2025-01-19
00:08 |
PHYSICAL STABILIZATION OF WATER-SOLUBLE PVA NANOFIBROUS MATERIALS FUNCTIONALIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
Lisnenko, M. ; Holeček, M. ; Kuželová Košťáková, E. ; Valtera, J. ; Rejman, Dominik ; Müllerová, J. ; Běhálek, L. ; Jenčová, V.
Tissue engineering aims to develop materials that enhance biological activity and promote tissue healing and regeneration. One promising approach is to functionalize nanofibrous materials with antimicrobial substances, such as lipophosphonoxin (LPPO), and use water-soluble polymers like polyvinyl alcohol (PVA) to incorporate bioactive molecules into fibers. However, water-soluble materials often face the issue of burst release, releasing over 90% of the active substances within the initial 24 hours. This research focuses on preparing functionalized nanofibrous materials based on PVA containing the experimental antimicrobial compound LPPO and subsequent physical stabilization of the materials using the Heat treatment method. The applied stabilization successfully reduced the incorporated substance's release rate by up to 50%. The resulting materials have the potential to provide functional cross-linked PVA nanofiber scaffolds for regenerative medicine applications in large and chronic skin injuries.
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2025-01-12
00:00 |
Hmotnostní spektrometrie ve strukturní analýze lipidů
Cvačka, Josef
Přednáška na konkrétních příkladech ukazuje využití hmotnostní spektrometrie pro určování struktury lipidů v různých typech biologických vzorků. Diskutovány jsou nové analytické postupy, které zahrnují chemickou derivatizaci a fragmentaci iontů v plynné fázi s využitím různých aktivačních technik.
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2025-01-12
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2024-11-02
00:00 |
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2024-03-10
03:13 |
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2023-12-17
00:02 |
NIVB Meeting 2023
Hostomský, Zdeněk ; Vácha, R. ; Pichová, Iva ; Šímová, Šárka
NIVB Meeting 2023 – the second meeting of the National Institute of Virology and Bacteriology (NIVB) in Kutná Hora on 2. 10. – 5. 10. 2023 will be again after one year an opportunity to meet the participating teams, discuss excellent science, establish collaborations, and present the progress of the project to the members of the International Scientific Advisory Board. Thanks to funding from the Czech Economic Recovery Plan, a number of important results have already been published in high impact journals. Several networking workshops have been organized and scientific collaborations have been established. The meeting in Kutná Hora is therefore a summary of all that has happened in the project over the past year. The main goal of the NIVB is to facilitate cooperation between 30 participating research teams from 8 Czech research institutions, and this goal is gradually being achieved. The NIVB acts as a common communication platform to discuss the desired cooperation of the NIVB research teams, especially those that have not had much contact so far due to their inter-institutional, interdisciplinary or inter-regional distance.\nWe thank all the participants who contributed to the meeting with 30 oral presentations and 67 posters. The NIVB 2022 meeting had the ambition to launch a new series of annual meetings dedicated to virology and bacteriology, and NIVB 2023 fulfils this ambition and continues to aim to inform the wider scientific community about new developments, trends and issues in these disciplines.
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2023-11-19
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2023-11-19
00:04 |
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2023-11-19
00:04 |
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2023-11-12
00:02 |
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