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Hardware and software of a smart home appliance
Blaha, Vít ; Kaczmarczyk, Václav (referee) ; Fiedler, Petr (advisor)
Nowadays, the interest in smart appliances, which enable consumption reduction or consumption shifting approach, grows up. Such appliances can react to actual situation in the distributional network. From the energy distributor point of view, the activity of these appliances brings improvement of stability in the distribution network, while for the end customer there is possibility of the saving money. This thesis describes a transformation of standard fridge to smart fridge controlled by microcomputer Raspberry Pi. The smart fridge can communicate with supervisor system and according to its instructions change its behavior (temperature set point). The appliance can be manually controlled by a group of buttons, while its state can be visualized on the alphanumeric display. Last but not least way to control the appliance is through a web interface. The thesis also describes design of printed circuit board (PCB), which is designed for connection of all necessary sensors and actuators to Raspberry Pi. Software equipment is designed in the C++ program language.
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Mathematical model of nanobrewery
Blaha, Vít ; Baránek, Radek (referee) ; Kopečný, Lukáš (advisor)
The thesis describes a mathematical-physical model of nanobrewery designed in program Matlab-Simulink. It is focused on warming of fluid in a container with printed heating spirals and in a container with oil bath. Formed models are verified with real systems. Based on this comparison, unknown parameters' values of designed models are found out. These values are further used for s imulation of fluid temperature time- dependency in measured nanobreweries during mashing. Both types of warming are compared in the final part of the thesis.
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Genetic factors of familial hyperlipidemia and prevention of cardiovascular diseases
Todorovová, Veronika ; Češka, Richard (advisor) ; Blaha, Vladimír (referee) ; Karásek, David (referee)
Familial hyperlipidemias are still a current cause of premature development of atherosclerotic cardiovascular disease (ASCVD). Heredity plays an important role in the development of these diseases. Genetic testing helps to specify a definite variant of a given disease and thus the degree of genetic family burden. Together with the clinical examination, it defines the exact diagnosis of the patient and reduces the risk of developing ASCVD in individual specialized care. In the theses, we focused on biochemical and genetic differences and their risk factors for the development of ASCVD in long-term monitored patients with familial hypercholesterolemia (FH), in receptor-mediated FH and familial defect of apolipoprotein B- 100 (FDB). Efficacy, safety, and tolerability of therapy were evaluated in a subgroup of FH patients with PCSK9i therapy. Furthermore, the polygenic genetic risk score (GRS) in patients with the APOE2E2 genotype and its influence on the early detection of the development of familial dysbetalipoproteinemia (FD) were analyzed. Receptor-mediated FH patients carry a mutation in LDLR while FDB patients have a prevalent mutation in APOB. LDL-C and TC levels are high in both groups, although levels are slightly higher in receptor-mediated FH patients. APOE genotype and risk factors such as...
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Rotation-invariant pattern matching for egg recognition
Bláha, Vojtěch ; Vomlelová, Marta (advisor) ; Harmanec, Adam (referee)
This bachelor's thesis follows up the recognition of eggs in the image. The goal was to create a group of programs that firstly captures image data, than finds eggs in them and finally shows the results in some user environment. We tested gradually different classification methods (template matching, logistic regression and neural network). We tried also different representations of the image such as matrix representation and ring projection, and various pre-processing of the image before the actual finding, we used grayscale, color spectra and edges detected by a high-pass or Kirsche detector. After testing all methods, we selected the best one and created the classification program itself. The most successful method was logistic regression with ring projection. 1
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Non-existence as a new institution of Czech law
Bláha, Václav ; Zvára, Michael (referee)
Non-existence as a new institution of Czech law Abstract The aim of the thesis is to examine the institute of non-existence which is new in the Czech law. Therefore, the beginning of the thesis is arranged in order to make clear the chronological development of civil law in terms of wrongful conduct and/or wrongful legal act sanctions. Historically, the General Civil Code (ABGB) is of particular relevance. ABGB was an important civil code not only on our territory but also in Austria and other countries of the former Habsburg Monarchy. While the original text of this Code sanctioned wrongful legal acts by invalidity ("Ungültigkeit"), the 1916 amendment introduced another term into the Code, taken from the German Civil Code (BGB), and namely "Nichtigkeit". Although this term means "invalidity" as well, it was mistakenly translated into Czech by the word "nicotnost" (literally "nothingness" in English). In the thesis, the legal situation in the period from 1948 till 2014 is discussed briefly, mentioning in particular the Family Act which, commencing from 1998, included, in addition to the term "invalidity" (of marriage), also the term "non-existence" (of marriage) stating that no marriage is formed in these cases. The following part of the thesis deals with the applicable law. The problems of legal act, its...
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Tissue and soluble endoglin relation to the endothelial dysfunction and possible treatment
Blažíčková, Kateřina ; Nachtigal, Petr (advisor) ; Blaha, Vladimír (referee) ; Mičuda, Stanislav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Msc. Katerina Blazickova Supervisor: Assoc. Prof. PharmDr. Petr Nachtigal, Ph.D. Title of Doctoral Thesis: Tissue and soluble endoglin relation to the endothelial dysfunction and possible treatment Atherosclerosis is a complex inflammatory disease and it represents a major source of morbidity and mortality in the world as a part of cardiovascular diseases. Endothelial dysfunction represents the first step in the development of atherosclerosis and it is characterized by disruption of endothelial homeostasis. Statins are drugs of choice in the treatment of atherosclerosis and they can decrease LDL cholesterol levels and positively affect levels of HDL cholesterol. Statins, however have a wide range of other effects, which are referred to non-lipid or pleotropic effects. The most important non-lipid effects of statins are lipid- independent modulation of endothelial function, antioxidant, anti-inflammatory, antithrombogenic and antiproliferative effects. The most widely used animal model for the study of atherosclerosis is the mouse model. Thanks to a high fat diet and genetic modification, we are able to modify lipid profile in mice and induce atherosclerotic changes even at...
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Significance of Assessment of Glycemic Index of Foods in the Treatment of Insulin Resistance Syndrome
Víšek, Jakub ; Rušavý, Zdeněk (advisor) ; Rosolová, Hana (referee) ; Blaha, Vladimír (referee) ; Prázný, Martin (referee)
OBJECTIVE - The aim of this study was to compare the impact effectiveness of a diet with a low glycemic index versus a common diabetic diet in selected metabolic and anthropometric parameters. RESEARCH DESIGN AND METHODS - 20 volunteers with the type 2 diabetes treated only with metformin were randomly split into two groups. Each group was advised to follow a common diabetic diet (DD) or a diet with a low glycemic index (GI) for a period of 3 months in a crossover design. The effectiveness of the two diets was evaluated according to the selected metabolic and anthropometric parameters using a hyperinsulinemic euglycemic clamp with endogenous glucose production measurement, indirect calorimetry and bioimpedance analysis. RESULTS - Body weight after 3 months following DD was 93kg (83-104) vs. GI 92kg (85- 104) p<0.05, BMI DD 31.3 kg/m2 (27.5-35.9) vs. GI 30.7 kg/m2 (27-35.3) p<0.05, body fat DD 28% (25.5-43) vs. GI 27% (23-43) p<0.05. The diets did not differ in effects on glycosylated hemoglobin, fasting glucose, lipid profile, insulin sensitivity or hepatic glucose production. CONCLUSIONS - In comparison with a common diabetic diet, the diet with low GI leads to a slight weight loss, as well as the BMI and body fat reduction. No significant differences regarding glycemic control, lipid profile, insulin...
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Lipoprotein-associated Phospholipase A2 in Geriatric Diabetic Patients
Fortunato, Joao ; Blaha, Vladimír (advisor) ; Nachtigal, Petr (referee) ; Soška, Vladimír (referee)
v anglickém jazyce Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an extracellular Ca2+- independent 45 KDa secreted enzyme formed by 441 amino acids. It circulates in plasma in the active form and is encoded in the PLA2G7 gene located on chromosome 6p12-21.1. Lp-PLA2 hydrolyzes several types of short-chain and oxidized phospholipids that harbor acyl groups at the second position of the glycerol backbone. It is mostly bound to low density liproprotein (LDL) particles and it is thought to play a role in the development of cardiovascular diseases (CVDs). Indeed, multiple studies propose that elevated mass concentration and/or activity of Lp-PLA2 is an independent risk factor for the development or recurrence of CVDs. We performed a cross-sectional analysis on 44 geriatric patients aged 79.6 ± 5.6 years that had undergone transcatheter aortic valve implantation (TAVI) or ballon valvuloplasty (BV) for the treatment of severe aortic stenosis. Lp-PLA2 mass concentration was already increased in elderly patients before TAVI or BV and significantly increased after the procedures. We found strong correlations with LDL concentration (LDL-C), total cholesterol and triglycerides. Baseline Lp-PLA2 mass concentration was increased in diabetic patients comparing to non-diabetic patients. We then discuss and...
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