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Synchronization of circadian system during prenatal and early postnatal development
Houdek, Pavel ; Sumová, Alena (advisor) ; Novotná, Růžena (referee)
One of the few attributes common to almost all living organisms is an ability to generate and maintain endogenous rhythms, which are controlled by a biological clock. The processes, which recur with a period of about 24 hours, are known as the circadian rhythms. The circadian clock controls rhythms of molecular, physiological as well as behavioral processes and adapts their activity to regularly appearing changes in day and night or season. In case of mammals, central oscillator is located in the hypothalamic suprachiasmatic nuclei (SCN). The SCN clock entrains rhythms of peripheral oscillators located in cells of other tissues. The central oscillator itself is synchronized with external environment mainly by a light-dark cycle, however, other cues can entrain the SCN clock as well. For example, during prenatal development, entrainment of a fetal clock is entirely dependent on non-photic cues derived from maternal organism. This study aimed to investigate a mechanism of the communication between the maternal and fetal central oscillators. A hypothesis was tested whether maternal melatonin may play a role in entrainment of the circadian clock in the fetal SCN. Furthermore, a mechanism, how melatonin may entrain the fetal clock was investigated at molecular level. The results provided evidence, that...
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The role of radiographer as the paramedical staff in the health of patients in defined competencies
ŠKRABALOVÁ, Jana
The topic of the thesis is "The role of a radiology assistant as a paramedical staff in patients health care within defined competencies." The aim of this work is to summarize global information about radiological assistant competencies, as they may be executed in patient care in practice and how these competencies have increased with new Decree No. 55/2011 Coll. Another objective of this study is to compare educational programs of specialized education. Hypothesis have been formulated as follows: In the amended Decree, radiology assistant competencies have increased. The information that this work provides, primarily relate to legal standards and their comparison. Feedback to legislation has been identified in the survey. Questionnaires provided information about radiology assistants satisfaction with their competencies, qualifications, conferences benefits and educational specialization. In the discussion there are evaluated gained informations and opinions on the topic. Conclusion then summarizes all findings related to the research.
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Comparison of sequence variations in genes of biotransfromation enzymes in some carcinoma
Turková, Lucie ; Tavandzis, Spiros (referee) ; Bóday, Arpád (advisor)
Xenobiotic biotransformation process and its capacity is crucial for xenobiotic chemicals elimination that may cause damage toward cell structures. The effectiveness of the enzymes included in this process depends on the gene variants that encodes them. The aim of this work was to compare certain polymorphisms of selected genes between cases and control groups. Studied polymorphisms were null genotypes of the glutathione S-transferase gene M1 and T1 and the insertion of TA dinucleotide in the promotor region of UDP-glucuronosyl transferase 1A1. The number of cases group was six included patients with colorectal, lung, prostate, breast, pancreatic and head and neck cancer. Total number of analysed individuals was 1 118 for cancer cases and 470 for healthy controls. The control group was divided into two groups, the first one was called general and the second one was called special included healthy individuals with no cancer history in their closest family members. Gilbert syndrome (GS) is caused by homozygous insertion of the TA dinucleotide in the TATA box of the gene UGT1A1 and it causes elevated bilirubin levels. Bilirubin is a potent antioxidant in human body, so the aim was to attest its protective effect toward cancer. We expected lower frequency of GS as a protective factor in the cases groups compared with controls. This hypothesis was confirmed in the breast cancer group (GS frequency 10,0 %) and pancreatic cancer group (GS frequency 11,1 %). In the general and special control groups the frequency of GS was 16,0 % and 15,4 % respectively. Although the other case groups show lower frequency of GS, the results weren´t statistically significant. Null GSTM1 genotype was observed with 50,4 % frequency in the general control groups and with 55,3 % frequency in the special control group. Neither the one of the cases groups hasn´t showed significantly lower percentage of null genotype. Despite expectation we observed statistically significant lower frequency of null genotype in the group of lung and pancreatic cancer group (37,4 % and 39,3 % respectively). According to this study, we can say that the lack of glutathione S-transferase M1 activity is not a risk factor for cancer development. Null genotype of GSTT1 wasn´t identified in both control groups at all. In case groups of breast and prostate cancer, there was only one individual carrying the null GSTT1 genotype. Statistically significant higher frequency of this polymorphism was observed in patients with colorectal cancer (9,7 %), lung cancer (17,2 %), pancreatic cancer (3,0 %) and head and neck cancer (15,9 %). In these groups the lack of glutathion S-transferase T1 activity might be considered as risk factor for cancer development. Nevertheless, for further verification it needs to take more investigation in this field, especially enlarge the number of patient in the case groups of head and neck, lung and pancreatic cancer.
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The Impact of the Far Eastern Philosophy on the Gastronomy
Sopúchová, Dana ; Mlejnková, Lena (advisor) ; Netková, Jarmila (referee)
The aim of this study is to identify the characteristics of the impact of the philosophy on the gastronomy in the Far East Region. The first part of the study is focused on the definition of the gastronomy and the philosophy. The Traditional Chinese Medicine is characterized in the second part. In the third part there are samples of the impact of the philosophy on the gastronomy. The last part studies the hypothesis of the penetration of the eastern gastronomy to the West and spreading there the eastern philosophy.
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Political vision of V. Klaus
Binar, Martin ; Prorok, Vladimír (advisor) ; Lisa, Aleš (referee)
The thesis analyses the thinking of Václav Klaus based on clashes with his rivals during his political career. The thesis works with hypothesis that Klaus is in this thinking connected with New Right, which was mainly present in world politics by Margaret Thatcher and Ronald Reagan. Values of Klaus are first analysed theoretically via analysis of conservatism, liberalism and finally their synthesis in so called New Right. Next part of the thesis provided evidence for hypothesis on national level, where Klaus was minister of finance and prime minister and third part on international level with Klaus as president of Czech republic. The hypothesis is confirmed at the end by summarizing evidence, which arose from particular chapters.
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Marketing research in audiovisual production: pretesting of television pilots
Sedláčková, Dagmar ; Kruml, Milan (advisor) ; TOMEK, Ivan (referee)
Marketing research in audiovisual production: pretesting of television pilots" aims to describe processes behind the creative portion of quality TV program creation.
TV stations often use so-called pre-testing in order to find out, based on a small number of viewers, whether the show will meet the station's demands and gain commercial success.
The thesis analyzes whether pretesting might be a powerful tool to positively influence future success of a TV show.
In individual chapters of the paper, the hypothesis is being proven or disproven, depending on factual examples and partial analyses.
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Hollywood mainstream marketing tools analysis
Vondráčková, Alexandra ; ŠVECOVÁ, Marta (advisor) ; KAŠPAROVSKÝ, Roman (referee)
This masters thesis titled "Hollywood mainstream marketing tools analysis: Has Hollywood marketing outrun the production itself?" aims to describe the state and issues of contemporary film marketing. It poses the question of whether the marketing behind the films is so sophisticated that it gets ahead of the movies. Furthermore, the thesis deals with the fact that this excessive attention to endless refinement of promotional materials for the film - together with the individual marketing tools - ultimately harms the impression from the movie in the eyes of its viewers. They can often feel dissatisfied or even defrauded. This hypothesis is demonstrated and disproved on the basis of specific examples and partial analysis.
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Europeanization as a source of euroscepticism? Case study of Croatia
Chrtková, Kristýna ; Němec, Jan (advisor) ; Kný, Daniel (referee)
This thesis deals with the changes of elite and public euroscepticism in Croatia with the beginning of the last wave of democratization, from the year 2000 until nowadays. Croatia is an example of a country with a declining number of public EU supporters, when the date of the EU accession approached. In contrast to the public opinion, the attitudes of dominant part of the political elite was typically a strong EU support. This bachelor thesis aims at proving the hypothesis that the source of the Croatian euroscepticism is europeanization. Therefore the integration process of Croatia is researched focusing on changes made by the EU as well as particular problematic cases that have decelerated the accession process and negatively affected the perception of the EU. Furthermore, the thesis contains a survey of attitudes to the EU presenting opinions of selected Croatian political parties and Croatian public. Special attention is devoted to capturing the overall picture of Croatian's society attitude towards the EU.
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Bailouts in banking industry : Curse or salvation?
Šolc, Jan ; Janda, Karel (advisor) ; Hedbávný, Petr (referee)
One of questions discussed in the light of current financial crisis is the problem bailouts in banking industry. This thesis contributes to this dispute by studying the relationship between the probability to be bailed out and the risk appetite of particular commercial bank. The aim of this paper is to analyze this relationship in both, theoretical and empirical way, which is still missing in current literature. We work with two hypotheses in this paper. The first one is that there is a positive relationship between the above mentioned variables while the second one suggests that large commercial banks tend to have higher risk appetite. Our first hypothesis is studied in both ways, while the second one is analyzed only in a theoretical way. In the theoretical part we derive the relationships between considered variables under the general equilibrium framework. In our model we work with an economy with four different agents (namely households, firms, commercial banks and central bank). These derived relationships are then analyzed empirically. We work with a panel data dataset considering the data about 500 commercial banks from 70 countries over the 2005-2008 period. The results of empirical analysis suggest that there is a negative relationship between the probability to be bailed out and the risk...
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Plánování a management nástupnictví v mezinárodních organizacích - případová studie UniCredit Group
Harutyunyan, Zaruhi ; Pauknerová, Daniela (advisor) ; Králová, Tereza (referee)
This thesis analyses Succession Planning and Management practices in international organizations, and specifically in UniCredit Group, with the goal of developing recommendations for improvement of UniCredit Group's existing practice. The theoretical part provides background knowledge about generics of succession planning and management, its evolution and connection with other Human Resource processes. It is followed by highlights of acclaimed best practices in mitigating risks in implementing succession planning and management systems. The latter acts as a beginning of the practical background of the thesis, as the empirical study aims at discovering strengths and weaknesses of the UniCredit Group in comparison with the theoretical models and the best practices presentation. Based on the latter, qualitative research has been conducted in cooperation with UniCredit Group's Central and Eastern Europe Sub-holding level HR Business Partners and Specialists. The hypothesis that UniCredit Group has a well-established succession planning and management system (up to the most possible comparison with theoretical models and best practices) has been confirmed. The analysis and synthesis of the results from both the theoretical and empirical part are the basis, on which recommendations have been developed.
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