Název: Analysis and physico-chemical characterization of peptides and lipopeptides regulating food intake by capillary electrophoresis and isotachophoresis
Autoři: Šolínová, Veronika ; Křížková, Adéla ; Maletínská, Lenka ; Kašička, Václav
Typ dokumentu: Příspěvky z konference
Konference/Akce: Advances in Chromatography and Electrophoresis & Chiranal 2024, Olomouc (CZ), 20240617
Rok: 2024
Jazyk: eng
Abstrakt: New lipidized analogs of peptides (ghrelin, prolactin-releasing peptide (PrRP) and cocaine- and amphetamine-regulated transkript peptide (CARTP)) are studied for regulation of food intake.\nGhrelin (28 amino acids) is native peptide hormone, which is secreted in the stomach and acts both peripherally and centrally [1]. PrRP (31 amino acids) was discovered as a ligand for an\norphan G-protein coupled receptor GPR 10 and as a regulator of prolactin release [2]. The CARTP (42 amino acids) is a brain-born and brain-acting neuropeptide with anorexigenic properties regulating hormone leptin [3]. The inability of these peptides to cross blood-brain barrier to their target receptors may be overcome by their lipidization at biologically inactive sites of their molecules. The set of ten (lipo)peptides was synthesized to be tested as potential drugs. Prior their application, they have to be analyzed and characterized. For that reason, the aim of this work was to check their purity and to characterize their acid-base properties by capillary zone electrophoresis (CZE) and capillary isotachophoresis (CITP).
Klíčová slova: capillary electrophoresis; capillary isotachophoresis; lipopeptides
Zdrojový dokument: Advances in Chromatography and Electrophoresis & Chiranal 2024, ISBN 978-80-244-6478-7

Instituce: Ústav organické chemie a biochemie AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný na externích webových stránkách.
Externí umístění souboru: https://doivup.upol.cz/pdfs/doi/9900/06/7500.pdf
Původní záznam: https://hdl.handle.net/11104/0365817

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-678766


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav organické chemie a biochemie
Konferenční materiály > Příspěvky z konference