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Název:
PHYSICAL STABILIZATION OF WATER-SOLUBLE PVA NANOFIBROUS MATERIALS FUNCTIONALIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
Autoři: Lisnenko, M. ; Holeček, M. ; Kuželová Košťáková, E. ; Valtera, J. ; Rejman, Dominik ; Müllerová, J. ; Běhálek, L. ; Jenčová, V.
Typ dokumentu: Příspěvky z konference
Konference/Akce: NANOCON 2023 - International Conference on Nanomaterials - Research & Application /15./, Brno (CZ), 20231018
Rok: 2024
Jazyk: eng
Abstrakt: Tissue engineering aims to develop materials that enhance biological activity and promote tissue healing and regeneration. One promising approach is to functionalize nanofibrous materials with antimicrobial substances, such as lipophosphonoxin (LPPO), and use water-soluble polymers like polyvinyl alcohol (PVA) to incorporate bioactive molecules into fibers. However, water-soluble materials often face the issue of burst release, releasing over 90% of the active substances within the initial 24 hours. This research focuses on preparing functionalized nanofibrous materials based on PVA containing the experimental antimicrobial compound LPPO and subsequent physical stabilization of the materials using the Heat treatment method. The applied stabilization successfully reduced the incorporated substance's release rate by up to 50%. The resulting materials have the potential to provide functional cross-linked PVA nanofiber scaffolds for regenerative medicine applications in large and chronic skin injuries.
Klíčová slova: functionalization; heat treatment; nanofibrous materials; polyvinyl alcohol; tissue engineering
Zdrojový dokument: NANOCON Conference Proceedings - International Conference on Nanomaterials, ISBN 978-80-88365-15-0, ISSN 2694-930X
Poznámka: Související webová stránka: https://doi.org/10.37904/nanocon.2023.4793
Instituce: Ústav organické chemie a biochemie AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: https://hdl.handle.net/11104/0361684
Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-669200
Autoři: Lisnenko, M. ; Holeček, M. ; Kuželová Košťáková, E. ; Valtera, J. ; Rejman, Dominik ; Müllerová, J. ; Běhálek, L. ; Jenčová, V.
Typ dokumentu: Příspěvky z konference
Konference/Akce: NANOCON 2023 - International Conference on Nanomaterials - Research & Application /15./, Brno (CZ), 20231018
Rok: 2024
Jazyk: eng
Abstrakt: Tissue engineering aims to develop materials that enhance biological activity and promote tissue healing and regeneration. One promising approach is to functionalize nanofibrous materials with antimicrobial substances, such as lipophosphonoxin (LPPO), and use water-soluble polymers like polyvinyl alcohol (PVA) to incorporate bioactive molecules into fibers. However, water-soluble materials often face the issue of burst release, releasing over 90% of the active substances within the initial 24 hours. This research focuses on preparing functionalized nanofibrous materials based on PVA containing the experimental antimicrobial compound LPPO and subsequent physical stabilization of the materials using the Heat treatment method. The applied stabilization successfully reduced the incorporated substance's release rate by up to 50%. The resulting materials have the potential to provide functional cross-linked PVA nanofiber scaffolds for regenerative medicine applications in large and chronic skin injuries.
Klíčová slova: functionalization; heat treatment; nanofibrous materials; polyvinyl alcohol; tissue engineering
Zdrojový dokument: NANOCON Conference Proceedings - International Conference on Nanomaterials, ISBN 978-80-88365-15-0, ISSN 2694-930X
Poznámka: Související webová stránka: https://doi.org/10.37904/nanocon.2023.4793
Instituce: Ústav organické chemie a biochemie AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: https://hdl.handle.net/11104/0361684
Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-669200
Záznam vytvořen dne 2025-01-19, naposledy upraven 2025-01-19.