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Original title:
Analysis and physico-chemical characterization of peptides and lipopeptides regulating food intake by capillary electrophoresis and isotachophoresis
Authors: Šolínová, Veronika ; Křížková, Adéla ; Maletínská, Lenka ; Kašička, Václav
Document type: Papers
Conference/Event: Advances in Chromatography and Electrophoresis & Chiranal 2024, Olomouc (CZ), 20240617
Year: 2024
Language: eng
Abstract: New lipidized analogs of peptides (ghrelin, prolactin-releasing peptide (PrRP) and cocaine- and amphetamine-regulated transkript peptide (CARTP)) are studied for regulation of food intake.\nGhrelin (28 amino acids) is native peptide hormone, which is secreted in the stomach and acts both peripherally and centrally [1]. PrRP (31 amino acids) was discovered as a ligand for an\norphan G-protein coupled receptor GPR 10 and as a regulator of prolactin release [2]. The CARTP (42 amino acids) is a brain-born and brain-acting neuropeptide with anorexigenic properties regulating hormone leptin [3]. The inability of these peptides to cross blood-brain barrier to their target receptors may be overcome by their lipidization at biologically inactive sites of their molecules. The set of ten (lipo)peptides was synthesized to be tested as potential drugs. Prior their application, they have to be analyzed and characterized. For that reason, the aim of this work was to check their purity and to characterize their acid-base properties by capillary zone electrophoresis (CZE) and capillary isotachophoresis (CITP).
Keywords: capillary electrophoresis; capillary isotachophoresis; lipopeptides
Host item entry: Advances in Chromatography and Electrophoresis & Chiranal 2024, ISBN 978-80-244-6478-7
Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: https://doivup.upol.cz/pdfs/doi/9900/06/7500.pdf
Original record: https://hdl.handle.net/11104/0365817
Permalink: http://www.nusl.cz/ntk/nusl-678766
The record appears in these collections:
Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
Authors: Šolínová, Veronika ; Křížková, Adéla ; Maletínská, Lenka ; Kašička, Václav
Document type: Papers
Conference/Event: Advances in Chromatography and Electrophoresis & Chiranal 2024, Olomouc (CZ), 20240617
Year: 2024
Language: eng
Abstract: New lipidized analogs of peptides (ghrelin, prolactin-releasing peptide (PrRP) and cocaine- and amphetamine-regulated transkript peptide (CARTP)) are studied for regulation of food intake.\nGhrelin (28 amino acids) is native peptide hormone, which is secreted in the stomach and acts both peripherally and centrally [1]. PrRP (31 amino acids) was discovered as a ligand for an\norphan G-protein coupled receptor GPR 10 and as a regulator of prolactin release [2]. The CARTP (42 amino acids) is a brain-born and brain-acting neuropeptide with anorexigenic properties regulating hormone leptin [3]. The inability of these peptides to cross blood-brain barrier to their target receptors may be overcome by their lipidization at biologically inactive sites of their molecules. The set of ten (lipo)peptides was synthesized to be tested as potential drugs. Prior their application, they have to be analyzed and characterized. For that reason, the aim of this work was to check their purity and to characterize their acid-base properties by capillary zone electrophoresis (CZE) and capillary isotachophoresis (CITP).
Keywords: capillary electrophoresis; capillary isotachophoresis; lipopeptides
Host item entry: Advances in Chromatography and Electrophoresis & Chiranal 2024, ISBN 978-80-244-6478-7
Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: https://doivup.upol.cz/pdfs/doi/9900/06/7500.pdf
Original record: https://hdl.handle.net/11104/0365817
Permalink: http://www.nusl.cz/ntk/nusl-678766
The record appears in these collections:
Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
Record created 2025-04-20, last modified 2025-05-03