Národní úložiště šedé literatury Nalezeno 15 záznamů.  1 - 10další  přejít na záznam: Hledání trvalo 0.01 vteřin. 
Candida species and antimicrobial peptides from the venom of different wild bees
Slaninová, Jiřina ; Borovičková, Lenka ; Putnová, H. ; Monincová, Lenka ; Fučík, Vladimír ; Čeřovský, Václav
We describe activity of new peptides named Lasioglossins and their analogues against the yeast species C.albicans, C.glabrata, C.tropicalis, C.krusei and C.parapsilosis. The most active peptides showed MIC between 5-10 .mu.M.
Melectin analogues: The influence of dendrimerization on antimicrobial and hemolytic activity
Niederhafner, Petr ; Šafařík, Martin ; Ježek, Jan ; Borovičková, Lenka ; Bednárová, Lucie ; Fučík, Vladimír ; Čeřovský, Václav ; Slaninová, Jiřina
Dimers and tetramers of MEP and MEP derivatives were synthesized on Fmoc-Lys(Fmoc)-Rink amide resin, the tetramer was obtained from the dimer C-terminally extended via Cys-Cys linkage. In general, the dendrimerization of MEP led to an increase of haemolytic activity but did not improve substantially its antimicrobial properties.
Novel biologically active peptides from the venom of the solitary bee Macropis fulvipes (HYMENOPTERA: MELITTIDAE)
Monincová, Lenka ; Slaninová, Jiřina ; Voburka, Zdeněk ; Hovorka, Oldřich ; Fučík, Vladimír ; Borovičková, Lenka ; Bednárová, Lucie ; Buděšínský, Miloš ; Straka, J. ; Čeřovský, Václav
Two peptides (macropine-1 and macropin-2) were isolated, their structure determined by Edman degradation and mass spectrometry, which exhibited potent antimicrobial activity against both Gram-positive and -negative bacteria and moderate hemolytic activity against rat erythrocytes. We prepared several MAC-1 analogs to study the effect of their structure on antimicrobial and hemolytic activities.
New peptides with antimicrobial activity isolated from the venom of the bumblebee Bombus pascuorum (Hymenoptera: Apidae)
Ježek, Rudolf ; Janechová, D. ; Cvačka, Josef ; Slaninová, Jiřina ; Voburka, Zdeněk ; Hovorka, Oldřich ; Fučík, Vladimír ; Borovičková, Lenka ; Maloň, Petr ; Čeřovský, Václav
Six new heptadecapeptides were isolated and synthesized by standard Fmoc solid phase peptide synthesistogether with several structural analogues. Antimicrobial activities were correlated with the peptides hydrophobicity, hydrophobic moment, alpha-helicity and HPLC retention time.
In vitro and in vivo studies of the neuroprotective peptide humanin using 125I-radiolabeled humanin derivatives
Evangelou, A. ; Zikos, C. ; Benaki, D. ; Pelecanou, M. ; Bouziotis, P. ; Papadopoulos, M. ; Borovičková, Lenka ; Veselá, Iva ; Elbert, Tomáš ; Kunešová, G. ; Pirmettis, I. ; Paravatou-Petsotas, M. ; Slaninová, Jiřina ; Livaniou, E.
Four new HN-derivatives were synthesized: Y-PAGASRLLLTGEIDLP (Y-des-Leu-RG-PAGA, 1), Y-PAGASRLLLLTGEIDLP (Y-RG-PAGA, 2), Y-SALLRSIPAPAGASRLLLTGEIDLP (Y-des-Leu-Colivelin, 3), Y-SALLRSIPAPAGASRLLLLTGEIDLP (Y-Colivelin, 4), their neuroprotective action was evaluated in the T-maze test and the most active ones were monoradioiodinated with 125I and the labelled peptides used for binding and biodistribution studies.
Short peptides with antimicrobial activity from plants
Doležílková, Ivana ; Macková, M. ; Macek, Tomáš
Several families of plant antimicrobial peptides have been isolated from different organs and intercellular washing fluids of plants. Antimicrobial peptides were isolated by precipitation of fractions and separared by HPLC and then characterized by tricine electrophoresis.
Peptides with an antimicrobial activity isolated from the larvae of the fleshfly Neobellieria bullata
Neubauerová, Tereza ; Macková, M. ; Macek, Tomáš ; Šanda, Miloslav ; Voburka, Zdeněk
Short cationic peptides play an important role in the innate immunity of all living organisms. Some of the 700 peptides described so far have become a potential source of new antibiotics to combat the increasing emergence of drug-resistant bacteria. Haemolymph of larvae of the fleshfly were chosen as a source of such peptides.
Specific binding of prolactin-releasing peptide analogues in pituitary cells
Maixnerová, Jana ; Špolcová, Andrea ; Matyšková, Resha ; Blechová, Miroslava ; Veselá, Iva ; Železná, Blanka ; Maletínská, Lenka
We report specific binding of 125I-PrRP31 to the following cell lines: GH3 cells (rat – somatotrophs), AtT20 cells (mouse – adenocorticotrophs) and RC-4B/C cells (rat- somatotrophs, lactrophs, adenocortitrophs and gonadotrophs). These results will serve as a basic knowledge for future structure-activity studie sof PrRP.
Delayed effects of a dipteran oostatic hormone on reproduction in the Tsetse fly
Žďárek, Jan ; Hlaváček, Jan ; Takáč, P.
Long-time delivery of the oostatic pentapeptide H-Tyr-Asp-Pro-Ala-Pro-OH decreased a fertility in the long-lived tse-tse fly G. Morsitans.
Analogues of Orn and DAP as potential inhibitors of bacterial enzymes ArgE and DapE
Hlaváček, Jan ; Pícha, Jan ; Vaněk, Václav ; Jiráček, Jiří ; Slaninová, Jiřina ; Fučík, Vladimír ; Gilner, D. ; Holc, R. C.
The series of ornithine and diaminopimelic acid derivatives were prepared. Some of the compounds are inhibitors of enzymes, which catalyze formation of bacterial precursors.

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