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The role of genetic factors in the prognosis and prediction of effects of the chemotherapy of breast carcinoma
Hlaváč, Viktor ; Souček, Pavel (advisor) ; Hodek, Petr (referee) ; Liška, Václav (referee)
Breast carcinoma is the most common cancer among women in our country and worldwide. One of the obstacles to successful therapy is a multidrug resistance. It can be caused by different factors, such as overexpression of ABC transporters, or decreased expression of SLC transporters, deregulation of drug metabolizing enzymes, variability of the targets of anticancer drugs, failure of apoptosis or increased capacity of repair genes. The aim of this study was to search for associations of genes of drug transport and metabolism with the prognosis of patients or response to chemotherapy. From the view of preventive medicine, this aim constitutes an important part of both secondary and tertiary prevention of cancer, i.e., discovery of markers enabling optimal therapy selection for each patient, decreasing the risk of disease progression to advanced and resistant stage, and elimination of side effects of chemotherapy. The expression profile of ATP-binding cassette (ABC) transporters (49 genes), cytochromes P450 (CYPs, 10 genes), aldo-keto reductases (AKRs, 13 genes) and carbonyl reductase 1 was analyzed in the tumor and adjacent non- tumor control tissues in a cohort of neoadjuvantly treated patients. Genes deregulated in tumors compared with control tissues or genes associated with clinical data were assessed in...
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Analysis of the active employment policy in the Czech Republic and the Federal Republic of Germany
Hlaváč, Vlastislav ; Kotrusová, Miriam (advisor) ; Kotíková, Jaromíra (referee)
Résumé This thesis focuses on the implementation of the active employment policy in the Czech Republic and the Federal Republic of Germany and in particular its use of a time when the labour market is negatively affected by the effects of the economic recession. Financial support provided to employers to create or maintain jobs proved to be crucial, confirming the model used in the Federal Republic of Germany. The analysis of tre nds in the labour market shows increasing importance of implementing active employment policy, which both lead to job creation, but the activation of unemployed persons. The findings of this thesis stems can be applied throughout the Czech Republic. Some m easures to increase employment can be implemented without significant interference, in a change in methodology, but some must be implemented on the basis of political acceptability.
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People tracking in sparse crowd using multiple cameras
Zimmermann, Jan ; Suk, Tomáš (referee) ; Hlaváč, Václav (advisor)
In this thesis, we introduce a new algorithm for tracking of multiple people in image sequences from surveillance cameras. The algorithm handle with trustworthiness in similarity measure of human gures in images. All decisions are made as trustworthily as possible. The algorithm nds out the number of people in the scene autonomously. It deals with potential temporary occlusions of people in image. The tracking algorithm does not suffer from the problem of human model initialization as some other methods do. The implementation of our algorithm is a part of this thesis. This implementation has veri ed the characteristics of the algorithm. We have used two different methods for the image segmentation. Both method prove successful in different conditions. We have used a color information to compare the visual similarity. Suitable future extensions are suggested at the end of this thesis.
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Online and Offline Vocabulary Correction while using a Digital Pen
Shrestha, Prajol ; Hlaváč, Václav (advisor) ; Průša, Daniel (referee)
This thesis is a requirement for the completion of my double degree with Charles University and University of Nancy (France) under the Erasmus Mundus masters program in Language and Communication Technology. The topic was provided by Prof. Abdel BelaÄd along with Actimage Company and has been completed and successfully defended at University of Nancy under their supervision. After the defense in France, I came here to Prague and worked with my co-supervisor Dr. Václav Hlaváč to improve the text of the thesis to meet the standards of Charles University in order to defend it in Prague. The aim of this work is to study some helpful handwriting correction marks and propose a system that automatically incorporates the corrections made by the writer while writing with a digital pen. The problem is complex because the corrections have to be at the same time readable by the writer and by the machine. Even detecting a free řowing line of handwritten text has not been understood completely by machines. The spatial relations between the correction marks and the text line are easily detected by the writers and readers and hence systematic to them, yet for machines this detection is a huge challenge. Humans have an intelligence that is hard to mimic by machines. This seemingly systematic writing has not been studied in...
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Unsupervised learning based on images
Krupička, Radim ; Forst, Libor (referee) ; Hlaváč, Václav (advisor)
The aim of the project was to create an experimental environment for solving the children puzzle shape sorter . This environment serve as a testbed for various learning tasks of cognitive nature with image feedback. This puzzle is a demonstrator of the EU project COSPAL, IST-004176. The industrial robot CRS A-465 with six degrees of freedom and its control system is used. The scene is observed by one static camera. The system processes the images from the camera and the further robot movement is based on the reinforcement learning.
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Control of the industrial robot with cameras
Janda, Pavel ; Obdržálek, David (referee) ; Hlaváč, Václav (advisor)
This thesis belongs to the implementation category of diploma theses. The work contributes to the EC project COSPAL, IST-2003-004176. The main goal of the project was the creation of the system of control and processing of the camera information for the assembly task. The demonstrator is used within the scope of the COSPAL project to solve a child's game - shape sorter puzzle. For solving the puzzle, the industrial robot CRS Robotics A465 was used. The robot has been available at the supervisor's place.
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Methodology to assesment the amount of compensation of otter damages
Poledníková, K. ; Poledník, L. ; Hlaváč, V. ; Maštera, J. ; Mináriková, T. ; Rešl, D. ; Tomášková, L. ; Šíma, J. ; Toman, A. ; Pacovská, M. ; Kameníková, M. ; Beňová, M. ; Kratochvílová, M. ; Beran, V. ; Kadlečíková, Z. ; Růžičková, O. ; Hájková, Petra
Methodology for determining the amount of compensation of damages caused by Eurasian otter describes exact procedure to evaluate this damages, including calculation examples, and sets procedures for experts compiling the report on how to proceed in field examination. Methodology is possible to use for expert reports by course of Law No. 115/2000.
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