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Immunoprotective character of polymer cytotoxic drugs
Šírová, Milada ; Říhová, Blanka (advisor) ; Turánek, Jaroslav (referee) ; Rabišková, Miloslava (referee)
18 I. INTRODUCTION Cancer is a serious health problem worldwide. In economically developed countries, it is a second most frequent cause of death after cardiovascular dis- eases, and the number of oncological patients continuously increases with the increasing age of population. The mainstay of cancer therapy is combination of surgery, radiation and chemotherapy. Whilst surgery and radiation are relatively precise and suitable to achieve a local control over the tumor, chemotherapy exerts a systemic ef- fect. These three modalities, when properly combined and sequenced, can cure a substantial number of hematological cancers and a smaller, but still significant subset of various solid tumors. Most cytostatic/cytotoxic drugs that are now in common use target the cells with high proliferation rate. The non-selective character of chemotherapy leads to increased toxicities towards normal rapidly proliferating cells. This means that the drugs have to be used at suboptimal doses, leading to development of (multi)drug resistance, metastatic disease and, eventually, to failure of the therapy. Innovative therapeutic strategies need to be developed in order to achieve better treatment outcome. For that purpose, several approaches are be- ing applied. First, sophisticated genomic and proteomic research could identify...
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Analysis of the position and operations of the International monetary fund in the global economy
Hromádka, Jan ; Žamberský, Pavel (advisor)
The thesis analyzes how IMFs operations transformed as the changes took place in the global economy after world war two. Policy and means used by IMF to achieve its purposes are examined focusing on their effectiveness. The analysis illustrates an apparent change in the role the institution is playing in the global economy. In the first three decades after the world war two the IMFs key role was to maintain surveillance over the rules of the monetary system established at international financial conference in Bretton Woods. The introduction of floating exchange rate systems in developed countries, oil crisis and independence of many African countries caused a shift in IMFs main focus towards developing countries, long-term financing and technical assistance. The analysis concludes that the institution was only in part successful in its mission to maintain global economic stability only in part. In the nineties it reacted promptly to financial crisis by introduction of new facilities and by activating in coordination with other global players of large financial support for the affected countries. However in the period before the financial crisis occurred more attention IMF should have given more attention to precautionary measures eliminating the risks associated with capital volatility.
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The impact of nex luxury cars on road traffic fatalities and serious injuries in the Czech Republic
Zapletal, Jan ; Houdek, Petr (advisor) ; Rod, Aleš (referee)
This paper analyzes the negative effect of new luxury cars on road traffic fatalities and serious injuries in the Czech Republic. The analysis has been done using linear regression method on time series dataset for years 1991-2010. The results may show (with low significance) that 1 % increase in share of luxury cars on total number of registered vehicles results in 0.39% decrease of road traffic deaths accidents and 0.03% decrease in number of seriously injured persons. Results, which are contradictory to other previous studies, were probably caused by the broader definition of luxury cars, including new classes which weren't included in earlier papers. The results may show as well that new luxury cars don't increase significantly the risk of death for car passengers in other vehicles, what may have been due to prevailing share of low risk luxury cars in traffic than the higher risk ones. Very surprising finding is that with increasing alcohol consumption there would be less people seriously injured. The increase in alcohol consumption by 1 % would decrease the number of seriously injured people by 2.36 %. It is probably caused by the responsibility of the people who in threat of the punishment didn't drive a car after they have consumed alcohol. The impact of demerit point system may show, that its introduction decrease accidents fatality rates by 2.31 %.
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The Application of Technical Analysis to the Czech Capital Market in the Period of Economic Recession
Špringer, Milan ; Pígl, Jan (advisor)
These lines deal with both theoretical and analytical view of real usability of individual methods and techniques in the Czech capital market in the period of economic crisis (2008-2009). The document introduces the basic technical analysis methodology (the technique based on graphics outputs of specific data files and the technique based on the mathematical indicators) in the theoretical chapters. An introduction and subsequent description of the mentioned methodology in the sphere of price predication of shares and funds is the main tendency in this theoretical chapter, not the profound interpretation. The work attends to concrete analysing of some basic hypothesises of common usability of our main theme, technical analysis. Price development of the selected titles and the endeavour to apply the techniques described in the theoretical chapter to these data series are included in the analytical chapter. The reader wants to make his own idea of how is the real usage of such an analysis difficult. Very helpful is also a demonstration of a big measure of subjective level in production and calculation of some indicators. Final part shows us the most interesting results for the practical usability of the mentioned methods and indicators in the sphere of the Czech Capital Market.
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Registered partnership and its potential property consequences
Kutálek, Karel ; Frintová, Dita (referee) ; Hendrychová, Michaela (advisor)
59 Summary Registered Partnership and Its Potential Property Consequences I have chosen this particular topic for my thesis because according to my opinion the institute of registered partnership is still quite new and unknown to many people in the Czech Republic and the Czech legal theory concerning this topic is not much rich so far. The aim of my thesis is to look at the issue of registered partnership more deeply, not only from the position of the questions of from where, how and why registered partnership actually came to the Czech Republic. This analysis focuses on the legal consequences of registration for partners and among themselves, especially in comparison with the two main variants of cohabitation - marriage and unmarried cohabitation. To this end, the work is divided into three main chapters, which are further subdivided into subchapters and these are eventually further subdivided into smaller parts. The thesis begins with the Introduction where the intended aims and goals of this work are described. Followed by the First Chapter which presents the topic of the work by its basic question "What the homosexuality actually is". This chapter discusses the concept of homosexuality and its development, looks closer at the term "coming out" and the number of homosexuals in the society and in the end...
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Aortic stenosis
Šmíd, Michal ; Rokyta, Richard (advisor) ; Rosolová, Hana (referee) ; Ošťádal, Petr (referee) ; Sovová, Eliška (referee)
Aortic annulus and ascending aorta: comparison of preoperative and periooperative measurement in patients with aortic stenosis Introduction Precise determination of the aortic annulus size constitutes an integral part of the preoperative evaluation prior to aortic valve replacement. It enables the estimation of the size of prosthesis to be implanted. Knowledge of the size of the ascending aorta is required in the preoperative analysis and monitoring of its dilation enables the precise timing of the operation. Our goal was to compare the precision of measurement of the aortic annulus and ascending aorta using magnetic resonance (MR), multidetector-row computed tomography (MDCT), transthoracic echocardiography (TTE), and transoesophageal echocardiography (TEE) in patients with degenerative aortic stenosis. Materials and Methods 15 patients (9 males and 6 females, mean age 68.8 + 7,1 years,) indicated for aortic valve replacement due to degenerative aortic stenosis were enrolled into this prospective study. The study followed the principles established in the Declaration of Helsinki. The protocol was accepted by the local ethical board and informed consent was obtained from each patient. The study was performed in a tertiary medical centre. Preoperatively, TTE was performed in all patients, while TEE was...
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Czech insurance market in terms of implementing Solvency II methodology
Sirotková, Blanka ; Ducháčková, Eva (advisor) ; Daňhel, Jaroslav (referee)
My bachelor thesis deals with the current situation on the Czech insurance market in connection with the introduction of Solvency II. Solvency II will have an effect in the near future on its appearance. In the first part of my thesis I dismantled the structure of the insurance market in terms of structure and ownership of insurance companies, the risks affecting the business of insurance and the insurance market indicators, among which is one solvency (Solvency I). The second part describes the Solvency II and to compare it with the current solvency rules and Basel II. At the end of my work I have indicated the likely impact of the new methodology on the Czech insurance market.
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Foreign Policy after Liberation in 1945. (16. 5. - 31. 12. 1945)
Němeček, Jan ; Kuklík, J. ; Jedličková, Blanka ; Němečková, D.
First volume of new, third series of the project on Documents on Czechoslovak Foreign Policy contains documents from May to December 1945. The documents concentrate mainly the restoration of postwar-Czechoslovakia, Czechoslovak-Soviet relations (mainly cession of Subcarpathian Ruthenia), Czechoslovak-Polish conflict on Teschen, relief of UNRRA and another question. Documents are published including historical and editorial introduction, list of documents, English summaries of documents and name index.
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Introduction to Freestyle Snowboarding
Suchanová, Klára ; Vomáčko, Ladislav (advisor) ; Matošková, Petra (referee)
Název práce: Úvod do freestyle snowboardingu Introduction to ťreestyle snowboarding Cíle práce: Sestavení metodické řady pro výuku ťreestyle snowboardingu. Výklad širších souvislostí freestyle snowboardingu. Metoda: Metodická řada freestyle snowboardingu byla vytvořena na základě analýzy textů a dokumentů a empirického pozorování v dané oblasti. Výsledky: Metodická řada freestyle snowboardingu. Pojednání o záležitostech freestyle snowboardingu. Klíčová slova: freestyle snowboarding, metodická řada, rozhodování ve snowboardingu, snowboardové organizace, teorie triků.
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Examining the significance of peptides regulating the intake of food and the nutritional state of children and adolescents
Bronský, Jiří ; Průša, Richard (advisor) ; Pelouch, Václav (referee) ; Hyánek, Josef (referee)
Introduction: Regulation of food intake and nutritional status is mediated by complex interactions of regulatory peptides of the central nervous system, gastrointestinal tract and adipose tissue. These systems are connected by feedback loops which inform the centre about amount of ingested food and energy reserves in the organism. Dysfunction of any of these regulatory areas may lead to changes in nutritional status of the organism. Methods: We used radioimmunoassay to measure plasma levels of orexin A, total ghrelin and serum levels of leptin and enzyme immunoassay to measure serum levels of adiponectin in healthy subjects and in children with obesity, anorexia nervosa, Crohn's disease and celiac disease and we evaluated the influence of nutritional therapy on these levels. Moreover, we evaluated relationship of these regulatory peptides to other biochemical and anthropometrical factors of nutritional status. We also measured plasma levels of total and unreduced amylin by enzyme immunoassay with immunofluorescence detection in adult patients with osteoporosis, type II diabetes mellitus and in the control group. Results: During reduction of body weight in obese children and adolescents, there were statistically significant changes of plasma orexin A levels and total ghrelin levels, but we haven't seen any...
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