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Study of influence of hydroxyethylcellulose on eye drops weight
Sváčková, Radka ; Šklubalová, Zdeňka (advisor) ; Zatloukal, Zdeněk (referee)
Study of influence of hydroxyethylcellulose on eye drops weight Radka Sváčková Abstract: The purpose of the work was a study of influence of hydroxyethylcellulose ingredient on weight of eye drops various dripping adapters, made of gum and plastic, in two different angles of dripping of concentration line 0,16 - 0,75 % HEC solution with 6 - 98 Pa.s range of viskosity there was found out the weight of the drops and compared to the weight of water drops gained under the same experimental circumstances. In the three - factor screening experiment there was found out that between non-water adapter is no evident diference, both of them during vertical dripping water drops of aproximately same weight (43,5 mg). The weight of drops significantly rised up with HEC ingtedient due to watering of surface of dripping part of both adapters. Watered gum adapter produced significantly larger drops than watered plastic adapter with both kind of dripping angles. The weight of drops significantly went down for both studied adapter with reducing the dripping angle from 90ř to 45ř. There was found out in this detail study quite large rising of the eye - drop weight with present of HEC ingredient of concentration range 0,16 - 0,75 % in comparison to the weight of water drops for both dripping adapter. The largest drops with...
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Development and analysis of online news on the Czech market
Hlaváčková, Ivana ; Ševčík, Miroslav (advisor) ; Arltová, Markéta (referee)
A traditional printed newspaper is being replaced by an online one. This is one of the reasons why I in this thesis focus just on internet journalism. The online journalism servers I present in a relation to other periodicals -- newspapers, broadcast and television. The thesis describes and analyses main development trends in the Czech media market. It puts an emphasis on economic sections of general news and it also compares these sections with specialized economic servers. An important part of the thesis is focused on an analysis of reader's attendance which results in a rank of the most popular news servers. The model of the time series analysis is set up for two websites and it predicts future development trend in the number of real users of online news. The aim of this thesis is to provide a general view on the contemporary situation and also to describe the developmental tendency of online reporting. The result of the dissertation is the prediction of future development trend of online reporting servers.
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Specifics of business negotiations with German partners
Homzová, Zuzana ; Král, Petr (advisor) ; Vokáč, Matěj (referee)
The main task of the thesis is to characterize the German business practices, which are influenced mainly by cultural characteristics and standards. This work take stand for empirical research based on the experience of Czech companies with German partners. The main objective is to find out, whether the theory is in line with the practice of Czech companies. In the first part of my paper I write about local characteristic of the Federal Republic of Germany. The second chapter characterizes tendencies in behavior of the German and Czech business partners. I analyze differences between Czech and German cultural standards in international trade relations. The third chapter is about process and forms of business negotiations with Germans. In the last part of my work I mention my personal knowledge learned from personal interviews, conducted with representatives of Czech companies trading in the German market and also from my questionary research.
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Correlation between Wingate anaerobic test (WAT30) and on-ice field MM636 test
Wolf, Tomáš ; Dovalil, Josef (referee) ; Heller, Jan (advisor)
3 Abstract: The purpose of this study was to compare classic Wingate anaerobic test with on-ice specific field test MM636 and also evaluate reliability and validity of MM636. The MM636 uses an on-ice continuous skating protocol to induce a physical stress on a participant`s anaerobic energy system. Subject is instructed to skate at maximal speed back and forth 6 times 36m distance (blue base lines) with full equipment and stick. 22 elite junior ice hockey player age between 16-20 years perform both tests with one week rest pause between them. The maximal anaerobic power (Pmax) significantly (p<0,025) correlated (r = -0,45), while for anaerobic capacity (AnC) we found only non- significantly (p>0,1) correlation (r = 0,28) with Wingate anaerobic test. The blood lactate levels were very similar after MM636 and WAT30. The measured difference was only 0,5 mmol/l. The Reliability of MM636 during a retest were significant (p<0,001) for both AnC (r = 0,97) and Pmax ( r = 0,73). The MM636 appeared to be valid and reliable test, but only a poor correlation was observed between WAT30 and MM636 in this group of hockey players. Title: Correlation between Wingate anaerobic test (WAT30) and on-ice field MM636 test. Objective: Estimating validity and reliability of MM636 and measuring correlation between WAT30 and MM636....
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Sun for human being
Mikysková, Milena ; Skarlantová, Jana (advisor) ; Hazuková, Helena (referee)
The work describes art project preparation and its carrying out two methodic lines. The first one is devoted to colours and its aim is playing with colours and develoment of colour perceiving abilities. In the other methodology line connection between different school subjects is examined, relationships between literature, drama and art. The line content is based on the mystic legend about Daidalos and Ikaros.
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Novel approaches for development of in vitro liver cell models
Smutný, Tomáš ; Pávek, Petr (advisor) ; Mičuda, Stanislav (referee) ; Kollár, Peter (referee)
1 Abstract Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Tomáš Smutný, MSc. Supervisor: Prof. PharmDr. Petr Pávek, Ph.D. Title of doctoral thesis: Novel approaches for development of in vitro liver cell models. The liver is a main metabolizing organ in the body. Therefore, the evaluation of hepatic metabolism is a crucial step during drug development. Moreover, a liver damage induced by drugs is another task to be assessed in drug development. In vitro liver cell models allow addressing some of these concerns. Up to date, primary human hepatocytes are considered as a "gold" standard of in vitro liver cell models. Additionally, other liver model systems are used such as liver tissue slices, subcellular fractions, liver cancer cell lines and hepatocytes derived from stem cells. Despite the significant progress towards right estimation of pharmacokinetic and toxicological parameters of drug candidates during drug development, current in vitro systems still suffer from various drawbacks. One of these limitations is their insufficient similarity with in vivo-like phenotype associated with low metabolic capacity of the models. In last several years, we were victims of tremendous effort to improve existing models such as 3D models, co-culture and...
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Speech Instruction and the Prevention of Break-downs in Communication Abilities in a Nursery School
Kramosilová, Zuzana ; Šumníková, Pavlína (referee) ; Květoňová, Lea (advisor)
The Graduation paper is directed at the validation of touch capabilities of visually impaired children of the age 13-17 years, through application of STIP test. STIP, developed in United Kingdom, is transformed into doted Braill code and verifies the speed of reading the numbers. Accuracy vs. error rate in the lines, speed of reading and concentration (attention) will be assessed. On the basis of the test evaluation aligned with relevant manual, the performance of children is compared with the UK children in the same age category. Following the comparison, the overall evaluation of this research is performed.
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Marketing support of the Baby Well product
Zahradníková, Adéla ; Halík, Jaroslav (advisor)
This bachelor thesis examines a form of marketing communication, which is referred to as bellow-the-line (BTL). It's arranged chronologically according to the individual steps, which were taken in the course of the project. It observes the environment of an advertisement agency, which has the task of implementing a sales promotion for PG Corporation. This is client who functions in the children segment of the market with their brand Baby Well. Thus in the first part is a brief introduction of the PPD Services s.r.o. agency, which was responsible for the execution of the whole project. In the next part is described the analysis of the sales promotion. At first the assignment of the client is analyzed -- the so-called brief -- and its essentials. After that attention is turned to the production of a tour plan, composition of a budget and to a very important training of the hostess, with the client presence. In this part is described in detail the task of the hostesses and their equipment for the given promo action. In the conclusion of this thesis its' given goal is answered, which is to see if from an investment point of view it pays off for the client to continue this form of marketing communication with the client and if it's sensible to continue. Information for the whole bachelor thesis has been for the most part gathered from own experience and the documentations of the PPD Services s.r.o. advertisement agency. The author's consciousness about the given topic has also been raised by books, which are mentioned as sources of this bachelor thesis.
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Viscoelastic properties of microcrystalline cellulose of Avicel PH 200
Skálová, Marie ; Řehula, Milan (advisor) ; Špaček, Vladimír (referee)
In this dissertation the viscoelasticity of the most common excipient microcrystaline celulose was valuated and viscoelasticite parametres were compared to three substances. Viscoelasticity was valuated by two methods..The first method is Creep test. In this analyze the compression force is constant and hold for 180s. During this time height of the tablet was lowered. The diffrences of tablet height was noted and used for calculation in Crčel test. Parameters of elasticity got by this method are FCT1,FCT2 and parameters of plasticity are PCT1,FP. When the parameters of elasticity increase the elasticity decrease. When the parameter FP increases the plasticity increases too. The higher the value of PCT1 is the lower is the plasticity. Stress relaxation is the second method. In this analyze hight of tablet is constant and decline compression force is recorded. In this analyze we noted the decline for 180 sec. In this way we get parameters of elasticity ESR1, ESR2, ESR3 and parameters of plasticity PSR1, PSR2, PSR3. The plasticity increases when parameter P increases. Comparing three substances the elasticity increases in-line Emcompress, Avicel, Flowlac and the elasticity decreases in-line Emcompress, Avicel, Flowlac.
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Consumer protection in on-line shopping
Kristejnová, Veronika ; Kořánová, Helena (advisor) ; Hůlová, Marie (referee)
The aim of this task is an assignment of seller duties according to legislation. These duties should be followed not only in a process of purchase, but even in an after-shopping phase. I also dealt with a carrying out of supervision and with an existence of consumer associations. A fulfillment of checklist was also a part of this task. The goal of this was revealing of the experience with e-shop purchases.
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