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Genetic risk factors of system autoimmune diseases
Bičíková, Adéla ; Daňková, Pavlína (advisor) ; Novota, Peter (referee)
One of the characteristics of systemic autoimmune diseases is the production of autoantibodies against self antigens. Genetic predisposition is supported by the HLA class II DQB and DRB genes, which constitute only about 40% of the risk. In the last few decades the search of other genetic risk factors noted major progress. There are many genetic risk factors that are shared by systemic disorders. These include genes such as PTPN22, STAT4, IRF5, TNFAIP3, TNFSF4, BANK1, BLK, CTLA4, genes coding for Fcγ receptors, FAS and others. Their presence suggests the existence of identical or similar mechanisms involved in the pathogenesis of autoimmune diseases. Conversely, many genetic factors predisposing to the development of the disease are specific to single system disorders. These genes often encode proteins involved in the functioning of the immune system, whether they are genes whose function has resulted in production of autoantigens (PADI4 and TREX1), or are responsible for the failure in selection of autoreactive T cells in the thymus (PTPN22), for antigen presentation to CD4+ T cells or cause the activation of autoreactive B cells (BANK1, IRF5, BLK).
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External Economic Analysisi of an Enterprise
Baroch, Václav ; Kyjonka, Vladimír (advisor) ; Král, Jaroslav (referee)
Automatizované zpracování ekonomické analýzy podniku přináší jistá omezení. Klasická von Neumannova architektura doznala v poslední době určitých vylepšení, a je tak možné simulovat procesy, jejichž algoritmické zpracování bylo ještě před pár lety z praktického hlediska nemyslitelné, především kvůli nedostatečné početní a paměťové výkonnosti užívané IT technologie. Přes všechna zrychlení a razantní vylepšení IT technologií v posledních letech však softwarové zpracování simulace podnikových procesů naráží na dvě podstatná omezení, jež jsou popsána v práci. Je to nemožnost vytvářet izomorfní model reality a nutnost řešit simulaci interních a externích procesů v diskrétním čase.
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Cold Waters, Hot Stakes: Systemic Geostrategic Analysis of International Relations in the Arctic Transborder Region
Valko, Irina ; Romancov, Michael (advisor) ; Hnízdo, Bořivoj (referee)
This work aims to fill the gap in the civil scientific agenda by offering its own, two- stage version of a systemic, dynamic, and interdisciplinary analysis of the developments in the Arctic transborder region; by fixing the region"s southern border at the Arctic Circle, adjusting to the premises of new geopolitics, using systemic modeling, and viewing geostrategic analysis as an obligatory academic contribution to the "art" of statecraft.The first stage of analysis is inductive, descriptive, and static. It defines the Arctic region as a system of five geostrategic action spaces, physical space (S1), military space (S2), economic space (S3), demographic space (S4), and information space (S5). After defining essential elements of the physical environment, social network analysis is applied on four human-constructed geostrategic spaces (S2-S5) - i.e. the basic networks of relationship (links) between the key actors (nodes) are created. Matrices of symmetrical relationships for military space (S2), economic space (S3), and demographic space (S4) are constructed to demonstrate the links" intensity. In order to illustrate the fact that changes in one action space ultimately transform other spaces, ten possible channels of inter-space affection are illustrated. The second stage of analysis is deductive,...
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Political endeavours of identitarian movements
Jarolím, Lukáš ; Sedláčková, Markéta (advisor) ; Šubrt, Jiří (referee)
Political endeavours of identitarian movements Abstract: Aim of this thesis is defining and analyzing identitarian movements via explorative approach. Identitarian movements are school of thought and authors, who are bound together by common enemy and common political goals. They do have political ambitions, but were not yet capable of making important changes. With the help of contextual theories and analysis of movements strategy this thesis will explore if identitarian movemenst are capable of political succes and why do they struggle in doing so.
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Web Portal for Consultation Meeting Management
Balcar, Juraj ; Szőke, Igor (referee) ; Beran, Vítězslav (advisor)
Consultation management system is for people, who want to reserve different dates at a doctor, consultant or manager, but also for the people, who want to offer consultation or office hours. The aim was the connection of functionality with simplicity and efficiency at the same time, which responds to user needs. In this work we can find the main things of request specification, system design and actual implementation.
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Application for Controll System in Caravan
Řehulka, Marek ; Novotný, Tomáš (referee) ; Kořenek, Jan (advisor)
This Master's thesis deals with the development of a mobile application for a control of the supervisory system in caravans and motorhomes. The thesis presents the currently available principles and research of the existing solutions. This custom solution includes an Android application and a desktop application of the central unit simulator of the supervisory system. The simulator is based on the Node.js and node-webkit technologies. The simulator communicates with the devices available via RF Transciever and it simulates other devices. The mobile application communicates with the simulator via Bluetooth Low Energy and GSM. Major part of the implementation description is devoted to the Bluetooth Low Energy technology and to issues, which are associated with it. The resulting solution puts emphasis on the usability of the user interface and the ability to supervise a wide range of connected devices. The system also implements custom logic alerts for tracked events. The thesis concludes with evaluation of the resulting system and outlining the future development options.
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Performance Appraisal as a Human Resource Management Tool in the Field of Agriculture
Venclová, Kateřina ; Macák, Tomáš (advisor) ; Fejfarová, Martina (referee)
Purpose: The aim of this PhD dissertation is to design a performance appraisal system as
a Human Resource Management (HRM) tool for selected professions in the field of agriculture in the Czech Republic. Further objectives of the dissertation are to identify the significance of HRM and performance appraisal in the field of agriculture within generational change. A subsequent objective is to create a theoretical performance appraisal system for selected professions as a tool of HRM. Further objectives are to determine the current state of formal performance appraisal and to identify the input criteria of an appropriate performance appraisal system for the field of agriculture.
Research design/methodology/approach: The research for this dissertation has been developed on the basis of a mixed methods research design, involving a sequential strategy based on quantitative and qualitative research methods. Moreover a pragmatic philosophical approach has been adopted. The quantitative and qualitative elements of the strategy adopted include study of pertinent literature, an electronic questionnaire, personal interviewing, one--dimensional and multidimensional statistical methods.
Findings: A performance appraisal system for selected professions as a tool of HRM in the field of agriculture in the Czech Republic has been designed, together with possible areas for future research. The survey conducted has shown over a period of 3 years that the majority of agricultural organizations do not utilise any performance appraisal system. However, this research demonstrated the significance of a performance appraisal system in the context of the selected HRM model within generational change in the field of agriculture. The research also explored the currently used performance appraisal methods, identified appraisers and appraisees, the purposes of performance appraisal in the field of agriculture, and performance appraisal connection to the reward system.
Research limitations: The random sample of agricultural organizations was not necessarily representative of the industry as a whole, because the sample taken was a purposive sample. The length and structure of the questionnaire developed for this research was not sufficient to permit the detailed identification of performance appraisal methods used and the criteria applied in the field of agriculture. In order to compensate for this limitation, personal interviewing with a random sample of informants was conducted.
Originality/value: No previous research focused on performance appraisal in the field of agriculture has been conducted in the Czech Republic. The research described in this dissertation presents the first detailed description and analysis of the currently used performance appraisal system for the field of agriculture in the Czech Republic. The Author recommends that the currently used performance appraisal system should be used to extend other performance appraisal methods focused in the areas of process and input to reach higher attitude of HRM. In addition, the author highlights the importance of performance appraisal outputs in the connection to the reward system. The specific performance appraisal system proposed here may be beneficial for good management during a period of generational change. Furthermore, it may support more effective human resource management in the field of agriculture. It is hoped that this PhD dissertation may provide the basic groundwork for further research in other HRM areas and performance management.
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System approach and simulation of business processes in the chosen restaurant
Taraskina, Anastasiya ; Krejčí, Igor (advisor) ; Horáková, Tereza (referee)
The bachelor thesis is concentrating on application of system dynamics in the real restaurant, to be more specific on ordering system of vegetables to minimize its throwing out. In theoretic part there is mentioned the history of system dynamics, its many applications in the world and in the Czech Republic. Next there are explained important terms that are connected to system dynamics. There is mentioned the relation between system dynamics and system thinking. Also there are tools used to describe structure of the system and the most recent system's archetypes. The practical part describes the restaurant and there are set goals that the model is trying to achieve. There are described two diagrams, one is causal loop diagram and the other is stock and flow diagram. Thanks to these diagrams it was possible to receive optimization for needed data and to achieve set goals.
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