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Stem cell transplantatiion: The view of intensive care nurse and the patient
Pialová, Miroslava ; Kouba, Michal (referee) ; Pohlreich, David (advisor)
In nowadays, transplantation of haemopoietic stem cell is a healing method, which is used to treat a growing number of patients not only with haematological illnesses and offers them a big chance for a complete recovery. This study tries to zoom in on a nurse's daily job, taking care about the patients after the transplantation. The focus is also on the patient alone, the feelings he or she goes through, perceiving and coming to terms with the illness and the transplantation itself. In order to obtain relevant data we needed to find out the patient's needs, ideas, know-how and satisfaction with the cure by using methods of qualitative examination such as partially structured discussions, observations and their analysis. At the beginning of the study we summarize basic information about the broad issue of stem cell transplantation and delivering a nursing care. Practical part consists of clinical studies. We interpret how the patients undergoing the stem cell transplantation face the reality of their sickness and we shows collected data in a description form. The heamopoietic stem cell transplantation is one of those occasions in life of the sick that puts an enormous pressure on their adaptability. The huge role in it plays also family and members of a medical team. We concluded our study by proposing...
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Formation of the cult of personality (on the example of Czechoslovakia 1945-1957)
Huml, Petr ; Klusáková, Luďa (advisor) ; Pullmann, Michal (referee)
This Bachelor-Thesis focuses on the analysis of the genesis of personality cult on the example of Czechoslovakia in 1945 - 1957, including the reference to, so called, "First Republic". On the grounds of the contents analysis of rich sources, mainly drawn from archives, there is shown how the personality cult was established. It also shows its original signs and its meaning for a state or a regime. The analysis is suported by a large number of citations from primary sources which allows an immediate understanding of the studied phenomenon. The large number of comparison of periodical press and tables based on simple statistics concerning a question of renaming and naming after leading statesmen. The autor supports his argumentation by examples drawing on comparison with similar cases of personality cults, that appeared in different states, where they played not small role in the life of society. In the last chapter is a summary of the analysis and the results of the research carried by the author. The conclusion also offers certain description of the field of research, and a proposal of definition of the personality cult.
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Iron-chelating properties of selected novel chelators from 4-acyl-5-pyrazolone group II
Břečková, Anna ; Mladěnka, Přemysl (advisor) ; Hašková, Pavlína (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Anna Břečková Supervisor: Přemysl Mladěnka, Ph.D. Title of Thesis: Iron-chelating properties of selected novel chelators from 4-acyl-5-pyrazolone group II Iron deficiency and iron overload play important roles in the pathophysiology of certain human diseases. Administration of iron chelators is a suitable therapy in iron overload conditions, especially in cases of hematological diseases treated with blood transfusions. Iron- chelating therapy appears as well as a promising tool for other diseases (acute myocardial infarction, tumor, etc.). Several factors should be considered according to expected indications: 1) oral efficiency, 2) activity in acidic environment, 3) ability to reduce ferric ions to ferrous ions (risk of pro-oxidation). The aim of this thesis was to verify the iron-chelating properties of selected novel chelators from 4-acyl-5-pyrazolone group by use of UV-VIS spectrophotometric methods. From this group, p-terc.butyl- and p-nitroderivatives of the basic structure and the derivatives marked as H2Q3Q and H2QPy, which are double molecules of the basic structure, were chosen. All of the tested substances had some potential to chelate ferrous ions and were also devoid of...
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Oskar Wiener and his creation for children
Adeltová, Helena ; Tvrdík, Milan (advisor) ; Hadwiger, Julia Nina Vanessa (referee)
The subject of this thesis is the German writer and Prague citizen Oskar Wiener, one of the city's lesser known authors from the turn of the 20th century. Special attention is paid to the author's writing for children, works that play a significant role is his overall creative output. The first chapter formulates the subject matter and establishes the goals of the thesis. The second chapter takes a look at the life of Oskar Wiener through the use of archive material, the recollections of friends and autobiographical elements in Wiener's work. The third chapter discusses German literature in Prague at the turn of the 20th century, including the historical background and a presentation of the literary groups of this period, especially the Jung Prag group and its literary tendencies. The fourth chapter is devoted to the Prague neo-romantics, a group to which Oskar Wiener belonged. The fifth chapter provides a brief overview of Wiener's overall work, with an emphasis on his activities as collector and agent. The sixth and seventh chapters then take a closer look at Wiener's writing for children: chapter six introduces his specific works and chapter seven places them in the general context of modern pedagogy. The final chapter summarises the results and insights of the thesis. Keywords Oskar Wiener,...
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The theme of the homosexuality in the modern Arabic prose
Jeníková, Jitka ; Kučera, Petr (referee) ; Ondráš, František (advisor)
This thesis deals with the theme of the homosexuality in the modem Arabic prose, that is to say with the books written in the Arabic cultural environment since the beginning of the twentieth century. The aim of this thesis was to provide a so1id view of the way the homosexuality is presented in the Arabic literature, because the interpretation of different sexual orientation is in the world Arabic studies, let alone in the Czech Arabic studies, really rare. This thesis is divided into two major parts. The first one offers a brief abstract of the historical development of the view on the homosexuality in the Arab world, both from the religious and cultural social point of view. We've tried to show the roots from which grew up the attitude of the reIigious and legal authorities, the way IsIam deals with the homosexuality and the contradictions between the approaches of the society and the religion towards the homosexuality. In the second part we've analyzed eight narrative units written by authors coming from the different regions of the Arab world or of Arabic descent. The authors of those books are both men and women and aH of them deal with the issue of the homosexuality in their works. The primary objective here is to create a holistic view of the way in which a different sexual orientation is treated in...
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Labour Productivity in the Czech Republic
Rousová, Sabina ; Dočkal, Dalibor (advisor) ; Urban, Luděk (referee)
This thesis deals with labor productivity and factors affecting it. Such as technological progress, education and development. Examines how various factors improve productivity and how PA affects other sectors. Furthermore, the focus on comparisons of labor productivity in the Czech Republic and European Union countries - and it seeks to draw conclusions. The work space is defined for comparison between the Czech Republic and the founding States of the European Union and then with all the countries of the European Union. Analyzes the current state of labor productivity in the CR and its impact on the competitiveness of Czech enterprises. Their ability to survive in the global market. At the same time predicts the possible future development of PP and the impact on public finances in the context of accentuated the need for reform. The aim of this work is, among others, are familiar with concepts related to the PP and the PP itself. And on the basis of these data to understand the diversity of PP in different countries and the resulting wage differences.
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Therapeutic applications of monoclonal antibodies.
Sekerová, Lenka ; Navrátilová, Lucie (referee) ; Jílek, Petr (advisor)
Therapeutic applications of monoclonal antibodies (in oncologic indications) Background Monoclonal antibodies (Mab) are one of the possible means of treating oncological diseases. This thesis aims to summarize basic information about them and provide an overview of all antitumour monoclonal antibodies registered in the Czech Republic, whose stage III studies had been concluded before December 31, 2008. Main findings An overview of concluded stage three studies of all registered indications for seven tumour antibodies have been created including alemtuzumab, bevacizumab, cetuximab, ibritumomab tiuxetan, panitumumab, rituximab and trastuzumab. Considering the brief use of Mab in the medical practice, many of the studies have not been finished or their results are still to be published. Judging from the overview, the scope of indication of some monoclonal antibodies rises depending on the duration of their use. At the beginnings of therapeutic use, mainly for ethical reasons, monoclonal antibodies were applied to patients with later stages of the disease. The increasing amount of information on effectiveness and safety of the treatment as part of the research has enabled the use of biological treatment in earlier stages of tumour diseases and also in the adjuvant therapy. In comparison with the...
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Concept of "nature" in Montesquieu's Spirit of the Laws
Fořtová, Hana ; Kučera, Rudolf (advisor) ; Čapek, Jakub (referee) ; Pechar, Jiří (referee)
The aim of the dissertation is to clarify concept of nature in the major work of Montesquieu, The Spirit ofthe Laws. In fact we cannotfully comprehend political theory of the author without a proper understanding of his conception of human nature. The majority of interpreters treating this question regard Montesquieu as a follower of the modern school of natural law, mainly Grotius and Pufendorf, and they focus their attention on concepts of "natural right" and "natural law". Nevertheless, Montesquieu employs these terms rarely and he prefers to speak simply of "nature"; moreover, he does not offer a systematic analysis of the concept of natural right, neither any elaborate theory of human nature. The general notion of "nature" enables usto explore the scientific meaning of this term covering theory of climate, as one of the central points of author's politicaltheory. The first part of dissertation analyses the scientific meaning of the concept of nature. Through his activities at Bordeaux Academy Montesquieu was not only a spectator of the scientific revolution but he played the role of an active participant in this field. We focused on the author's attitude to the new idea of nature, mainly with regard to his attempt to understand human body. Montesquieu shares the Cartesian mechanistic conception of...
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Role of Middle Management in Innovation Process
Novák, Adam ; Nový, Ivan (advisor) ; Pauknerová, Daniela (referee) ; Vraný, Jan (referee)
Middle managers operate in an environment close to activities of their firm and in interaction with this environment identify opportunities, challenges, and subsequently generate innovation alternatives. While doing so they - among other - utilize also weak ties within their social network, which permeate internal and external environment of the firm and enable entry of new and divergent information in the innovation process. Middle managers communicate selected information to senior management levels, and the communication exchange between the middle and top management facilitates compliance with the firms innovation strategy, ensures resources as well as high level support for the implementation of innovation; middle managements information inputs at the same time influence senior management in defining the firms innovation strategy. In contact with ordinary employees (and lower levels of management), middle management compensates for differences between strategy and current activities of the firm, promotes innovation and overcomes resistance. To ensure support for innovation within the organization, middle managers draw, inter alia, on their internal networks of strong ties, including their informal components. Middle management acts as a communication bridge, which helps to balance the tensions originating from the differences between environments of the senior management and employees. From this perspective, the communication interfaces between the different levels of management, or the companys hierarchy, seem to play a critical role; my research at the same time indicates there are significant differences in perception between middle and senior management of intracompany processes enabling innovation.
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Performance budget in concrete conditions cities Jicin
Knápek, Petr ; Nováková, Štěpánka (advisor)
Subject my baccalaureate work is " Performance budget in concrete conditions cities Jicin". This work deal with problems performance budget cities Jicin in the area receipts and expenses in time year 2006 and 2007, their mutual juxtaposition and further production and usage funds. Is articulate into two parts, theoretic and practical. Aim theoretic parts is adumbration given to problemsthat the treat of endeavour put near position and action municipality, individual authorities municipality and their activity, further then common problems economy and budget municipality. Practical part is devoted town Jicin. At the beginning looking back behind story cities, further pay analysis budget cities. First try analyze budget revenue cities, after it supplies. Part pay income from operations cities in single years tracked period and lastly draw up information on production and usage funds.
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