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The Role of the Tumour Microenvironment on Melanoma Cell Invasiveness
Jobe, Njainday ; Rösel, Daniel (advisor) ; Kořínek, Vladimír (referee) ; Bušek, Petr (referee)
Cancer cell invasion and metastasis are hallmarks of cancer. It is becoming apparent that the interaction between cancer cells and the surrounding microenvironment are involved in their ability to invade and metastasise. In general, cancer cells can either migrate individually, in an amoeboid or mesenchymal manner, or collectively. The first aim of this thesis was to analyse the role of NG2 in amoeboid to mesenchymal transition (AMT) and Rho/ROCK signalling. We found that NG2 promotes an amoeboid morphology, and increased invasiveness, in a Rho-dependent manner. Secondly, we analysed the role of the major tumour microenvironment (TME) component, cancer-associated fibroblasts (CAFs), on melanoma cell invasiveness. We found the CAF interaction with melanoma cells leads to increased levels of interleukin-6 (IL-6) and IL-8, and this leads to increased invasiveness. Simultaneous blocking of IL-6 and IL-8, using neutralising antibodies, inhibits CAF-dependent invasion. Further analysis of another major component in the melanoma TME, keratinocytes, has highlighted the importance of the tumour cell niche in invasion. Our results indicate that cancer cells have the ability to change morphology, and that the TME plays an important role in melanoma cell invasiveness. Metastatic melanoma treatment has proven...
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The Proposal of Company Marketing Mix
Kovářová, Vlaďka ; Přikrylová, Renáta (referee) ; Novák, Petr (advisor)
This bachetor thesis is focused on the marketing mix of the company STAVING Olomouc,l.t.d. The theoretical head of the thesis contains both the starting point of the marketing mix and the decription of its particular parts. The analytical head of the thesis contains the analysis of the marketing mix of the company and the marketing analysis. The proposal head conains proposals for improvement.
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Analysis of the microenvironment companies
KOUDELKOVÁ, Kateřina
The main purpose of bachelor "Analysis of the microenvironment companies" is determine the position of the company Pivovar Protivin, on the Czech market with the help of Porter's five forces model and evaluate the economic and financial situation with the help of selected indicators.
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Company Marketing Strategy
Macková, Monika ; Přikryl, Pavel (referee) ; Schüller, David (advisor)
The bachelor’s thesis focuses on the marketing strategy for Confectionery, café U Anděla, which is situated in Strážnice. In the introductory chapter of the theoretical part, several terms related to marketing are defined. In the second part, I analysed the current situation in the confectionery and carried out research into the expectations of customers by using a questionnaire. From the results, I suggested improvements in the sectors that turned out to be insufficient.
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Proposal of Marketing Mix
Mančíková, Jana ; Bačíková, Hana (referee) ; Novák, Petr (advisor)
The bachelor thesis focuses on analysis of marketing mix of the shop which applies to a sphere of local farm and healthy food. The thesis consists of theoretical terminology and proposals in order to improve the current situation which follows from the research of the current issues.
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Marketing Strategy of the Nano Snowboards Brand
Vintrová, Zuzana ; Asfourová, Nataly (referee) ; Chlebovský, Vít (advisor)
The Master’s thesis deals with the proposal of marketing strategy. Based on theoretical knowledge and analysis of contemporary conditions of the company, proposal of marketing strategy is developed. It is supposed to distinguish company position beside other companies and to get awareness of public. This leads to gaining new clients and as a result of achieving higher sales and profits.
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