National Repository of Grey Literature 232 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Evaluation of the lubrication effect of mesoporous silicates
Borůvková, Gabriela ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Sebastien Bailey Student: Gabriela Borůvková Title of Thesis: Evaluation of the lubrication effect of mesoporous silicates The tablet production requires facilitation of ejection of tablet out of die for which are used excipients called lubricants. This thesis evaluates the lubrication effect of mesoporous silicates Neusilin US2 (NUS) and Aeroperl (AE) in concentration 0.5 and 5 %. The model tableting mixture composed of microcrystalline cellulose and lactose monohydrate in a ratio of 1:1 was prepared in a Turbula mixer. The mixtures containing NUS or AE, respectively, were prepared, alternatively in the combination with addition of 1 % magnesium stearate. By the evaluation of bulk density, tapped density, Hausner ratio, and consolidation dynamics, the flow properties of mixtures were tested. Afterwards, 30 tablets were compressed from the mixtures, and the compression process and ejection force were evaluated. Then, the compressed tablets were evaluated for friability, tensile strength, and the disintegration time. The results were compared with the tableting mixtures containing a high concentration of a pharmaceutical active substance....
Study of tableting materials and tablets from co-processed dry binder based on mannitol and microcrystalline cellulose.
Vnučáková, Iveta ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Student: Iveta Vnučáková Title of Thesis: Study of tableting materials and tablets from co-processed dry binder based on mannitol and microcrystalline cellulose. This thesis deals with the study of tableting materials and orally dispersible tablets containing co-processed dry binder F-melt® type M with the drugs domperidone and ibuprofen. All formulations also include the sweetener sucralose in a concentration of 1 %. For placebo tablets and directly pressed tablets, lubricant is added in a concentration of 1%, for granules the lubricant is in a concentration of 1.5%. Domperidone formulations contain magnesium stearate and the tablets are compressed at the compression force of 3 kN and ibuprofen formulations compressed at a compression force of 5 kN contain sodium stearyl fumarate. The flow properties of tablets, the energy profile of compression process, tensile strength, friability, porosity, disintegration time, as well as the time of wetting and water absorption are evaluated. Placebo tablets showed the highest total compression energy (Emax). Due to the influence of drugs and granulation, Emax decreased. The highest tablet tensile strength was...
The effect of solvent on disintegration time of liquisolid systems in the form of capsules
Helerová, Ladislava ; Vraníková, Barbora (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr. Barbora Vraníková, Ph.D. Consultant: MSc. Andreas Niederquell Student: Ladislava Helerová Title of Thesis: The effect of solvent on disintegration time of liquisolid systems in the form of capsules According to the literature, the resulting liquisolid (LS) powders may be formulated into the form of tablets, pellets or hard gelatine capsules. However, the available resources about liquisolid systems do not consider possible interactions between the used excipients and capsule shell. Carriers can adsorb the water from the gelatine capsule and hence cause its brittleness, while the solvent can penetrate the capsule shell and thereby affects its integrity and properties. For these reasons, LS capsules containing mixtures of the carrier Neusilin® US2 (NUS2) with different amounts of propylene glycol (PG), polysorbate 80 (PS 80) or the cyclosporine A (CysA) dispersions in these solvents were prepared and tested. The disintegration time in three dissolution media, differential scanning calorimetry (DSC) and infrared spectroscopy (IR) were evaluated to study the changes in the capsule properties. The obtained results showed that the disintegration time of LS capsules was prolonged...
Adhesive properties of thin layers based on plasticized polyesters
Soukupová, Jana ; Šnejdrová, Eva (advisor) ; Šklubalová, Zdeňka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Name: Jana Soukupova Title of diploma thesis: Adhesive properties of thin layers based on plasticized polyesters Supervisor: PharmDr. Eva Snejdrova, Ph.D. This diploma thesis deals with rheological, adhesive and dissolution properties of thin layers based on the branched polyester of D,L- lactic acid and glycolic acid, plasticized with methyl- salicylate, and loaded with salicylic acid. The theoretical section describes bioadhesion, its mechanism and theories, in vitro adhesive tests focused mainly on the method of rheological synergism, tensile and "wash off" tests. In the experimental section, the flow properties of plasticized polyesters, hydrated mucin from porcin stomach, and their mixtures were studied using absolute rotational rheometer. The analysis of the viscosity curves revealed that plasticized polyesters are Newtonian systems, mucin and its mixtures with polymer have pseudoplastic behaviour. Adhesive properties of the thin layers were established by equation of rheological synergism based on viscosity of polymer, mucin and their mixtures measured at shear rate of 10 s-1 . The adhesive properties of thin layers were also determined using tensile test on rheometer, and evaluated as the...
Evaluation of compressibility of granular powders and tableting mixtures with the high content of active substance.
Paris, Tereza ; Svačinová, Petra (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department od: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Tereza Paris Title of Thesis: Evaluation of compressibility of granular powders and tableting mixtures with the high content of active substance This thesis deals with the evaluation of compressibility of granular powder and tableting mixtures with high drug content. Eleven batches of tablet formulations with different type of filler - microcrystalline cellulose or lactose and different type of extragranular disintegrants - sodium croscarmellose or crospovidone in concentrations of 2 %, 3,7 % or 5,4 % and two granular powders with only different type of filler were prepared by two methods. The first method was used to prepare tablets with the same height and the second method to prepare tablets with the same porosity as the oval tablets made from identical tableting mixtures. The compressibility was evaluated using the force-displacement method parameters and volumetric elastic recovery. Another tested parameter was tensile strength and, for one group of tablets, also porosity. The obtained results show that both, the type of filler and the type of extragranular disintegrant, had an effect on the force-displacement method parameters especially at...
The use of Turbula® mixer in homogenization of a mixture of drug with the AmylFarm® filler for the preparation of oral powders in Pharmacy
Kadlecová, Romana ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: PharmDr. Sylva Klovrzová, Ph.D. Student: Mgr. Romana Kadlecová Title od Thesis: The use of Turbula® mixer in homogenization of a mixture of drug with the AmylFarm® filler for the preparation of oral powders in Pharmacy In this experimental work, the influence of container loading and homogenization time on the content uniformity of divided oral powders mixed in a Turbula T2F mixer was investigated. The speed of mixer 49 rpm was constant. The powder mixtures containing 20 mg of the active substance propranolol-hydrochloride in the AmylFarm filler were prepared in three volumes 37 ml, 74 ml and 111 ml, corresponding to the 100, 200 and 300 capsules, respectively. The results were compared with the conventional mixing using a mortar and pestle. The insignificant difference in homogeneity of mixtures prepared by both methods was proved. The optimum mixing time in a rotary mixer was 10 minutes for a 37 ml mixture, and 15 minutes for the larger mixture volumes 74 and 111 ml.
The influence of micronized poloxamer on the flow and compaction of a model tableting mixture
Dunlap, Brooke Alexandra ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. Zdenka Šklubalová, Ph.D. Consultant: Sebastien Bailey Student: Brooke Alexandra Dunlap Title of Thesis: The influence of micronized poloxamer on the flow and compaction of a model tableting mixture Lubricants are an important excipient used in the production of tablets, they facilitate powder flow during manipulation, prevent powder sticking to the press during compression, and aid in tablet ejection. In this thesis the effect of four different concentrations 0.5, 1.0, 1.5, and 2.0 % w/w of micronized Poloxamer 188 on a model tableting mixture consisting of a 1:1 ratio of Microcrystalline Cellulose (MCC) and Lactose (L) was tested to determine its effectiveness as a lubricant for tablet manufacturing. Flow through an orifice, angle of repose, Hausner ratio, compressibility index, dynamics of consolidation, and powder bed porosity were tested. There was no increase in flowability of the powder at any concentration of P188 in any test used, all mixtures showed poor or very poor flow behaviour. Compression process was evaluated according to the force displacement method at three different compression forces (5 kN, 7 kN, 10 kN) and special attention was paid to ejection force. P188 is an...
The influence of micronized poloxamer on the flow and compaction of a model tableting mixture
Dunlap, Brooke Alexandra ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. Zdenka Šklubalová, Ph.D. Consultant: Sebastien Bailey Student: Brooke Alexandra Dunlap Title of Thesis: The influence of micronized poloxamer on the flow and compaction of a model tableting mixture Lubricants are an important excipient used in the production of tablets, they facilitate powder flow during manipulation, prevent powder sticking to the press during compression, and aid in tablet ejection. In this thesis the effect of four different concentrations 0.5, 1.0, 1.5, and 2.0 % w/w of micronized Poloxamer 188 on a model tableting mixture consisting of a 1:1 ratio of Microcrystalline Cellulose (MCC) and Lactose (L) was tested to determine its effectiveness as a lubricant for tablet manufacturing. Flow through an orifice, angle of repose, Hausner ratio, compressibility index, dynamics of consolidation, and powder bed porosity were tested. There was no increase in flowability of the powder at any concentration of P188 in any test used, all mixtures showed poor or very poor flow behaviour. Compression process was evaluated according to the force displacement method at three different compression forces (5 kN, 7 kN, 10 kN) and special attention was paid to ejection force. P188 is an...
Study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with antihypertensives.
Martiníková, Lenka ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Student: Lenka Martiníková Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with antihypertensives. This thesis deals with the study of tableting materials and orally dispersible tablets containing coprocessed dry binders Ludiflash® , Prosolv® ODT G2 and Parteck® ODT in combination with the antihypertensives ramipril and perindopril. The tablets also contained the sweetener sucralose and the lubricant magnesium stearate in a concentration of 1%. The tablets were compressed at a compression force of 3 kN. The evaluated parameters were the energy profile of the compression process, tablet tensile strength, friability, disintegration time, wetting time, water absorption and tablet porosity. The highest values of the total compression energy showed tablets containing Ludiflash® in combination with perindopril and the lowest values had tablets containing Prosolv® ODT G2 with ramipril. Tablets from the combination of Parteck® ODT with ramipril and Ludiflash® with perindopril showed the highest tensile strength of the tablets. Conversely, tablets from Prosolv® ODT G2 with both drugs...
The effect of solvent on disintegration time of liquisolid systems in the form of capsules
Helerová, Ladislava ; Vraníková, Barbora (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr. Barbora Vraníková, Ph.D. Consultant: MSc. Andreas Niederquell Student: Ladislava Helerová Title of Thesis: The effect of solvent on disintegration time of liquisolid systems in the form of capsules According to the literature, the resulting liquisolid (LS) powders may be formulated into the form of tablets, pellets or hard gelatine capsules. However, the available resources about liquisolid systems do not consider possible interactions between the used excipients and capsule shell. Carriers can adsorb the water from the gelatine capsule and hence cause its brittleness, while the solvent can penetrate the capsule shell and thereby affects its integrity and properties. For these reasons, LS capsules containing mixtures of the carrier Neusilin® US2 (NUS2) with different amounts of propylene glycol (PG), polysorbate 80 (PS 80) or the cyclosporine A (CysA) dispersions in these solvents were prepared and tested. The disintegration time in three dissolution media, differential scanning calorimetry (DSC) and infrared spectroscopy (IR) were evaluated to study the changes in the capsule properties. The obtained results showed that the disintegration time of LS capsules was prolonged...

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