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Synthesis and comparison of activity of potential reactivators of acetylcholinesterase inhibited by cyclosarine
Lipka, Lukáš ; Doležal, Martin (advisor) ; Kučerová, Marta (referee)
SYNTHESIS OF POTENCIAL QUATERNARY ACETYLCHOLINESTERASE REACTIVATORS AND EVALUATION OF THEIR POTENCY TO REACTIVATE CYCLOSARIN-INHIBITED AChE Mgr. Lukáš Lipka Department of pharmaceutical chemistry and drug control, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic Abstract of the rigorous thesis: Nine potential AChE reactivators were synthesized. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the obtained results, 1,4- bis(2-hydroxyiminomethylpyridinium)butane dibromide seems to be most potent AChE reactivator. The reactivation potency of these compounds depends on structural factors such as presence of quaternary nitrogens, lenght of the linking chain between both pyridinium rings, and position of the oxime moiety at the pyridinium ring. The independence of potency of reactivator trimedoxim at the kind of anion present in his molecule was validate.
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Educational and Diagnostic Potentials of the Surroundings Cobwebs in Classes in Classes of Pupils at the Age 3rd and 4th Year of Elementary School
Fialová, Hana ; Hejný, Milan (advisor) ; Bomerová, Eva (referee)
The Diploma Thesis presents the outcomes of the research based on solving the tasks of a mathematical surroundings Cobwebs by the pupils of the 3rd and the 4th classes of elementary school. The first chapter defines the surroundings from the mathematical point of view, the chapter two deals with the didactic application of Cobwebs. Interesting pieces of phenomenon occurred in the experiments and its roots are described in the following chapter as well as the results of a quantitative experiment. The last part of the thesis shows a course of the workshop at the conference Dva dny s didaktikou matematiky 2009 in Prague and describes the participants' comments to the surroundings of Cobweb tasks. The supplements include an elaboration of the experiments containing the protocol, evidence, comments, the cascade of the tasks and the video recording.
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Family as factor influencing socially - patological behaviour of the child
Brzobohatý, Ladislav ; Vítečková, Michaela (referee) ; Lorenzová, Jitka (advisor)
Diploma work "Family as factor influencing socially-patological behaviour of the child" is compiled teoretical ly and scienti fically. Teoretical part deal in fami ly and its relations concerned. Prel iminarily it describes some patological phenomenons which signi ficantly influnce the development of the family.Basic functions of family as well as its fail rures are desribed.Also some of undesi rable mani festations of behaviour of particular members of family are desribed.Teoretical part of diploma work shows the relation between disfunction of the family and inception of patological behaviour of individuals.Suicide,missuse of drugs,problems connected with deliquent behaviour and penitenciar t reatment are evaluated as the most dangerous for human and for the society as a whole. A.m. conclusions are followed by empi rical part.Empi rical part examines number of some fami ly factors in anamnesis of young imprisoned persons.Particularily informations about completness and functionality of families of these individuals are examined. Furthermore this part concentrates on monitoring of emotional relation of parents to thei r deliquent chlidren and at the same time the way of upbringing is monitored. The summary comprises both theoretical conlusions as well as conlusions based on informations coming from the...
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Modern reverse stationary phases based on silicagel, zirconium dioxide and organic monoliths: application to analysis of biologically active compounds
Soukupová, Klára
Charles University in Prague Faculty of Science Department of Analytical Chemistry Modern Reversed Stationary Phases Based on Silicagel, Zirconium Dioxide and Organic Monoliths; Their Used in Separation of Biologically Active Compounds Synopsis of PhD. Thesis Prague 2008 Klára Soukupová The PhD. Thesis was carried out at the Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, in the period of 2003-2008. Author: Mgr. Klára Soukupová Supervisors: RNDr. Jana Suchánková-Sobotníková, Ph.D Doc. RNDr. Eva Tesařová, CSc. Prague 2008 1 Table of contents 1. Introduction 2 2. Objectives of the Thesis 3 3. Results and Discussion 4 4. Conclusions 12 5. References 13 Appendix 1: List of Publications, Lectures and Poster presentations 14 Appendix 2: Curriculum Vitae 16 2 1. Introduction High performance liquid chromatography (HPLC) is modern instrumental method used mainly in analytical chemistry. Most used separation mode is reversed phase liquid chromatography (RP HPLC). This method is very useful because of high separation efficiency, reliability and wide choice of stationary phases with different selectivity. Most used stationary phases in RP HPLC are bonded phases, which have many advantages: good availability, wide application range, fast establishment of equilibrium and ability to...
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Modern reverse stationary phases based on silicagel, zirconium dioxide and organic monoliths: application to analysis of biologically active compounds
Soukupová, Klára ; Sobotníková, Jana (advisor) ; Pacáková, Věra (referee) ; Cvačka, Josef (referee)
Charles University in Prague Faculty of Science Department of Analytical Chemistry Modern Reversed Stationary Phases Based on Silicagel, Zirconium Dioxide and Organic Monoliths; Their Used in Separation of Biologically Active Compounds Synopsis of PhD. Thesis Prague 2008 Klára Soukupová The PhD. Thesis was carried out at the Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, in the period of 2003-2008. Author: Mgr. Klára Soukupová Supervisors: RNDr. Jana Suchánková-Sobotníková, Ph.D Doc. RNDr. Eva Tesařová, CSc. Prague 2008 1 Table of contents 1. Introduction 2 2. Objectives of the Thesis 3 3. Results and Discussion 4 4. Conclusions 12 5. References 13 Appendix 1: List of Publications, Lectures and Poster presentations 14 Appendix 2: Curriculum Vitae 16 2 1. Introduction High performance liquid chromatography (HPLC) is modern instrumental method used mainly in analytical chemistry. Most used separation mode is reversed phase liquid chromatography (RP HPLC). This method is very useful because of high separation efficiency, reliability and wide choice of stationary phases with different selectivity. Most used stationary phases in RP HPLC are bonded phases, which have many advantages: good availability, wide application range, fast establishment of equilibrium and ability to...
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Transdermal in vitro permeation of methoxytacrine. III.
Režňáková, Eva ; Doležal, Pavel (advisor) ; Bajgar, Jiří (referee)
Diploma Thesis 2006, Eva Režňáková Abstract The theoretical part gives a list of selected issues on transdermal drug delivery and summarizes information on Azone, including new technical information published in 2005. In vitro permeation experiments using the excised pig skin confirm the considerable potential for transdermal administration of 7-methoxytacrine. Using the isopropyl myristate as a vehicle the therapeutically valuable fluxes at about 15 [μg/cm2.h-1] were obtained. Transdermal acceleration and impact of 5% added amounts of methyl pyrrolidone and dodecyl pyrrolidone were not established. As a promising in this respect appears to use Azone and transkarbam 12.
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Analysis of students' results of the subject 4ST201
Šulc, Zdeněk ; Malá, Ivana (advisor) ; Helman, Karel (referee)
The main aim of this bachelor thesis is to compare and to test the results of students, who attended the course of statistics at the University of Economics in Prague. The thesis is divided into theoretical and practical part. The theoretical part explains basic methods which are used in the thesis. The practical part deals with an analysis which is mainly focused on mid-term tests. The results of this thesis are summarized in the conclusion.
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Art Education in Japan/School - ethnographic study
Karpetová, Barbora ; Slavík, Jan (advisor) ; Horáček, Radek (referee) ; Babyrádová, Hana (referee)
Tato práce zkoumá japonskou výtvarnou výchovu jako vyučovací předmět. Reflektuje jak po stránce formální, tak obsahové japonský vzdělávací systém a rovněž umožňuje vhled do různých vrstev japonské kultury. Výzkum byl veden kombinací metod pedagogicko-etnografických a kulturně- antropologických. Informace čerpal především z terénního výzkumu prováděného v Japonské škole v Praze a v některých školách v Japonsku v Ósace v letech 1986-2006. Kromě podrobné analýzy osnov, učebnic, náplně práce učitele a historie vývoje výtvarné výchovy se tato práce věnuje odlišnému chápání tvořivosti, která je v Japonsku vnímána především jako kolektivní kontinuální proces, jemuž mohou být nápomocni všichni členové společnosti. Iniciaci tvořivých "mechanismů" napomáhají mimo jiné i metody výuky, které se nezasvěcenému pozorovateli jeví jako netvořivé kopírování. Právě v tomto bodě dochází nejčastěji k nedorozumění a konfrontaci se západním pojetím. Jedním z cílů t é to práce je tento problém osvětlit, a obohatit tak naše znalosti geneze tvořivých procesů. S postupující globalizací a asimilací kultur vyvstává potřeba "mezinárodní výchovy". Nutnost hledání základních postupů vedoucích k poznání a pochopení jiných kultur. Výchova k empatii vůči příslušníkům jiných národů a jejich specifickým projevům. I v tomto směru tato práce...
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Spiritual Guidance
Bártová, Darina ; Filipi, Pavel (advisor) ; Noble, Ivana (referee)
The work deals with spiritual guidance.Concept of spiritual gudiance and related concepts is defined first. Next the spiritual accompaniment is defined against the sacrament of reconciliation on the one hand and to psychological counseling on the other. The paper tries to show that the concept of spiritual accompaniment is rooted in the tradition of Christian spirituality.It is possible to interpret some biblical stories from this perspective. But some personalities of the history of spirituality also contributed to the current conception of spiritual accompainment. Own capter is dedicated to them. The following is a more detailed analysis of the content and typical forms of spiritual guidance, requirements for accompanying and specifics of various categories of accompanied. Some pathological phenomena in the context of spiritual accompaniment appear are mentioned also. The results of field research in selected communities of different denominations are a separate part of the work. They have demonstrated wheather the concept of spiritual accompaniment is known and wheather it is used and by whom. An important question is also characteristic of the typical accompanying. The research results are summarized in the conclusion and in the annexes. Powered by TCPDF (www.tcpdf.org)
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Marriage and family in the New Testament
Kryczka, Katarzyna ; Hřebík, Josef (advisor) ; Brož, Jaroslav (referee)
Marriage is God `s wanting and blessed relationship between man and woman. Already with creation God assigned humane creature to be equal even though they are different. God creatured man and woman to be for each other love each other and support each other. Example for them have to be God`s love to his chosen people, whom he loves with unconditional love. Wedlock is a sacrament sacred and holly. According the Bible teaching, monogamy and unfaithfulness are sin. Child is for the couple God`s gift, whom he is blessing, loves and have a special plan for. Children are blessings and pride of the parents. Family with many children is assurance for keeping faith and be strong and together at time of suffering. Family is participation in God`s creature. Responsibilities for each member in the family, helps matured each person. Husband and father have the responsibility for his wife and children before God and society. He also is commissioned to secure financially the family and support their traditions and religious life. Woman as a mother and wife with caring love arranges home for her children and husband. She is can not be subjected to her husband, as we learned unfortunately from the history, because that's against God wish. Marriage as a gift and also commission could be an example for today's modern...
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