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De-identification of speakers with hypokinetic dysarthria
Kárník, Radoslav ; Kiska, Tomáš (referee) ; Mekyska, Jiří (advisor)
This paper discuses design and implementation of a system that performs de-identification of speech recordings of patients suffering from Parkinson's disease. The paper describes causes and symptoms of Parkinson's disease and effects of hypokinetic dysarthria on speech. Part of the paper is devoted to speech features that can be used for diagnosing hypokinetic dysarthria from speech. It also describes ways of speech de-identification and system for evaluating results using recognition of speakers and patients. De-identification system uses vocal tract length normalization (VTLN) and evaluating system uses Gaussian mixture models (GMM). PARCZ database was used for testing. It contains recordings of speech of patients affected by Parkinson's disease and control speakers.
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Acoustic analysis of gender-related patterns in Parkinson's disease
Herinek, Denis ; Kiska, Tomáš (referee) ; Galáž, Zoltán (advisor)
The bachelor's thesis is about acoustic analysis of gender-related patterns in Parkinson's disease by analysing speech task: reading passage. Parkinson's disease manifests in all subsystems involved in speech production (respiration, phonation, articulation and prosody). The aim of this thesis is familirization with symptoms of this disorder and speech parameters influenced by this disorder. Thesis contains preprocessing, parametrization of speech signal and statistic analysis of parameters. System of speech signal processing is created in MATLAB programming language.
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Effects of gluten-free diet on immune parameters in Parkinson's disease
Jandová, Mônica ; Funda, David (advisor) ; Dobeš, Jan (referee)
Tato studie zkoumá možné, i malé, vlivy bezlepkové diety v porovnání se standardní dietou na rozvoj Parkinsonovi nemoci s využitím 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinem (MPTP) indukovaném myším modelu Parkinsonovi nemoci, a samců kmene C57Bl6. Tento výzkum zahrnuje zavedení jak akutního tak chronického myšího MPTP modelu, a řadu navazujících flow cytometrických analýz zaměřených na regulační T buňky, cytokiny - interleukin 10 (IL-10) a interferon gama (IFN-), gamma/delta T buňky, a NK buňky ve slizničních a sytémových lyfatických orgánech. Pro posouzení vlivu na chování jse použili test otevřeného pole, který nám umožnil posoudit lokomotorickou aktivitu a explorativní chování myší v závislosti na podávané dietě. Dále jsem použili také imunofluorescenční barveni pro validaci efektu MPTP, které nám poskytlo vizuální potvrzeni neuroanatomických změn indukovaných neurotoxinem. První výsledky naznačují malé ale slibné známky pozitivních efektů bezlepkové diety. Nicméně tyto změny lze pouze opatrně interpretovat, protože je potřeba opakovaných a podrobnějších experimentů k posouzení zazanmenaných efektů. Spojení behaviorálních testů, imunohistologie a imunologických analýz představuje vícečetný metodicky přístup k této problematice, který nám může poodhalit komplexní interakce diety, střeva,...
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Aerobic training in the treatment of gait disorders in patients with Parkinson's disease
KOCÁBKOVÁ, Štěpánka
This bachelor thesis investigates the effect of aerobic training on gait disorders in patients with Parkinson's disease. The specific features of gait in this disease are short, shuffling steps, slowed movement, impaired balance and reduced upper limb synkinesis. All of these features can, apart from the application of medication, be influenced to some extent by regular exercise. The aim of this bachelor thesis was to design a suitable exercise unit for these patients and to describe the effect of aerobic training on gait disorders. The theoretical part is an introduction to the issue of Parkinson's disease. Subchapters describe the definition, incidence, research history, anatomy and physiology of the basal ganglia, etiology, clinical features, stages, diagnosis and treatment. Furthermore, there is compared gait analysis of Parkinson's disease patients with healthy individuals and what the term aerobic training means. The practical part is processed in the form of qualitative research. Based on the input examination of three patients diagnosed with Parkinson's disease, I created an exercise unit, which can be found in Appendix 3. After three months, I did an output examination and compared if the created exercise unit had a positive effect in gait disorders or not. From the results, the positive effect of aerobic training on gait disorder in Parkinson's disease patients could not be clearly demonstrated. For a valid result, research would need a larger number of patients. However, patients evaluated the exercise unit positively and I believe that this work could find further application, for example in the clinical practice of physiotherapists or as an educational material for patients with Parkinson's disease and their family members.
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Evaluation of therapeutic treatment effect by gait analysis in patients with Parkinson's disease
Dvořáková, Kateřina ; Lopot, František (advisor) ; Nováková, Tereza (referee)
Title: Evaluation of therapeutic treatment effect by gait analysis in patients with Parkinson's disease Objectives: The aim of the presented diploma thesis is to expand the Parkinson's disease (PD) information base and contribute to the elimination of existing contraindications. Specifically, the thesis is focused on researching the gate of patients with PD, as one of the subjectively most distressing symptoms of this disease. Methods: 8 probands with Parkinson's disease aged 62-76 years participated in the research. Anamnestic questionnaires specialized in the diagnosis of PD were used to obtain basic information about the probands. Gait itself was tested using 3D kinematic analysis by the Qualisys device, and also by standardized physiotherapy tests indicated in the guidelines of physiotherapy for PD. Dual-task training, which was applied for six weeks, was chosen as the therapy method. A comparative t-test was used to evaluate statistically significant changes during walking after the therapeutic intervention. Results: By evaluating the data using statistical tests and direct observation, a positive effect of the therapeutic intervention using dual-task training on the walking of patients with PN was found. Statistically significant changes in measurements using the Qualisys motion capture...
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Multidisciplinary team and care of patients with Parkinson's disease
Svobodová, Martina ; Vrzáček, Petr (advisor) ; Lejsal, Matěj (referee)
The aim of the thesis is to map the needs of social service clients with Parkinson's disease. Based on the needs, the goal of the work is to design a multidisciplinary team, its composition and functioning. In the theoretical part, I deal with Parkinson's disease as such, diagnosis, course, treatment and its side effects. I am also involved in social services, especially those that specifically focus on clients with Parkinson's. This part concludes with chapters on participation and empowerment, patient organizations and the multidisciplinary team as such. The third part deals with the methodology of the research. I used combined research, specifically interviews, field research and a questionnaire. I describe here the data analysis and ethical aspects of the research. The results of the research show that a multidisciplinary team is a suitable variant of care to fulfill some of the clients' needs. Here, I observe where the view of the client himself and the caregivers on the client's needs differ from each other and where they are in harmony. Based on the research, I subsequently propose the composition of a multidisciplinary team and model its functioning. In the discussion, I try to look critically at my work and also to confront it with other works that focus on a similar topic. The conclusion...
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Use of dance therapy in neurorehabilitation from the perspective of a physiotherapist
Tlustá, Tereza ; Gueye, Tereza (advisor) ; Sládková, Petra (referee)
First and last name: Tereza Tlustá Supervisor: MUDr. Bc.Tereza Gueye Ph.D. Opponent of the thesis: Name of the thesis: Use of dance therapy in neurorehabilitation from the perspective of a physiotherapist. Abstract of the thesis: The bachelor's thesis summarises the present level of knowledge and evidence on the impact of dance therapy on motor symptoms of neurological disorders through a systematic review. The theoretical part provides a comprehensive overview of dance and dance movement therapy and their impact on the musculoskeletal and nervous system. A part of the thesis is also focused on the characteristics and scope of physical rehabilitation of neurological patients and the characteristics of symptoms of some neurological diseases, namely Parkinson's disease and stroke. In the second phase, by analyzing the studies obtained by literature search, fifteen recent and relevant articles were included and analyzed. Through analytical analysis of the results of testing and evaluation of each study, it is determined whether and under what conditions dance therapy was effective. The presented articles include studies testing the effect of dance therapy on stability and gait in Parkinson's disease and post-stroke patients. The paper presents a mostly positive conclusion about the effect of dance...
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Development of features quantifying respiratory dysfunctions in Parkinson’s disease patients
Cvetler, Dominik ; Mekyska, Jiří (referee) ; Kováč, Daniel (advisor)
In the beginning of the thesis, Parkinson's disease and hypokinetic dysarthria are briefly described, which have a negative effect on speech production and cause breathing problems during speech in sick patients. The aim of the thesis is to create an algorithm for automated detection of breaths and the design of parameters for the quantification of respiratory disorders in patients with Parkinson's disease. In the MATLAB environment, the recordings of the researched subjects were processed and an algorithm was created for the detection of breaths, which used the logistic regression method. Based on the predicted breaths, proposed parameters were extracted from the recordings, which were then statistically analyzed and compared in healthy controls and patients with Parkinson's disease. By using a machine learning model, it was possible to predict the clinical data of patients from the proposed parameters to a certain extent. The average accuracy of the model for predicting puffs was 0.85. Of the 14 proposed parameters, 6 were suitable for quantifying respiratory disorders associated with hypokinetic dysarthria. The result of the work is a functional algorithm for the automated detection of breaths in the speech signal and proposed parameters that could be useful for the quantification of respiratory disorders in patients with Parkinson's disease.
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Sub-types of hypokinetic dysarthria in patients with moderete Parkinson's disease
Adamják, Adam ; Kováč, Daniel (referee) ; Mekyska, Jiří (advisor)
This final thesis deals with the research of Parkinson's disease, hypokinetic dysarthria, and acoustic and statistical analyses. Hypokinetic dysarthria is a speech disorder that is a typical manifestation of Parkinson's disease, a neurodegenerative disease that affects approximately 2% of the population over the age of 65. The aim of this work is to reveal the subtypes of hypokinetic dysarthria, based on clinical parameters, acoustic analysis, and statistical analysis. In the acoustic analysis, parameters that examine the area of phonation, prosody, articulation, and speech tempo have been implemented. Subsequently, a statistical analysis was processed, thanks to which it was possible to reveal the subtypes of hypokinetic dysarthria.
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Remote Parkinson's disease monitoring system
Podlužanský, Pavel ; Galáž, Zoltán (referee) ; Mekyska, Jiří (advisor)
Parkinson's disease is an incurable disease, but with appropriate monitoring, the condition of patients can be significantly improved. The thesis deals with the creation of a system for monitoring Parkinson's disease. The system can save both neurologists and patients valuable time, and at the same time, it can allow neurologists to take care of more patients. The system is implemented, secured and tested as designed. The system can reliably evaluate the results of examinations from patients and send them to neurologists. Individual examinations belong to different categories. Patients are monitored based on movement, questionnaire or speech examinations.
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