National Repository of Grey Literature 345 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Tumor infiltrating lymphocytes as prognostic factor in colorectal cancer prognosis after radical surgical treatment
Novák, Petr ; Vodička, Josef (advisor) ; Šiller, Jiří (referee) ; Gürlich, Robert (referee)
Novák P.: Tumor infiltrating lymphocytes as prognostic factor of colorectal cancer after radical surgical treatment Background: Colorectal cancer (CRC) belongs among the most frequent malignant diseases and represents worldwide problem. Czech Republic has one of the highest incidence of CRC. The fight against this disease is kept in many lines as preventive, surgical and oncological treatment and very important part is also the estimation of prognosis and suggestion of individual treatment. Aim: The aim of this study was to analyze the relation of contemporary clinical and histopathological factors and tumor infiltrating lymphocytes, dendritic and natural killer cells. The next aim was to differentiate the patients with high risk of shortened overal survival and tendency to early recurrence of CRC after radical surgical treatment. Methods: We analyzed the group of 150 patients (93 men, 57 women) that were operated on at the Department of Surgery of Teaching Hospital in Pilsen between 2004 and 2007. The important condition for inclusion into the study was radical operation. We excluded patients with any disease that could influence immunological reactivity. We examined endovascular, endolymphatic, perineural infiltration by tumor cells (0 - none, 1 positive). Infiltrations of tumor by lymphatic cells...
Planetary Gearboxes in Both Passenger Cars and Trucks Construction
Novák, Petr ; Řehák, Kamil (referee) ; Prokop, Aleš (advisor)
The thesis deals with the use of planetary gears in automatic transmissions for cars and trucks. The transmission part consists of Simpson and Ravigneaux gears. Therefore, their kinematic analysis is performed here. A complete description of the automatic gearbox explains in detail the principle of the function of the gearbox as a whole. Furthermore, the work is divided into two parts - gearboxes for cars and trucks. A research is carried out, the main characteristics of the group are described and their representative is discussed in detail. In the last part the kinematic and force analysis of ZF - Ecomat 6HP 602 gearbox is carried out.
Addictological causes of declaration of nullity of marriage in contemporary canon law of the Roman Catholic Church
Novák, Petr ; Čačík, Marián (advisor) ; Hrdina, Antonín (referee)
Addictological causes of declaration of nullity of marriage in contemporary canon law of the Roman Catholic Church Abstract This thesis presents in detail the addictological causes of marriage nullity in canon law of the Roman Catholic Church. According to the Canon Law (Codex iuris canonici, 1983) a marriage may be declared null because of psychological inability under certain conditions. The addiction (and addictive behavior) is one of the most serious mental illnesses. Pope Francis pointed out the addiction as a "new form of slavery" and a "wound in our society" which should be combated with education and rehabilitation. In many cases the legal proceedings are very difficult and the canonical lawyers need the expert report from the field of addictology, psychology and psychiatry. The aim of this thesis is to give the essential addictological and psychological knowledge connected with the regulations listed in canon 1095 of the actual canonlaw code.
Virulence of Bordetella pertussis from an Omics Perspective
Novák, Jakub ; Šebo, Peter (advisor) ; Černý, Jan (referee) ; Novák, Petr (referee)
The Gram-negative aerobic coccobacillus Bordetella pertussis is one of the few exclusively human pathogens and the main causative agent of the respiratory infectious disease called pertussis, or whooping cough. Despite global vaccination programs, pertussis remains an important public-health burden and still accounts for over 100,000 infant deaths and over a dozen of millions of whooping cough cases every year. Substantial effort is devoted to studies on the mechanisms of action of virulence factors of B. pertussis, but the biology of interactions of B. pertussis with its human host remains largely underexplored. Evolution, genetics and adaptation of B. pertussis to the complex environment of human nasopharynx and the mechanisms enabling B. pertussis to overcome host innate and adaptive mucosal immune defenses, remain poorly understood. In such situations, unbiased exploratory omics approaches represent valuable tools for uncovering of unknown aspects of host-pathogen interactions and open the path to detailed analysis of virulence-underlying processes by mechanistic studies. In this thesis, I am presenting the results of three omics projects on B. pertussis biology that involved high-throughput proteomics. In the inital phosphoprotemics project, we analyzed the kinase signaling pathways hijacked...
Intra-individual stability of performance and level of kinesthetic-differentiation ability in wedge play in golf players of varying performance level
Novák, Petr ; Gryc, Tomáš (advisor) ; Carboch, Jan (referee)
Title: Intraindividual stability of performance and kinestetic abilities level in wedge play performed on golf players with different performance level Goal: Goal of this thesis is detect an intraindividual stability of full swing performance in wedge play and find out kinestetic abilities level of golf players with different performance level when they control distance of ball flight, club head speed and ball speed. Methods: There were 15 golfers participating in this study (n = 15). Tested subjects are characteristic by these values: age 18,36 ± 2,61, body height 180,86 ± 7,38, body weight 73,21 ± 10,25, HCP HCP -0,47 ± 1,53. Intraindividual stability of performance and kinestetic abilities level was tested by instrument TrackMan. Gained values were processed by statistical methods in Excel. Pearson coeficient was used to find out the dependence between data. Results: We found high level of intraindividual stability from test results. Significant difference was found between in distance, club head speed and ball speed parameters with and without feedback. Significant connetion between intaindividual stability and performance parameters was found only in 1/3 of cases, same as connection between kinethetic ability and performance parameters. Key words: Short game, golf swing, approach shots, abilities
Protein radical footprinting as a tool for protein therapeutcs validation.
Binar, Michal ; Novák, Petr (advisor) ; Ječmen, Tomáš (referee)
Mass spectrometry techniques are very important and useful tool in studying of protein structure. One of these techniques is the covalent labeling of proteins. The covalent labeling can be used for determination of the accessibility of protein surface and their dynamics in general. Although a lot of reagents have already been developer for this method, most of them are limited by their ability to selectively react with only some of amino acids, mostly lysine, arginine or tyrosine, and non-selective methods such as fast photochemical oxidation of proteins are very demanding and costly. Therefore, there is still a endeavor to develop new methods of covalent labeling. This new method could be trifluoromethylation, which is increasingly used in the modification of organic molecules, and whose potential we have decided to study. In this work we used a new group of formally electrophilic agents, which is formed on the basis of a cyclic hypervalent iodide nucleus. This group so-called Togni reagents was used as a tool for radical protein labeling. Since the structure was well characterized by X-ray, NMR and MS, the human carbonic anhydrase has been selected as a model protein. The modified protein was analyzed by a bottom up approach using a combination of liquid chromatography and high resolution tandem...
Increasing security awareness in the company
Novák, Petr ; Sedlák, Petr (referee) ; Ondrák, Viktor (advisor)
The master’s thesis is focused on increasing security awareness in the company. The first chapter contains the theoretical background, which is necessary for creating a security education system. The second chapter deals with the analysis of the current situation, which is needed for determinating the need to increase security awareness. The third and last chapter contains the design of the education system itself.
Apartment building Slatinska
Novák, Petr ; Jelínková, Barbora (referee) ; Jelínek, Petr (advisor)
This bachelor's thesis deals with the design of the building in the Brno-Židenice and with the processing of project documentation for the construction. The building is divided into two main parts - residential part and administrative part, which consist of a smaller office on the ground floor. Every part has own entrance from the street Slatinská. Parking is provided outside the building on the plots and has 9 parking spaces. The building has 3 floors, no basement and is built below the White Mountain. The shape of the building is rectangular with several protruding and receding parts of rectangular shape. In the residential part of the basement there is a background of an apartment building and in the upper floor there are 5 residential units of various sizes and layouts. The basis of the building is solved with the help of drilled piles in combination with the base plate. The construction system of the building is designed from masonry ceramic blocks. Ceiling structures, lined and receding structures are made of reinforced concrete. The roofing of the building is solved by an extensive green roof. The whole building is a contact insulated certified by the ETICS insulation system consisting of insulating polystyrene foam.
Use of laser machines for metal cutting technology
Novák, Petr ; Osička, Karel (referee) ; Kalivoda, Milan (advisor)
This bachelor thesis deals with laser cutting technology and its use in industry. A large part of the work consists of theoretical research, dealing with the characteristics of individual types of laser machines and their use for industrial applications, especially for metal cutting. Furthermore, the work is focused on the theory of this technology and suitable materials. The work also deals with two companies, which represent typical use of a laser machine. In the experimental part of this thesis the manufacturing process of component is created based on a survey of the use of laser machines.

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