the dominant conflict in the Belgian kingdom which is the > linguistic cleavage between the Walloons and Flemish. The first part refers to the evolution and development of the Belgian state from the 1830, explicitely after the Second World War till nowadays. The changes of the social strucure such as "verzuilling" and formation of new political parties took place on the background of the linguistic conflicts, which lead into the transition to the so- called Belgian semi-federation. Political parties split into Flemish and Walloon wings and consequently stood in the elections separately. Gradually there was coming up to a decentralisation of power and transfer of power from center towards region. In the 70's and 80's the beginning of the state reforms took place leading towards the fédéralisation of Belgium. Independent executives and councils were set for the regions of Flanders, Walloonia and Brussels as well as for the Flemish, Walloon and German communities. The three-phased state reform was finished in 1992 with the so- called Accord de la St Michel on the full fédéralisation of the state. In the second part of the paper follows the analysis of the theory of consociational democracy by dutch political scientist Arend...
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Historical process of individualization and narcissism as its contemporary manifestation
Bartoš, František ; Šubrt, Jiří (referee) ; Buriánek, Jiří (advisor)
Tato diplomová práce si klade především dva základní cíle: (a) zjistit ruptury v historicko-společenském vývoji, které umožnily vznik a rozvoj individualismu a současně popsat podobu tohoto jevu v daných obdobích (započatých a ukončených jednotlivými zlomy): jeho masovost a souvislosti ve vztahu k fungování a uspořádání celé společnosti, (b) zjištění měřitelnosti narcismu. 2 1.4 Popis struktury diplomové práce, zvoleného metodologického rámce a metod Ad a K určení vzniku a vývoje procesu individualizace v západní Evropě (především v Itálii, Anglii a Francii) poslouží studium relevantní literatury, a to jednak sociologické, ale především historické. Informace týkající se soudobé podoby zkoumaného jevu budou vycházet ze sociologických studií, existujících výzkumů a z autorovi vlastní reflexe dnešní společnosti. Celá tato část práce tak bude mít podobu čistě teoretického výzkumu. Ad b Druhá část diplomové práce bude naopak plně empirická, tvořená dvěma kvantitativními, deduktivní výzkumy. Chronologicky první výzkum bude věnován konstrukci škály narcismu a zjištění její obsahové validity na 151 respondentech. Druhý, již reprezentativní výzkum, podrobí získanou škálu zevrubnější kvantitativní analýze na reprezentativním vzorku čítajícím 1081 respondentů.
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Study of genetic factors modifying the risk of onset and progression of colorectal and pancreatic cancer
Mohelníková Duchoňová, Beatrice ; Souček, Pavel (advisor) ; Skálová, Lenka (referee) ; Macek, Milan (referee)
Introduction: The aim of this study was to evaluate the role of genetic and lifestyle factors in the risk of onset and progression of colorectal and pancreatic cancer. The first part deals with the etiological factors and the importance of polymorphisms in biotransformation enzymes and genetic alterations in the gene CHEK2 in the origin of these malignancies. In the second part, the ABC transporter genes were analyzed as potential prognostic and predictive markers of a treatment's outcome. Materials and methods: The polymorphisms and other genetic alterations were detected using real-time PCR, allelespecific PCR and PCR-RFLP methods in DNA which was extracted from the blood of patients. The frequency of polymorphisms was evaluated and their importance was assessed with regard to the available epidemiological data. Gene expressions were determined by qPCR in paired samples of tumor tissue and adjacent non-tumorous parenchyma. Results: A majority of the observed polymorphisms failed to show a relationship between their presence and the risk of any of these malignancies. CYP2A13 variant allele*7 coding inactive enzyme was found in 7 of 265 controls and in none of 235 pancreatic carcinoma patients. In contrast, GSTP1-codon 105 Val variant allele and GSTT1-null genotype were associated with an elevated...
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Changes in land cover in the summit part of the Mt. Oblík (České Středohoří Mts.)
Kuna, Petr ; Demková, Katarína (referee) ; Treml, Václav (advisor)
Oblík, with his height 509.25 meters above sea level, is the dominant feature of the southwestern part of the České středohoří Mts. which is often referred to as Lounské středohoří Mts.. Geological environment and characteristic climatic conditions prevailing during the last Quaternary glaciation here prompted the creation of natural forest-free areas that are in form of isolated fragments of land preserved to this day. Oblík is one of the most important steppe sites in our area. Ever since the arrival of Neolithic man, the whole region Lounské středohoří Mts. influenced by human intervention. It can be assumed that the influence of grazing helped preserve important sites for steppe at Oblík. From preserved material can be observed the existence of forest on the northern slope. Currently, they are dominated by oak forests with trees such as oak winter (Quercus petraea) and oak (Quercus robur) with an admixture of hornbeam (Carpinus betulus). Contrast, the southern slopes covered many steppe species such as pheasant spring (Adonanthe vernalis), steppe sedge (Carex scales) or a total of five kinds of Stipa (Stipa sp.) and others. On Oblík there are several rare and endangered species that are of interest to the special protection of this National Nature Reserve. At present, the slopes with steppe...
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Cytogenetic methods in genotoxicology
Bártů, Linda ; Langová, Martina (referee) ; Daňková, Pavlína (advisor)
We are constantly exposed to a variety of factors which may be a cause of DNA mutations. The influence of mutagens of physical, chemical and biological origin is studied by genotoxicology. Ionic radiation is among the most common physical mutagens, benzene, vinylchloride or some drugs represent the chemical mutagens, while some viruses and may act as biological mutagens. The repair mechanisms of double strand breaks can be divided into those that require HRR-homologous sequences and those that may use of microhomologies consisting of a short DNA sequence (NHEJ). Both mechanisms can lead to aberrations of chromosomes, if they are not precise. Acquired chromosomal aberrations include translocation, common in cancer cells; deletion; or the production of acentric fragments, dicentrics and rings. Chromatid aberrations includes chromatid breaks and chromatide exchanges. There are various methods for detecting/examining such mutations and these can be categorised according to the phases of the cell cycle. The basic method is clasic Giemsa stain which reveals the most of aberrations except translocations and inversions and numeric abnormalities in metaphasic cells. Another way of testing mutagenicity is determining the rate of sister chromatide exchange; or the so called micronucleus test used to measure...
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The development of the church of saint Jacob Major in the city district of Stodůlky during the years 1985 - 2005
Černý, Štěpán ; Opatrný, Aleš (advisor) ; Eliáš, Vojtěch (referee)
ANOTATION: This bachelor's work describes the development ofthe parish at the church ofSaint Jacob Major in the city district Stodulky during the years 1985 - 2005. At the same time it tries to prove that the general situation in the parish ofSaint Jacob is improving in the sphere of parochial pastorate. The number of received sacraments including Eucharist increases both in the original church and in the new community centre. The influence ofthe parish on the community ofbelievers (Christians) and as well on the neighbouring population is relatively important considering the period andlocality ofthe parish.
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Selected legal aspects of human resources management
Řeháková, Zuzana ; Štefko, Martin (advisor) ; Peřina, Pavel (referee)
SUMMARY: Legal aspects of human resources management At the beginning of the 21st century as much as in the past, the greater part of the population obtains the means for their living through participation in the labour market. Remuneration is not their only motive: people attempt to satisfy other needs such as pursuit of self-fulfilment, establishment of social contacts and overall development of individual personality. Work thus has significant impact on the evolution of society in general. On the level of a business entity, the available human resources, when efficiently organised and managed, can strongly affect the productivity and competitiveness of the venture. To attach sufficient weight to the importance of human resources is a precondition for a successful business. The author of this thesis graduated in Andragogy and Personnel Management and has several years of work experience in the field of personnel management. Because of this, her approach to the subject matter is one of a human resource manager who at the same time advances the interests of the employer and strives to respect and promote the legitimate needs of the employees. This ambivalent position embodies the inherent conflict of labour law - without some level of protection of the employee, as the usually weaker contractual party,...
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Economic Development of Slovakia, 1993-2006
Vavrek, Martin ; Váňa, Daniel (advisor) ; Dufek, Pavel (referee)
Táto práca sa zaoberá analýzou hospodárskeho vývoja Slovenska v období rokov 1993 ? 2006. Snahou je charakterizovať a analyzovať jednotlivé etapy vývoja slovenského hospodárstva v závislosti na politickej moci od vzniku samostatného štátu až po jeho súčasnosť. Práve toto vzájomné prepojenie politiky a ekonomiky veľmi výrazne ovplyvnilo ďalší vývoj a smerovanie krajiny a preto cieľom práce nie charakterizovať vývoj čisto len z hľadiska ekonomického, ale skôr z hľadiska politicko-ekonomického. Zachycuje podrobný chronologický vývoj od rozpadu federácie, cez vznik samostatného štátu a 90.roky, až do súčasnosti. Mapuje jednotlivé vlády a ich vývoj v oblasti tvorby hospodárskej politiky, poukazuje na špecifiká a podmienky jednotlivých období. Práca sa nesnaží poskytovať odborné rady v oblasti hospodárskej politiky a analyzovať účinky prípadných alternatívnych opatrení, ale naopak snaží sa objasniť pravidlá a obmedzenia, v ktorých politickí činitelia jednajú.
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